Ask about this productRelated genes to: SPAG8 antibody
- Gene:
- SPAG8 NIH gene
- Name:
- sperm associated antigen 8
- Previous symbol:
- -
- Synonyms:
- hSMP-1, HSD-1, BS-84, SPAG3, CT142
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-10
- Date modifiied:
- 2015-04-30
Related products to: SPAG8 antibody
Related articles to: SPAG8 antibody
- BACKGROUND: Understanding the genetic basis of adaptation to extreme environments is crucial in evolutionary biology. Gannan Tibetan sheep, which thrive in high altitudes with thin air and cold climates, demonstrate remarkable resilience. However, the genetic basis of their adaptations remains poorly understood. In this study, we conducted whole-genome resequencing of three indigenous Tibetan sheep breeds, including Ganjia (n = 12), Oula (n = 12), Kecai (n = 12), from the Gannan Tibetan Autonomous Prefecture (average altitude of 3,500 m) in China. By integrating our data with previously published genomic data of sheep from northern China (Altitude below 1,500 m), we examined the genetic population structure, ancestry components, and signatures of positive selection. RESULTS: Our analyses, including principal component analysis, neighbor-joining tree construction, and ADMIXTURE, revealed that the three indigenous Tibetan sheep breeds share a common ancestry with other Tibetan sheep breeds, yet exhibit distinct population differentiation. Moreover, all three breeds display high genetic diversity, which enhances their adaptation to harsh local environments. Through selective sweep analysis, we identified genes associated with cold tolerance and high-altitude adaptation. These genes are involved in mitochondrial function and oxidative stress (LONP1, NDUFA11, NDUFB4 and HSD11B1L), cardiorespiratory and vascular function (FECH, TNFAIP3), and fat metabolism and thermogenesis (ACSL6, PDGFD, CES3, MTCH2, TMEM8B, SPAG8, ETAA1, ZIC1, ATG5, and HAO2). Additionally, we identified candidate regions containing genes related to immunity and physical traits. CONCLUSION: This study provides a comprehensive overview of the genomic variations, ancestry compositions, and selective signals linked to high-altitude traits in Gannan indigenous Tibetan sheep. Our findings offer valuable insights into the breeding and management of Tibetan sheep. - Source: PubMed
Publication date: 2026/03/27
Lv ChenxiaoChen LiliZou PanChen YanMa Yi - Perfluoroalkyl and poly-fluoroalkyl substances (PFAS) are pervasive environmental pollutants and potential threats to reproductive health. Epidemiological studies have established an association between PFAS and male infertility, but the underlying mechanisms are unclear. - Source: PubMed
Kumaresan ArumugamYadav PankajSinha Manish KumarNag PradeepJohn Peter Ebenezer Samuel KingMishra Jay SKumar Sathish - Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with reduced quality of life and earlier mortality, but its pathogenesis and key genes are still unclear. In this investigation, bioinformatics was used to deeply analyze the pathogenesis of IPF and related key genes, so as to investigate the potential molecular pathogenesis of IPF and provide guidance for clinical treatment. Next-generation sequencing dataset GSE213001 was obtained from Gene Expression Omnibus (GEO), and the differentially expressed genes (DEGs) were identified between IPF and normal control group. The DEGs between IPF and normal control group were screened with the DESeq2 package of R language. The Gene Ontology (GO) and REACTOME pathway enrichment analyses of the DEGs were performed. Using the g:Profiler, the function and pathway enrichment analyses of DEGs were performed. Then, a protein-protein interaction (PPI) network was constructed via the Integrated Interactions Database (IID) database. Cytoscape with Network Analyzer was used to identify the hub genes. miRNet and NetworkAnalyst databaseswereused to construct the targeted microRNAs (miRNAs), transcription factors (TFs), and small drug molecules. Finally, receiver operating characteristic (ROC) curve analysis was used to validate the hub genes. A total of 958 DEGs were screened out in this study, including 479 up regulated genes and 479 down regulated genes. Most of the DEGs were significantly enriched in response to stimulus, GPCR ligand binding, microtubule-based process, and defective GALNT3 causes HFTC. In combination with the results of the PPI network, miRNA-hub gene regulatory network and TF-hub gene regulatory network, hub genes including LRRK2, BMI1, EBP, MNDA, KBTBD7, KRT15, OTX1, TEKT4, SPAG8, and EFHC2 were selected. Cyclothiazide and rotigotinethe are predicted small drug molecules for IPF treatment. Our findings will contribute to identification of potential biomarkers and novel strategies for the treatment of IPF, and provide a novel strategy for clinical therapy. - Source: PubMed
Publication date: 2023/11/21
Giriyappagoudar MuttanagoudaVastrad BasavarajHorakeri RajeshwariVastrad Chanabasayya - Signature of selection studies have identified many genomic regions with known functional importance and some without verified functional roles. Multiple studies have identified Transmembrane protein 8B ( as having been recently under extreme selection pressure in domesticated sheep, but no study has provided sheep phenotypic data clarifying a reason for extreme selection. We tested for production trait association in 770 U.S. Rambouillet, Targhee, Polypay, and Suffolk sheep. was associated with mature weight at 3 and 4 years ( < 0.05). This suggested selection for sheep growth and body size might explain the historical extreme selection pressure in this genomic region. We also tested Sperm-associated antigen 8 () encoding a G493C substitution. While this variant was associated with mature weights at ages 3 and 4, it was not as strongly associated as Transmembrane protein 8B has little functional information except as an inhibitor of cancer cell proliferation. To our knowledge, this is the first study linking to whole organism growth and body size under standard conditions. Additional work will be necessary to identify the underlying functional variant(s). Once identified, such variants could be used to improve sheep production through selective breeding. - Source: PubMed
Publication date: 2020/12/15
Cinar Mehmet UlasMousel Michelle RHerndon Maria KTaylor J BretWhite Stephen N - The objective of genome mapping is to achieve valuable insight into the connection between gene variants (genotype) and observed traits (phenotype). Part of that objective is to understand the selective forces that have operated on a population. Finding links between genotype-phenotype changes makes it possible to identify selective sweeps by patterns of genetic variation and linkage disequilibrium. Based on Illumina 50KSNP chip data, two approaches, XP-EHH (cross-population extend haplotype homozygosity) and F (fixation index), were carried out in this research to identify selective sweeps in the genome of three Iranian local sheep breeds: Baluchi (n = 86), Lori-Bakhtiari (n = 45) and Zel (n = 45). Using both methods, 93 candidate genomic regions were identified as harboring putative selective sweeps. Bioinformatics analysis of the genomic regions showed that signatures of selection related to multiple candidate genes, such as HOXB9, HOXB13, ACAN, NPR2, TRIL, AOX1, CSF2, GHR, TNS2, SPAG8, HINT2, ALS2, AAAS, RARG, SYCP2, CAV1, PPP1R3D, PLA2G7, TTLL7 and C20orf10, that play a role in skeletal system and tail, sugar and energy metabolisms, growth, reproduction, immune and nervous system traits. Our findings indicated diverse genomic selection during the domestication of Iranian sheep breeds. - Source: PubMed
Publication date: 2019/03/18
Manzari ZMehrabani-Yeganeh HNejati-Javaremi AMoradi M HGholizadeh M