Ask about this productRelated genes to: PARD6B antibody
- Gene:
- PARD6B NIH gene
- Name:
- par-6 family cell polarity regulator beta
- Previous symbol:
- -
- Synonyms:
- PAR-6B
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-01
- Date modifiied:
- 2014-11-18
Related products to: PARD6B antibody
Related articles to: PARD6B antibody
- Treatment response in first-episode psychosis (FEP) is highly variable, and reliable biomarkers for poor outcomes remain limited. MicroRNAs (miRNAs), important post-transcriptional regulators, have been implicated in psychotic disorders. However, genome-wide miRNA profiling and analyses of their downstream gene networks related to treatment response in FEP remain insufficiently explored. - Source: PubMed
Publication date: 2026/02/04
Yu Shun-ChunWang Yun-ChuLin Hsiu-PingJen Ya-WenHwang Tzung-JengLiu Chih-MinChan Hung-YuKuo Chian-JueYang Tsung-TsairWang Jen-PangLiu Chen-ChungHsieh Ming HLin Yi-TingChien Yi-LingKuo Po-HsiuShih Ya-WenYu Sung-LiangChen Hsuan-YuWang CharlotteChen Wei J - Retinal degenerative diseases (RDD) cause irreversible vision loss due to photoreceptor (PR) loss. Stem cell-derived PR precursors hold promise for retinal repair, but genetic labeling limits clinical translation. Surface marker-based sorting offers a safer alternative. - Source: PubMed
Publication date: 2025/12/07
Wang ChengangChen MinFang YajieFu YunzhaoLv YingxueZhang XueLi BowenBai YihanLi QiyouZeng YuxiaoHe Xiang-YuLiu HonglingLiu Yong - Identifying effective compounds to restore the polarity of absorptive enterocytes (AEs) holds promise for mitigating the severity and duration of small intestinal disorders. Spermidine (SPD) is a natural polyamine; whether it can repair inflammation-induced loss of AE polarity remains unclear. In this study, we employed lipopolysaccharide (LPS)-challenged mice models combined with 4D data-independent acquisition (DIA) proteomics to investigate the mechanisms by which SPD alleviates polarity loss in AEs. Our results demonstrated that SPD supplementation enhanced the antioxidant capacity and improved the villus/crypt ratio in the jejunum of LPS-treated mice. Proteomic analysis revealed that LPS induced acute phase and inflammatory responses, significantly downregulating the expression of cytoskeletal proteins (Pdlim3, Pdlim7) essential for epithelial morphology as well as proteins involved in apical-basal polarity (Pard6b, Pard3, Prkcz, LLGL2), apical membrane integrity (Vil1, Pdims, Akp3, Tjps, Pards), and apical SLC transporters. Conversely, SPD attenuated mucosal- and tissue-specific immune responses and reversed the downregulation of these protein groups. Furthermore, using a Caco-2 cell model, we confirmed the anti-inflammatory effect of SPD and elucidated its role in suppressing AE polarity loss via the regulation of HDAC4 signaling. These findings indicate that SPD effectively alleviates the inflammation-induced loss of AE polarity in the jejunum of LPS-challenged mice. - Source: PubMed
Publication date: 2025/11/24
Zheng PengchaoTian ShiyiChen ZhenZhang YiJiang KeyiZha ZiyangWang JueLiu Baosheng - Partitioning-defective protein 6 (Par6), is a core regulator of cell polarity whose dysregulation is increasingly implicated in tumorigenesis and progression. This review aims to elucidate the molecular basis by which Par6 promotes tumor development in various cancer types. We first review the molecular structure of PAR6 and its general functions in normal cells, summarize the distinct expression patterns of Par6 isoforms (Pard6a, Pard6b, Pard6g) in different tumors and their divergent clinical implications. Subsequently, starting from the tumor biological functions of Par6, we elaborate in detail on the molecular interactions of PAR6 in tumor polarization and growth. In the TGF-β signaling pathway, phosphorylation of Par6 promotes RhoA degradation, thereby driving tumor cell epithelial-mesenchymal transition (EMT) and metastasis. Additionally, Par6 engages in crosstalk with multiple signaling pathways such as PI3K/Akt, MAPK/ERK, and Wnt, collectively coordinating the loss of cell polarity and malignant progression in tumors. Furthermore, we highlight emerging regulatory dimensions, including the dephosphorylation of the Par6 complex by phosphatases such as PP2A and PHLPP, which represent novel targets for therapeutic intervention. By integrating these aspects, this review provides a comprehensive and mechanistic framework for understanding the multifaceted roles of Par6 in cancer and underscores its potential as a diagnostic biomarker and therapeutic target. - Source: PubMed
Publication date: 2025/10/17
Xu WeiFang YilinLi KaixuanZhang XiaotingGe YumeiLi Kaiqiang - Despite the critical role of endocytosis-related genes in oncogenic processes, research exploring their potential for prognosticating hepatocellular carcinoma (HCC) remains limited. Establishing a connection between endocytosis and HCC is imperative. This study aimed to create a gene signature related to endocytosis to identify HCC subtypes and predict outcomes. - Source: PubMed
Publication date: 2025/06/27
Zhang LitingZhou DanGao XiaoqinLi JunfengXie Xiaodong