Ask about this productRelated genes to: TJP2 antibody
- Gene:
- TJP2 NIH gene
- Name:
- tight junction protein 2
- Previous symbol:
- DFNA51
- Synonyms:
- ZO-2, X104, ZO2
- Chromosome:
- 9q21.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-01
- Date modifiied:
- 2019-04-23
Related products to: TJP2 antibody
Related articles to: TJP2 antibody
- Late gestation heat stress in dairy cows reduces offspring's capacity to absorb colostrum immunoglobulin G (IgG). This study evaluated small intestine histomorphology, cellular turnover, and gene expression profiles of in utero heat stressed versus in utero cooled heifers at birth. For the last 54 ± 5 d of gestation, pregnant dams were housed in a free stall barn and were either heat stressed (shade of the barn) or cooled (shade, fans, and water soakers) during a subtropical summer. Heat stressed pregnant cows responded physiologically by elevating respiration rate and skin temperature relative to their cooled counterparts (+25 breaths per minute and +1.7°C) and gave birth to heifers who were in utero heat stressed (IUHS) or in utero cooled (IUCL), respectively (n = 8/group). Heifers were euthanized at birth (before colostrum feeding) to harvest gastrointestinal tract (GIT) tissues. Histomorphology (villi length, width, and crypt depth) was assessed from duodenum, jejunum, and ileum tissue portions of the GIT, via H&E staining. Cellular turnover (death/proliferation) was quantified in crypt and villi regions of the jejunum and ileum via immunohistochemistry. The fluorescence intensity of tight junction proteins (occludin and zona occludens-1) and the neonatal Fc receptor were assessed in the jejunum and ileum. Jejunum and ileum tissue samples were snap-frozen for gene expression analysis of endosomal (FCGRT, DAB2, MAMDC4), tight junction (TJP1, TJP2, TJP3, OCLN, CLDN1), heat shock (HSP90AA1, HSF1), and autophagy (ATG3, ATG5) related genes by qPCR. Data were analyzed using PROC MIXED or PROC GLIMMIX. There were no differences in villi length or width across intestinal sections, nor crypt depth in the duodenum and jejunum; however, ileal crypts were shorter in IUHS heifers. No differences between treatments were detected in the rate of proliferation within either tissue section. Apoptosis was increased crypts of the jejunum and villi of the ileum in IUHS heifers, but unchanged in ileal crypts and jejunal villi. Occludin abundance tended to be reduced in the jejunum of IUHS heifers only, whereas other tight junction proteins were largely unchanged. Abundance of the neonatal Fc receptor was decreased in the jejunum of IUHS heifers and not different between treatments in the ileum. Gene expression analysis indicated a tendency for upregulation of CLDN1 and significant downregulation of TJP2 in the jejunum, and a significant upregulation of MAMDC4, ATG5, and HSF1 in the ileum of IUHS heifers. Additionally, expression of tight junction genes OCLN, TJP1, TJP2, and TJP3 were upregulated in the ileum of IUHS heifers. Overall, IUHS had minimal effects on histomorphology but disrupted cellular turnover and tight junction regulation, with reduced neonatal Fc receptor abundance in the jejunum, providing insight to mechanisms that may be responsible for impaired colostrum IgG absorption. These findings suggest that impaired passive immunity in IUHS calves may be attributed to disruptions in intestinal cellular and molecular function rather than gross structural changes. - Source: PubMed
Publication date: 2026/09/17
Guenther Maverick CDavidson Brittney DCangiano Lautaro RSteele Michael ADahl Geoffrey ELaporta Jimena - Hidradenitis suppurativa (HS)-related autoinflammatory syndromes, simply termed as syndromic HS (sHS), represent a group of rare immune-mediated inflammatory disorders in which HS coexists with systemic or cutaneous autoinflammatory features like PASH (pyoderma gangrenosum-PG-, acne and HS), PAPASH (PASH, pyogenic arthritis), PASS (PG, acne, HS, and ankylosing spondylitis), and SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis). In recent years, genetic studies identified several novel pathogenic variants underlying sHS; however, most investigations rely exclusively on affected individuals sequencing and the absence of parental genomic information limits the possibility to determine inheritance patterns. - Source: PubMed
Publication date: 2026/09/08
Moltrasio ChiaraTricarico Paola MNardacchione Elena MMoura RonaldRoncarà SaraSatolli FrancescaManzo Margiotta FlaviaDini ValentinaMarzano Angelo ValerioCrovella Sergio - Progressive Familial Intrahepatic Cholestasis (PFIC) is a rare liver disorder that, although typically present in childhood, can also occur in adulthood. Early diagnosis is crucial for appropriate clinical management, prognostic assessment, and therapeutic decision-making; however, it remains challenging due to phenotypic variability and the frequent identification of genetic variants of uncertain significance (VUS). Advances in next-generation sequencing (NGS) and whole-exome sequencing (WES) have improved the detection of disease-associated variants, revealing that the same genetic variants-often in a heterozygous state-may lead to adult-onset cholestatic disease, with milder or atypical presentations, while still conferring a significant risk of progressive liver injury and related complications. To assess the diagnostic yield and clinical utility of NGS panels and WES in adults with suspected PFIC or unexplained cholestatic liver disease, focusing on variant interpretation, emerging disease-associated genes, and clinical significance of VUS. A literature review was conducted to assess molecular diagnostics in adult cryptogenic cholestasis, with a focus on studies employing targeted NGS panels and WES. Selected studies were examined for diagnostic yield, variant classification, interpretive challenges, including VUS, and integration with clinical data. Data on patient demographics, sequencing techniques, and variant interpretation strategies were extracted to evaluate the current capabilities and limitations of genomic testing. From an initial search of 211 publications, 15 studies met the inclusion criteria, comprising five large adult cohorts and ten single-patient or trio-based reports. Across 72 patients, sequencing technologies identified 75 pathogenic or likely pathogenic variants, predominantly missense mutations, demonstrating high genetic heterogeneity. The most implicated genes included , , , , and , with diagnostic yields ranging from 13.2% in large heterogeneous cohorts to substantially higher rates in carefully selected individual cases. VUS were identified in up to 67% of cases, highlighting the need for multidisciplinary interpretation integrating clinical, biochemical, and genetic data. Emerging evidence also implicated ciliopathy-associated genes such as , , , , and , expanding the genetic spectrum of adult cholestasis. Clinically, presentations ranged from mild biochemical abnormalities to progressive cholestasis, with pruritus being a common feature across studies. Comprehensive genetic testing significantly enhances diagnostic accuracy, informs prognosis, and guides individualized management in adults with cryptogenic cholestasis. Emerging evidence suggests that ciliopathy-associated genes may contribute to the genetic architecture of adult cholestatic disorders, further expanding the spectrum of disease-associated genes. However, the high prevalence of VUS remains a major challenge, highlighting the need for functional studies, longitudinal follow-up, and improved variant interpretation frameworks. As genomic technologies and analytical approaches continue to evolve, genetic testing is expected to play an increasingly central role in precision hepatology. - Source: PubMed
Publication date: 2026/07/25
Conti AmaliaGabrielli FilippoFerrari SimonaVaisfeld AlessandroDe Masi ClaudiaAzzaroli FrancescoPiscaglia FabioVitale Giovanni - Acute myeloid leukemia (AML) exhibits substantial biological heterogeneity that is not fully captured by current prognostic systems. We aimed to identify transcriptome-wide gene expression markers associated with overall survival in newly diagnosed AML patients. - Source: PubMed
Publication date: 2026/08/08
Tungjitviboonkun SongpholMullapudi NikhilGardev Elly - The late laying period is often accompanied by declines in productive performance, egg quality, and intestinal health in hens. This study used a 2 × 2 factorial design to evaluate the effects of dietary theabrownins (TB), bioactive polyphenols derived from dark tea, on production performance, egg quality, intestinal health, and cecal microbiota in 47- and 67-week-old laying hens. A total of 192 Lohmann Gray hens were fed diets containing 0 or 100 mg/kg TB for 12 weeks. - Source: PubMed
Publication date: 2026/08/10
Zhang LiXu WenwenZhang KeyingDing XuemeiZeng QiufengBai ShipingLiu JingboWang Jianping