Ask about this productRelated genes to: GSDML antibody
- Gene:
- GSDMB NIH gene
- Name:
- gasdermin B
- Previous symbol:
- GSDML
- Synonyms:
- PRO2521
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-09
- Date modifiied:
- 2016-10-05
Related products to: GSDML antibody
Related articles to: GSDML antibody
- Pyroptosis, a form of inflammatory programmed cell death, plays a dual role in tumor progression and anti-tumor immunity. Its comprehensive clinical and biological significance in intrahepatic cholangiocarcinoma (iCCA) remains to be elucidated. - Source: PubMed
Publication date: 2026/05/07
Zhao BinhanZhu YongjiJin ZiyangLi XiangLin KainanWang YifanLu YunkunHua Wen - Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear. - Source: PubMed
Publication date: 2026/03/27
Foppiano FrancescoBöck AndreasBeerweiler ClaudiaUrner KathrinEge MarkusSchmausser-Hechfellner ElisabethSkevaki ChrysanthiFrey UrsRiedler JosefFrei RemoLauener RogerRoduit CarolineKarvonen Anne MRoponen MarjutPekkanen JuhaDivaret-Chauveau AmandineBarnig CindyVon Mutius ErikaSchaub Bianca - Bladder cancer (BC) is one of the most common urinary tract malignancies. In recent years, increasing attention has been paid to the role of pyroptosis-an inflammatory form of programmed cell death-in cancer development. Gasdermin B (GSDM B), a member of the gasdermin protein family, is involved in the regulation of inflammatory processes and the immune response, and its expression may be associated with cancer development and progression. The aim of the study was to assess GSDM B concentrations in the serum of patients with bladder cancer and to determine its potential diagnostic value in comparison with the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). This study included patients with bladder cancer hospitalized at the Department of Urology, Medical University of Białystok, and a healthy control group. GSDM B concentrations were determined by Enzyme-Linked Immunosorbent Assay (ELISA), while CEA and CA19-9 concentrations were determined by chemiluminescent microparticle immunoassay (CMIA). Concentrations in the serum of patients with bladder cancer were significantly higher than in the control group. A positive correlation was found between GSDM B and CEA and CA19-9 concentrations, as well as the age of the subjects. Receiver-operating characteristic (ROC) analysis demonstrated moderate but significant diagnostic value of GSDM B in differentiating patients with BC from healthy controls. No significant differences in GSDM B concentrations were observed between low- and high-grade tumors. These findings suggest that GSDM B may serve as a potential diagnostic marker for bladder cancer, particularly when used as part of a multimarker panel. - Source: PubMed
Publication date: 2026/04/16
Pączek SaraOlkowicz MichałKudelski JacekGudowska-Sawczuk Monika - Archaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contribution to DNA virus defense remains poorly understood. Here, we investigate the contribution of Neandertal- and Denisovan-introgressed haplotypes to viral load of five common DNA viruses in UK Biobank samples, using genome-wide association summary statistics. We identified 18 genome-wide significant associations, predominantly involving Epstein-Barr virus (EBV) and loci within the Major Histocompatibility Complex, including a Denisovan-like haplotype tightly linked to HLA-A*11:01. Notably, the archaic alleles of these haplotypes showed a directional bias toward increased viral loads. Focusing on two chromosome 17 haplotypes associated with higher EBV load, we identified phenotypic associations with blood cell traits and disease markers, as well as functional effects on immune-relevant genes, including GSDMB, ARRB2, and ALOX15. Allele frequency analysis of one of the chromosome 17 haplotypes revealed signatures of shifting modes of selection, possibly reflecting changes in pathogen landscapes over time. Our results suggest that archaic DNA systematically contributes to DNA virus immunity in modern humans, with effects distinct from previously described RNA virus associations. These findings provide novel evolutionary and functional insights into host-virus interactions and the role of archaic admixture in antiviral defense. - Source: PubMed
Publication date: 2026/04/28
Rajpara RutviPolishchuk Sofiia StefaniiaYermakovich DanatDannemann Michael - Non-T2 asthma is currently defined by missing parameters, such as low blood eosinophils and FeNO, rather than positively identifiable mechanistic features. This definition overlaps with paucigranulocytic asthma (PGA). However, T2-biomarkers fluctuate over time, especially during glucocorticoid therapy, leading to potential over-diagnosis of T2-low asthma. Advancing beyond traditional endotyping is required for precision medicine. - Source: PubMed
Publication date: 2026/03/27
Poto RemoChan RoryBreda DanielaVarricchi GildaBurastero Samuele E