Ask about this productRelated genes to: WBP2NL antibody
- Gene:
- WBP2NL NIH gene
- Name:
- WBP2 N-terminal like
- Previous symbol:
- -
- Synonyms:
- FLJ26145, MGC26816, PAWP, GRAMD7
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-06-22
- Date modifiied:
- 2015-11-17
Related products to: WBP2NL antibody
Related articles to: WBP2NL antibody
- One of the main factors contributing to aging is reactive oxygen species (ROS), which are produced by dysfunctional mitochondria. Reducing ROS generation is considered an essential treatment for senescence, but no effective treatment has been developed yet. In this study, vitisin B, a tetramer of resveratrol, was found to be an efficient reagent that reduces mitochondrial ROS generation after screening phenylpropanoids (PPs), metabolites produced to overcome ROS-mediated stress in plants. Vitisin B induced mitochondrial functional recovery by activating mitophagy and removing dysfunctional mitochondria. Mitochondrial functional recovery by vitisin B decreased mitochondrial ROS, a by-product generated from dysfunctional mitochondria. In addition, ROS reduction by vitisin B restored senescence-associated phenotypes. RNA sequencing identified WBP2 N-Terminal Like (WBP2NL) as a gene essential for vitisin B-mediated senescence rejuvenation. Knockdown of WBP2NL exhibited effects similar to those of vitisin B, reducing mitochondrial ROS generation and consequently reversing senescence-associated phenotypes. This study elucidates a novel mechanism by which vitisin B reverses senescence by lowering mitochondrial ROS generation. This discovery opens the way to new therapeutic options to control aging by modulating mitochondrial ROS production. - Source: PubMed
Publication date: 2026/01/21
Yoon Jee HeeLee Yun HaengOh SekyungLee Kyeong SeonPark Ji HoLee Yoo JinSo ByeonghyeonKim DuyeolKim MinseonKwon Hyung WookByun YoungjooLee Ki YongPark Joon Tae - The intestine is a multifunctional organ responsible for digestion, nutrient absorption, metabolic regulation, and innate immunity. In flatworms, recent studies have highlighted the importance of intestine-enriched genes expressed strongly in cells of the digestive tract. These genes are not only involved in digestion, nutrient uptake, transport, metabolism, and feeding behavior, but also in the modulating dynamics of stem cells (neoblasts). In , the molecular mechanisms regulating interaction between digestive and neural processes remain poorly understood, as in other free-living flatworms. Therefore, identifying the genes required for intestinal integrity and feeding behavior is essential for understanding the underpinning mechanisms. In this study, we examined intestine-enriched candidate genes predicted to be involved in cell differentiation and maintenance of the intestine in and whether the knockdown of these genes affects other tissues' functioning. Using RNAi-mediated gene silencing, we identified four genes (, , , and ) whose knockdown causes pronounced phenotypes, including reduced feeding, fasting behavior, decreased body size and cell proliferation, low reproduction, and altered expression of an intestine-specific apob promoter. We have characterized their roles in intestinal homeostasis and neoblast dynamics and discussed potential mechanisms linking gene disruption to changes in feeding behavior. - Source: PubMed
Publication date: 2025/12/11
Biryukov MikhailDmitrieva AnastasiaChepurnov GrigoryZadesenets Kira S - The duration-of-fertility (DF), which was defined as the number of days when breeding hens lay fertile eggs following copulation or artificial insemination (AI), is an important economic trait in chick production when it has strong effects on fertile egg output and production costs. Little is known about the underlying genes and molecular markers related to DF trait to date. Here, we measured the DF of 701 Chinese Jinghong hens and 408 Jingfen hens. The DF showed high individual variability and potential for genetic improvement. Then, 192 Jinghong breeding hens were provided for a genome-wide association study, 27 SNPs respectively located in three genomic linkage regions (GGA1:41Kb; GGA3:39Kb and GGA8:39Kb) were suggested to be significantly associated with DF. Particularly, 6 of these 27 SNPs were further verified to be associated with DF in the 701 Jinghong and 408 Jingfen hens using PCR-RFLP genotyping method. These 27 SNPs were also mapped to 7 genes according to their genomic position. Furtherly, 5 of these 7 genes were tested using qPCR. Results show that the CYP2D6, WBP2NL, ESR1 and TGFBR3 mRNA expression levels of hens with long DF were significantly higher than the hens with short DF (P < 0.05). Overall, findings in our research provide new insight into the genetic basis of duration-of-fertility in breeding hens while providing new clues for further functional validation on the DF-related genetic regulation mechanism and improvement of DF through chicken breeding. - Source: PubMed
Publication date: 2024/06/27
Luo WeiHuang XishiLi JingxuanGu Lantao - This study aims to investigate the gene expression of sperm-borne (), WW domain-binding protein 2N-Terminal Like (), and Tumor necrosis factor (), as a negative control, in spermatozoa and their relationship with fertility and seminal quality in stallions. Ejaculates from 40 Criollo stallions were used, whose fertility was assessed on the basis of their pregnancy rate per cycle in at least two breeding seasons. Pregnancy rates ranged from 20% to 90% and were used to divide the stallions into two groups: High rates (≥ 50%) (n = 25), and Low rates (< 50%) (n = 15). A computer-assisted sperm analysis system - (CASA) analyzed semen after collection. Also were evaluated the physical and functional integrity of the plasmatic membrane and sperm morphology alterations. All stallions expressed and . positively correlates with conception rate, total motility (TM), progressive motility (PM), plasmatic membrane functionality, and integrity. A simple linear regression was detected between pregnancy rate and expression (P = 0.003), TM (P < 0.001) and PM (P < 0.001). gene expression was higher (P = 0,012) in the High rates group than in the Low group. and did not correlate with seminal quality and stallion's fertility. It was concluded that gene expression in the spermatozoa might be used as a biomarker of fertility and seminal quality in stallions. Parameters of sperm kinetics also showed, positive correlation between TM, PM and pregnancy rate. - Source: PubMed
Publication date: 2024/04/12
Bueno Verônica La CruzBastos Henrique Boll de AraujoCenteno Luiz AugustoKretzmann Nélson AlexandreMattos Rodrigo CostaRechsteiner Sandra Fiala - Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of breast cancer. However, survival outcomes with tamoxifen are highly variable. The concentration of endoxifen, the 30-100 times more potent metabolite of tamoxifen and bioactivated by the CYP2D6 enzyme, has been described as the most relevant metabolite of tamoxifen metabolism. A genome-wide association study (GWAS) was performed with the objective to identify genetic polymorphisms associated with endoxifen serum concentration levels and clinical outcome in early-stage breast cancer patients receiving tamoxifen. A GWAS was conducted in 608 women of the CYPTAM study (NTR1509/PMID: 30120701). Germline DNA and clinical and survival characteristics were readily available. Genotyping was performed on Infinium Global Screening Array (686,082 markers) and single nucleotide polymorphism (SNP) imputation by using 1000 Genomes. Relapse-free survival during tamoxifen (RFSt) was defined the primary clinical outcome. Endoxifen serum concentration was analyzed as a continuous variable. Several genetic variants reached genome-wide significance (P value: ≤5 × 10). Endoxifen concentrations analysis identified 430 variants, located in TCF20 and WBP2NL genes (chromosome 22), which are in strong linkage disequilibrium with CYP2D6 variants. In the RFSt analysis, several SNP were identified (LPP gene: rs77693286, HR 18.3, 95% CI: 15.2-21.1; rs6790761, OR 18.2, 95% CI: 15.5-21.1). Endoxifen concentrations have a strong association with the chromosome 22, which contains the CYP2D6 gene. - Source: PubMed
Publication date: 2024/03/19
Sanchez-Spitman Anabel BeatrizBöhringer StefanDezentjé Vincent OlafGelderblom HansSwen Jesse JoachimGuchelaar Henk-Jan