Ask about this productRelated genes to: PGDS antibody
- Gene:
- HPGDS NIH gene
- Name:
- hematopoietic prostaglandin D synthase
- Previous symbol:
- -
- Synonyms:
- GSTS, PGDS, H-PGDS, PGD2, GSTS1-1, GSTS1
- Chromosome:
- 4q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2009-07-14
- Date modifiied:
- 2016-10-05
- Gene:
- PTGDS NIH gene
- Name:
- prostaglandin D2 synthase
- Previous symbol:
- -
- Synonyms:
- PGDS, L-PGDS
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-13
- Date modifiied:
- 2016-10-05
Related products to: PGDS antibody
Related articles to: PGDS antibody
- Physical activity (PA) and sedentary behavior (SB) are associated with many diseases, including Alzheimer disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. This study aims to address this gap, with a specific focus on all-cause dementia. - Source: PubMed
Publication date: 2026/01/23
Arani GayatriArora AmitYang ShuaiWu JingyueKraszewski Jennifer NMartins AmyMiller AlexandraZeba ZebunnesaJafri AyanHu ChengchengFarland Leslie VBea Jennifer WColetta Dawn KAslan Daniel HSayre M KatherineBharadwaj Pradyumna KAlly MadelineMaltagliati SilvioLai Mark H CWilcox RandDE Geus EcoAlexander Gene ERaichlen David AKlimentidis Yann C - Tumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single-cell RNA data, to explore the metabolic landscape of tumor microenvironment (TME) in lung adenocarcinoma (LUAD) and identify novel metabolite signaling axis. - Source: PubMed
Publication date: 2025/05/22
Liu QiangChen HuiguoTang DongfangZhang HuibiaoChen ShaogengMeng YiranZheng BoyingLiu FeiZhou JingZhang Wen - Physical activity (PA), including sedentary behavior, is associated with many diseases, including Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. To address this knowledge gap, we first assessed the conventional observational associations of three self-reported and three device-based PA measures with circulating levels of 2,911 plasma proteins measured in the UK Biobank (n=39,160) and assessed functional enrichment of identified proteins. We then used bi-directional Mendelian randomization (MR) to further evaluate the evidence for causal relationships of PA with protein levels. Finally, we performed mediation analyses to identify proteins that may mediate the relationship of PA with incident all-cause dementia. Our findings revealed 41 proteins consistently associated with all PA measures and 1,027 proteins associated with at least one PA measure. Both conventional observational and MR study designs converged on proteins that appear to increase as a result of PA, including integrin proteins such as ITGAV and ITGAM, as well as MXRA8, CLEC4A, CLEC4M, GFRA1, and ADGRG2; and on proteins that appear to decrease as a result of PA such as LEP, LPL, INHBC, CLMP, PTGDS, ADM, OGN, and PI3. Functional enrichment analyses revealed several relevant processes, including cell-matrix adhesion, integrin-mediated signaling, and collagen binding. Finally, several proteins, including GDF15, ITGAV, HPGDS, BCAN, and MENT, were found to mediate the relationship of PA with all-cause dementia, implicating processes such as synaptic plasticity, neurogenesis and inflammation, through which PA protects against dementia. Our results provide insights into how PA may affect biological processes and protect from all-cause dementia, and provide avenues for future research into the health-promoting effects of PA. - Source: PubMed
Publication date: 2025/01/31
Arani GayatriArora AmitYang ShuaiWu JingyueKraszewski Jennifer NMartins AmyMiller AlexandraZeba ZebunnesaJafri AyanHu ChengchengFarland Leslie VBea Jennifer WColetta Dawn KAslan Daniel HSayre M KatherineBharadwaj Pradyumna KAlly MadelineMaltagliati SilvioLai Mark H CWilcox Randde Geus EcoAlexander Gene ERaichlen David AKlimentidis Yann C - Tibial dyschondroplasia (TD) is an intractable avian cartilage disease in which proximal growth plates of tibia lack blood vessels and contain nonviable cells, and it leads to the inflammatory response. Prostaglandins (PGs) genes have not been studied yet in TD chicken, and they might play role in skeletal metabolism, therefore we planned to explore the role of recombinant glutathione-S-transferase A3 (rGSTA3) protein and PG-related genes. In this study, qRT-PCR, enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) analysis were used to identify the expression patterns of eight PG-related genes in the tibial growth plate of broiler chicken. The results showed that the expression of PG-related genes glutathione-S-transferase A3 (GSTA3), cyclooxygenase 2 (COX-2), prostaglandin D2 synthase (PTGDS), prostaglandin E synthase (PTGES), prostaglandin E2 receptor (PTGER) 3, PTGER4, prostaglandin reductase 1 (PTGR1) and hematopoietic prostaglandin D synthases (HPGDS) expression were identified and could significantly respond to thiram-induced TD chicken. Interestingly, the expression of rate-limiting enzyme COX-2 and PGE were induced after the treatment of rGSTA3 protein. These findings demonstrated that the occurrence of TD is closely related to the inhibition of PGs. Moreover, rGSTA3 protein participated in the recovery of TD by strengthening the expression of PG-related genes. - Source: PubMed
Publication date: 2020/10/21
Niu SLi XJahejo A RZhang NYang S XJia Y FZhang Y YTian Z XLi ZNing G BZhang DTian W X - Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, aspirin sensitivity, and asthma. This study aims to identify a mechanism to target for the future treatment of AERD via the elucidation of the effect of systemic steroids on the expression of hematopoietic prostaglandin D synthase (HPGDS) and chemotaxic prostaglandin D (DP2) receptor relative to eosinophil activation in the nasal polyps of patients with AERD. - Source: PubMed
Publication date: 2020/02/20
Suzuki NorioKo-Mitamura Elizabeth PInui TakakiTerada TetsuyaDejima KenjiNagata NanaeUrade YoshihiroKawata Ryo