Ask about this productRelated genes to: TCL1A antibody
- Gene:
- TCL1A NIH gene
- Name:
- T cell leukemia/lymphoma 1A
- Previous symbol:
- -
- Synonyms:
- TCL1
- Chromosome:
- 14q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-03
- Date modifiied:
- 2017-12-06
Related products to: TCL1A antibody
Related articles to: TCL1A antibody
- Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with complex genetic underpinnings. Understanding the causal relationships between genetic factors and AML risk is crucial for developing targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/05/30
Xia TianWen RuitingWu GuocaiHong YunguangLuo Dasi - The crotonylation reader DPF2 has been implicated in tumor progression, but its role in colon adenocarcinoma (COAD), especially in cell-type-specific immune regulation and metabolic reprogramming, remains unclear. - Source: PubMed
Publication date: 2026/05/18
Wang JingzhiZhou JingyiLiu Lin - Accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy is among the strongest signatures of ageing. Here we investigated the underlying mechanism by calling mtDNA sequence, mtDNA abundance and mtDNA heteroplasmic variants in human blood using whole-genome sequences from approximately 750,000 individuals. We observed that mtDNA single-nucleotide variants (mtSNVs) accumulate sharply at age 60 years, occur at low levels of heteroplasmy, exhibit little evidence of positive selection and are likely to be predominantly neutral. The mutational spectrum of mtSNVs does not reflect oxidative lesions, as is commonly invoked, but is more consistent with mtDNA replication errors. To understand why mtSNVs become detectable with age, we performed a genome-wide association study for heteroplasmic mtSNV burden, identifying germline variants near TERT, TCL1A and SMC4, all of which have been linked to clonal haematopoiesis (CH). Rare-variant analysis also showed that high mtSNV burden is associated with mutations in numerous CH driver genes. These genetic associations persisted even after exclusion of individuals with known CH driver mutations. Our results support a model in which 'cryptic' mtDNA mutations initially arise randomly as replication errors but are undetectable in bulk. They then become apparent only through age-related expansion of cellular clones in blood. We propose that the high copy number and mutation rate of mtDNA make it a sensitive blood-based marker of somatic mosaicism due to CH. Our work mechanistically unifies three prominent signatures of ageing: common germline variants in TERT, CH and observed accrual of mtDNA mutations. - Source: PubMed
Publication date: 2026/05/27
Gupta RahulDurham Timothy JChau GrantKanai MasahiroUddin Md MesbahLu WenhanArgentieri M AustinKarczewski Konrad JHowrigan DanielNatarajan PradeepZhou WeiNeale Benjamin MMootha Vamsi K - Can single-cell, mass spectrometry-based proteomics identify proteins associated with reduced developmental competence of Patl2-/- Metaphase II (MII) mouse oocytes and reveal therapeutic targets for Patl2-related infertility? - Source: PubMed
Publication date: 2026/05/01
Cardona Barberán AAraftpoor EChristodoulaki AFakhar-I-Adil MGoethals JRybouchkin AArnoult CBoel ABühler MPavani K CStoop DGevaert KVanden Meerschaut FHeindryckx B - Aromatase Inhibitors Associated Musculoskeletal Symptoms (AIMSS) are common side effects among hormone receptor-positive breast cancer patients, significantly affecting patients' treatment adherence and quality of life. The individual genetic susceptibility mechanism underlying AIMSS was not well understood yet. This study aimed to validate the association between genetic polymorphisms and AIMSS among Chinese breast cancer patients. - Source: PubMed
Publication date: 2026/03/18
Jing FengJiang LingyunCao YulingTian MaotingQiu JiajiaTang LichenHu Yan