Ask about this productRelated genes to: TEX14 antibody
- Gene:
- TEX14 NIH gene
- Name:
- testis expressed 14, intercellular bridge forming factor
- Previous symbol:
- -
- Synonyms:
- CT113
- Chromosome:
- 17q22
- Locus Type:
- gene with protein product
- Date approved:
- 2000-06-16
- Date modifiied:
- 2016-05-06
Related products to: TEX14 antibody
Related articles to: TEX14 antibody
- Non-obstructive azoospermia (NOA) is a major cause of male infertility, frequently associated with congenital factors. Nevertheless, the genetic underpinnings of NOA remain largely unclear. - Source: PubMed
Publication date: 2026/01/28
Xu JianzeLi TongtongHu YuweiLi MengjingHu JianlinCai YulingZhang MingyuLu GangChan Wai-YeeChen Zi-JiangLiu HongbinChen Xiang-Feng - The long-term immunological effects of prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in people living with Human Immunodeficiency Virus (HIV) remain poorly understood. This study aimed to characterize plasma proteomic alterations associated with previous SARS-CoV-2 infection in HIV-infected individuals and to identify potential biomarkers and affected pathways. High-throughput liquid chromatography–tandem mass spectrometry (LC–MS/MS) was performed on plasma obtained from three groups: HIV-infected individuals with documented prior SARS-CoV-2 infection, HIV-monoinfected individuals, and healthy controls. A total of 13,675 proteins were identified. Hierarchical clustering and sparse partial least squares discriminant analysis revealed distinct proteomic profiles in the prior-SARS-CoV-2 group. Ten proteins with the highest discriminatory power—PRR11, TEX14, METTL9, NMD3, PXT1, CRISP2, MELK, SPF27, GCP6, and GTPBP8—were associated with cell cycle regulation, RNA processing, apoptosis, mitochondrial function, and cytoskeletal organization. Subcellular localization indicated predominant nuclear and cytoplasmic involvement, suggesting alterations in transcriptional regulation and intracellular structural dynamics. These signatures imply that preceding SARS-CoV-2 exposure may compound HIV-associated immune dysregulation and disrupt cellular homeostasis. The findings offer novel molecular insights into the persistent biological impact of SARS-CoV-2 in the context of HIV and identify candidate proteomic biomarkers with potential utility for risk stratification and targeted intervention in immunocompromised populations. - Source: PubMed
Publication date: 2025/12/09
Chanthara ChayaninKhattiya JanyaRoytrakul SittirukAkekawatchai ChareepornPhaonakrop NarumonNiyomdecha Nattamon - TEX14 is essential for the formation and maintenance of the intercellular bridge (ICB) which is one of the major cellular junctions required for spermatogenesis. Previously, TEX14 was shown to block germ cell abscission prior to cytokinesis through the GPPX3Y (Gly-Pro-Pro-X-X-X-Tyr) motif. Although TEX14 could have the potential to inhibit cell proliferation, it is difficult for full-length TEX14 to be applied as anti-tumour agents because of its molecular size. In addition, the involvement of amino acids surrounding the GPPX3Y motif in the ICB formation as well as cell proliferation remains to be investigated for anti-tumour treatment. In this study, we show that partial peptides of TEX14, which include the GPPX3Y motif, are sufficient to inhibit the proliferation of a variety of cancer cells and efficiently induce apoptosis. In addition, the length and variation of amino acids surrounding the GPPX3Y motif might attenuate the efficiency of partial TEX14 peptides to inhibit cell proliferation as well as to induce apoptosis. Thus, our findings suggest that these TEX14 short peptides could be useful to suppress cell division in continuously proliferating cells such as cancer cells without affecting germ cell differentiation and have the potential as anti-tumour agents. - Source: PubMed
Publication date: 2025/11/11
Iwamori TokukoSakurai YusukeSultana TasrinKatakura YoshinoriIwamori Naoki - SNARE proteins are required for membrane fusion events throughout the endomembrane system, and are therefore associated with vesicular transport. Here, we found that the SNARE family member, YKT6, is indispensable for male fertility in mice. Conditional Ykt6 knockout in pre-meiotic and meiotic germ cells leads to complete sterility and meiotic arrest in male mice, which exhibit loss of spermatocytes in seminiferous tubules, but without obvious disruption of chromosomal behaviours during meiosis. We observed that the abundance of syncytia increases along with abnormal morphology of the Golgi apparatus, while lysosomes decrease in Ykt6-cKO testes. Quantitative proteomics and immunofluorescent staining both showed dysregulation of vesicular transport in YKT6-deficient spermatocytes. Additionally, the recombinant mouse proteins, HA::YKT6 and MYC::STX1A, could interact in vitro, further supporting a likely role in mediating transport vesicle fusion with the plasma membrane. Finally, the absence of TEX14 signal within syncytia and enlarged TEX14 rings between spermatocytes together suggest a failure to stabilise intercellular bridges in Ykt6-cKO testes. These results demonstrate that YKT6 is required for male fertility by promoting meiosis progression through vesicular transport regulation during spermatogenesis in mice, expanding our understanding of YKT6 functions, and suggesting a possible strategy for future interventions for male infertility in humans. - Source: PubMed
Publication date: 2025/06/18
Cen JieYu XiaochenWang ZiqiLiu WenboXu JianzeFang QianGao FeiCao YongzhiLiu Hongbin - Intercellular bridges (ICBs) are critical in intercellular communication, coordinated cellular development, and the equilibration of cytoplasmic contents between germ cells during vertebrate spermatogenesis. Mammalian TEX14 is specifically expressed in the testes and is a pivotal component of ICBs. It is indispensable for proper spermatogenesis; its deficiency causes meiotic arrest at the pachytene stage of meiotic prophase I, resulting in male infertility with non-obstructive azoospermia (NOA) in murine models. However, the specific effects of TEX14 deficiency on spermatogenesis remain poorly understood. In this study, we identified a novel compound heterozygous mutation in TEX14 (c.802A>T, p.S268C and c.1021C>T, p.R341*) in a patient with NOA. Functional analyses demonstrated that these mutations disrupted TEX14 synthesis. This led to spermatogenic failure characterized by meiotic arrest at the pachytene stage and impaired ICB assembly in the testes harboring the mutations. Our findings provide robust evidence that pathogenic biallelic TEX14 mutations are recurrent genetic etiologies of NOA in humans. - Source: PubMed
Publication date: 2025/06/10
Li GuotongZhou ShushuLi YuqianAtta SanaXia XunSha XuanHua RongZhou PingWei ZhaolianCao YunxiaWu Huan