Ask about this productRelated genes to: PARD6B antibody
- Gene:
- PARD6B NIH gene
- Name:
- par-6 family cell polarity regulator beta
- Previous symbol:
- -
- Synonyms:
- PAR-6B
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-01
- Date modifiied:
- 2014-11-18
Related products to: PARD6B antibody
Related articles to: PARD6B antibody
- Fibro-adipogenic progenitor (FAP) dysfunction drives skeletal muscle fibrosis in type 2 diabetes mellitus (T2DM), yet the underlying metabolic-epigenetic mechanisms remain poorly understood. This study investigates how metabolite fluctuations regulate the cell fate of CD90 FAPs in the diabetic skeletal muscles. - Source: PubMed
Publication date: 2026/08/10
Tong Zhou-JieLi Yi-HuiSong MingSheng Ya-NanWu Yan-ZhaoShang Yuan-YuanHu Bo-AngLu BinZhu PingWang Gan-QiZhan Hao-JieHan LuZhang WeiWang Zhi-HaoZhong Ming - Cell-cell junctions (CCJs) are essential for maintaining epithelial integrity, and adhesion-related molecules have long been implicated in breast cancer progression. However, the subtype-specific prognostic significance of CCJ-related gene expression patterns within individual intrinsic breast cancer subtypes has not been systematically characterized. We analyzed 179 genes annotated to the Gene Ontology term "cell-cell junction organization" (GO:0045216) across intrinsic breast cancer subtypes using the METABRIC and The Cancer Genome Atlas (TCGA) datasets. Subtype-specific prognostic CCJ genes were identified using multivariate Cox proportional hazards models for disease-specific survival and integrated into CCJ gene expression signatures. The prognostic performance was validated in an independent cohort (SCAN-B). Elevated CCJ signature scores were associated with poorer survival across subtypes, with particularly strong effects in Luminal B (LumB) and Basal-like (Basal) tumors. Person-year analyses indicated that high CCJ scores predicted an increased incidence of early recurrence (0-5 years) in these aggressive subtypes. Pathway enrichment analyses revealed that high-score tumors exhibited upregulation of extracellular matrix organization and matrisome-related pathways. Single-cell RNA sequencing further demonstrated that LumB CCJ genes (e.g., PARD6B, CDH3) were predominantly expressed in tumor epithelial cells, whereas the Basal CCJ signature reflected contributions from epithelial (e.g., MARVELD2) and endothelial (e.g., RAMP2) cells. Collectively, CCJ signatures stratify prognosis and capture subtype-specific cellular and microenvironmental features in breast cancer. - Source: PubMed
Publication date: 2026/06/29
Ishii HayatoNishiyama KyokaNakahara AyakaTamori ShomaOhno ShigeoSasaki KazunoriAkimoto Kazunori - Invasive micropapillary carcinoma (IMPC) of the breast, a rare and aggressive subtype, represents a unique morphology of reversed polarity with higher metastatic propensity. Due to the limited availability of experimental models, understanding distinct molecular pathways and potential therapeutic targets remains challenging. This study aimed to establish patient-derived cell cultures (PDCs) from IMPC to generate viable models for in-vitro studies. Tissue samples from five IMPC cases were enzymatically disaggregated using five different cell disaggregation protocols. These cells were characterized using immunofluorescence, short tandem repeats profiling, and real-time assays for tumor marker expression profiles. RNA sequencing was performed and compared with invasive ductal carcinoma, no special type (IDC-NST), to study differential gene expression and cell polarity markers. Two short-term PDCs were successfully established from IMPC samples with an optimized collagenase-based protocol. These cultures showed an immunohistochemical profile consistent with the original tumor tissues and maintained hormone receptor and MUC1 expression status. RNA sequencing of PDCs revealed similar gene expression patterns with matched tumor tissue and revealed upregulated RAP1, MAPK, and PI3K-AKT pathways, when compared with ER/PR-matched IDC. These PDCs also showed different gene expression patterns in cell-polarity associated genes, such as cadherins CDH2, tight junction gene MARVELD2, PAR complex gene PARD6B, and downregulation of the cell polarity CRB2 gene. This study indicated the need for an optimization of cell culture conditions and the feasibility of establishing patient-derived cell cultures from IMPC. These models provide a great tool to study molecular insights, cell polarity, and therapeutic research in a rare breast cancer subtype. - Source: PubMed
Gurav MamtaShetty OmshreeJoshi ShalakaGulia SeemaChaubal RohanGupta SudeepShet Tanuja - Treatment response in first-episode psychosis (FEP) is highly variable, and reliable biomarkers for poor outcomes remain limited. MicroRNAs (miRNAs), important post-transcriptional regulators, have been implicated in psychotic disorders. However, genome-wide miRNA profiling and analyses of their downstream gene networks related to treatment response in FEP remain insufficiently explored. - Source: PubMed
Publication date: 2026/02/04
Yu Shun-ChunWang Yun-ChuLin Hsiu-PingJen Ya-WenHwang Tzung-JengLiu Chih-MinChan Hung-YuKuo Chian-JueYang Tsung-TsairWang Jen-PangLiu Chen-ChungHsieh Ming HLin Yi-TingChien Yi-LingKuo Po-HsiuShih Ya-WenYu Sung-LiangChen Hsuan-YuWang CharlotteChen Wei J - Retinal degenerative diseases (RDD) cause irreversible vision loss due to photoreceptor (PR) loss. Stem cell-derived PR precursors hold promise for retinal repair, but genetic labeling limits clinical translation. Surface marker-based sorting offers a safer alternative. - Source: PubMed
Publication date: 2025/12/07
Wang ChengangChen MinFang YajieFu YunzhaoLv YingxueZhang XueLi BowenBai YihanLi QiyouZeng YuxiaoHe Xiang-YuLiu HonglingLiu Yong