Ask about this productRelated genes to: DLG7 antibody
- Gene:
- DLGAP5 NIH gene
- Name:
- DLG associated protein 5
- Previous symbol:
- DLG7
- Synonyms:
- KIAA0008, DLG1, HURP
- Chromosome:
- 14q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-19
- Date modifiied:
- 2016-05-24
Related products to: DLG7 antibody
Related articles to: DLG7 antibody
- At present, the known genetic causes of abnormal oocyte development can only account for a minority of female infertility. In our previous study, the mutation c.1101 C > G, p.Tyr367* in discs large-associated protein 5 (DLGAP5) was identified as a novel genetic cause of human oocyte maturation abnormality and female infertility. The present study aimed to validate the function of DLGAP5 in oocyte maturation and further explore the underlying mechanism by which DLGAP5 regulates oocyte meiosis. - Source: PubMed
Publication date: 2026/05/13
Wang MengZhou JuepuLi YouzhuLi ZhouLong RuiWang XiangfeiMao RuolinXu LeiCai LeiHan BingDong XiyuanGuo NaJin HuiziGao LiminAi JihuiXi QingsongJin LeiZhu Lixia - Microglia-mediated neuroinflammation plays a significant role in the pathogenesis of spinal cord injury (SCI). This study aimed to investigate the role of DLG associated protein 5 (DLGAP5) in SCI. - Source: PubMed
Publication date: 2026/05/08
Hui WenpengJiang YuanyuanWang XiaoShen Cailiang - Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor in adults and characterized by high therapeutic resistance and poor prognosis, in which the repair of DNA damage plays a significant role, highlighting the need to elucidate the regulatory mechanisms of DNA damage repair in GBM cells. The discs large homolog associated protein 5 (DLGAP5) is highly expressed and plays pro-tumoral activities in various cancers, however its roles in GBM remain poorly defined. Here, we report that DLGAP5 is significantly upregulated and associated with poor prognosis of GBM patients. In addition, DLGAP5 knockdown suppresses proliferation, induces apoptosis and causes DNA damage in GBM cells. Mechanistically, DLGAP5 knockdown leads to a decrease of E2F1-mediated transcription of DNA repair protein RAD51AP1, and importantly, the enforced expression of E2F1 recovers RAD51AP1 expression that largely rescues DNA damage and apoptosis of GBM cells depleted of DLGAP5. Furthermore, DLGAP5 knockdown reduces the expression of E2F1 and RAD51AP1 and induces DNA damage and suppresses tumorigenesis in xenografted GBM tumors. In conclusion, this study demonstrates that DLGAP5 protects against DNA damage in GBM cells through the E2F1/RAD51AP1 pathway, providing potential therapeutic targets in DNA damage-inducing anti-GBM modalities. - Source: PubMed
Publication date: 2026/04/17
Liu YujieChen RongLiu GexiChen JieZhou JingjieChen YanLi ZhiluLi YunyangDeng LongfeiCui Hongjuan - Hepatocellular carcinoma (HCC) often exhibits limited responsiveness to immune checkpoint inhibitors (ICIs), largely due to an immunosuppressive tumor microenvironment (TME). Regulated cell death (RCD) pathways, including ferroptosis, necroptosis, and pyroptosis, possess immunogenic properties that may influence tumor-immune interactions and therapeutic responses. However, the prognostic significance of RCD-related genes and their relationship with immune suppression and anti-PD-1 resistance remain insufficiently understood. Two bulk RNA-seq datasets (GSE181947 and GSE248516) representing immunologically distinct HCC subtypes were analyzed to identify differentially expressed genes (DEGs). These were intersected with curated ferroptosis-, necroptosis-, and pyroptosis-related gene sets, yielding 36 differentially expressed RCD-related genes (DE-RCDRGs). Functional enrichment, protein-protein interaction (STRING and CytoHubba), and survival analyses (Kaplan-Meier Plotter, TCGA-LIHC) were performed to prioritize hub genes. Clinical correlations and epigenetic regulation were assessed using UALCAN. Expression validation was conducted across 24 liver cancer cell lines using Human Protein Atlas (HPA) RNA-seq data. Additionally, deleterious non-synonymous SNPs (nsSNPs) in prioritized genes were structurally characterized using integrative in silico modeling. Ten hub genes were identified, with CEP55, DLGAP5, and EZH2 emerging as key prognostic markers. These genes were significantly overexpressed in tumors, associated with advanced stage and poor differentiation, and showed aberrant DNA methylation. Functional enrichment linked them to oxidative stress response, mitotic regulation, and epigenetic control. Cell-line analysis showed CEP55 and DLGAP5 enrichment in SNU-series models, while EZH2 was highly expressed in HuH-6, Hep3B, and Huh7. Structural analysis further identified deleterious nsSNPs affecting critical functional domains. CEP55, DLGAP5, and EZH2 are identified as RCD-associated biomarkers linked to immune suppression and immunotherapy resistance in HCC. - Source: PubMed
Publication date: 2026/04/15
Azanbayeva DinaraAli AwaisAbdelkarem OmneyaTouir GulnazAlgazina Togzhan - HPV types 16 and 18 are associated with 70% of invasive cervical cancers. Between these two types of HPV, HPV type 16 is more commonly found in cervical cancer patients, whereas HPV type 18 is less frequently reported. Currently, the molecular mechanism underlying the increased cancer risk in HPV type 16, compared to HPV type 18, has not yet been fully elucidated. - Source: PubMed
Publication date: 2026/04/01
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