Ask about this productRelated genes to: TMEM173 antibody
- Gene:
- TMEM173 NIH gene
- Name:
- transmembrane protein 173
- Previous symbol:
- -
- Synonyms:
- FLJ38577, NET23, ERIS, MPYS, STING, MITA
- Chromosome:
- 5q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-24
- Date modifiied:
- 2019-04-23
Related products to: TMEM173 antibody
Related articles to: TMEM173 antibody
- Chronic inflammation-driven gastric precancerous lesions (GPL) are characterized by progressive immune remodeling toward an immunosuppressive state, yet effective chemopreventive agents targeting this process remain scarce. Here, we identify asiatic acid (AA), a natural pentacyclic triterpenoid, as a STING‑binding compound that contributes to reshaping the gastric immune microenvironment and interfering with the Correa cascade. - Source: PubMed
Publication date: 2026/08/20
Li HaotianShen LiLiu JiabaoSu XiaolanMeng ManYang JianqinChen RunhuaYang ChenLiu Yanjun - Cancer-associated fibroblasts comprise diverse functionally distinct cellular subsets, with certain subpopulations exerting pivotal influence in shaping the pancreatic cancer immune microenvironment. Here we show that Lin28b cancer-associated fibroblasts contribute to establishing an immunologically cold tumor microenvironment in pancreatic ductal adenocarcinoma. Mechanistically, Lin28b directly binds to STING mRNA and promotes its degradation, thereby suppressing STING expression and downstream type I interferon signaling. Loss of Lin28b in cancer-associated fibroblasts activates the cGAS-STING-interferon signaling cascade, enhancing dendritic cell antigen presentation and CD8 T cell cytotoxic function. Importantly, genetic inhibition of Lin28b in cancer-associated fibroblasts enhances sensitivity to anti-PD-L1 immune checkpoint blockade therapy. These findings reveal that targeting the Lin28b-STING axis represents a promising therapeutic strategy for overcoming the intrinsic resistance of pancreatic ductal adenocarcinoma to immunotherapy. - Source: PubMed
Publication date: 2026/08/07
Fan MingheZhang ZiyangXu WeiLiu YuweiWang RuoxuanHao WenqinHuo SihanGuo YuyaoWang LinaLv AngLiu XiangyuWang WeiHan ChuanhuiZhao Ying - The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a central cytosolic DNA sensor that mediates innate immunity by inducing type I interferons (IFN-I) and proinflammatory cytokines. Although its role in antiviral defense and tumor immunity has been well established, emerging evidence suggests that it is also closely involved in demyelinating diseases of both the central and peripheral nervous systems (PNS). Such diseases, exemplified by multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), are characterized by immune-mediated inflammation, oxidative stress, mitochondrial dysfunction, and impaired myelin regeneration. This review systematically examines the diverse roles of the cGAS-STING pathway in demyelination. We summarize how moderate activation of this pathway promotes protective inflammation and autophagy, facilitating debris clearance and supporting remyelination during the early stages of disease. In contrast, excessive or sustained activation exacerbates neuroinflammation, hinders remyelination, and promotes progressive axonal injury. The involvement of cGAS-STING in T cell polarization, reactive oxygen species (ROS)-mediated injury, and antiviral responses further underscores its dual role in both disease initiation and progression. Understanding the context-dependent effects of cGAS-STING signaling in demyelinating diseases offers valuable insights for developing targeted therapeutic strategies. However, this review also emphasizes that most current evidence is derived from cellular and animal models. Given that the effects of cGAS-STING signaling are highly context dependent and may vary among different demyelinating diseases, disease stages, and cell types, further clinically relevant studies are required to validate its therapeutic potential. - Source: PubMed
Publication date: 2026/09/02
Chen XiYu XinguiCao XinyiFeng JiayuMeng ZijieWang Xiaohong - Cancer remains a major therapeutic challenge due to drug resistance and metastasis, processes driven by oxidative stress and redox imbalance. Targeting this vulnerability through ferroptosis (iron-dependent lipid peroxidation) and cuproptosis (copper-driven mitochondrial dysfunction), two ROS-mediated cell death pathways, offers a promising therapeutic strategy. However, clinical translation is hindered by incomplete understanding of their redox regulation and limited immunogenicity. - Source: PubMed
Publication date: 2026/09/01
Deng XiaoyiDeng ZaidongZhu BinHu RuiqiMa JingLi ChanghengZhang PuLi LeiYang HuiLiu YuYu Yanxun VJin Youngnam N - Lactate, known for its metabolic functions, has recently emerged as a signaling molecule. In a recent issue of Immunity, Guo and colleagues report that lactate is a competitive antagonist of STING and propose an epidermal growth factor receptor (EGFR)-mediated signaling cascade that enhances lactate dehydrogenase A (LDHA) activity, lactate production, and immunosuppression.. - Source: PubMed
Tian YuanCai Xin