Ask about this productRelated genes to: PSMA3 antibody
- Gene:
- PSMA3 NIH gene
- Name:
- proteasome subunit alpha 3
- Previous symbol:
- -
- Synonyms:
- HC8
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-03
- Date modifiied:
- 2016-10-05
Related products to: PSMA3 antibody
Related articles to: PSMA3 antibody
- Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 9 (NSP9), the viral RNA-dependent RNA polymerase (RdRp), is essential for viral replication but its comprehensive host interactome remains uncharacterized. This study employed co-immunoprecipitation coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to systematically identify NSP9-associated host proteins. We identified 222 high-confidence host interactors, with Gene Ontology and KEGG pathway analyses revealing significant enrichment in RNA/DNA-binding proteins, ubiquitin-proteasome pathways, metabolic regulators (amino acid/lipid biosynthesis), endoplasmic reticulum processing, and cell cycle components. Protein-protein interaction network analysis further delineated six functional modules involved in RNA processing, vesicular transport, and innate immunity. Crucially, validation studies confirmed direct binding between NSP9 and key candidates (CAPZ1, PSMA3, CDK1, USP48). Functional assessment demonstrated that CDK1 overexpression significantly inhibited PRRSV replication, implicating CDK1 as a host restriction factor. These findings collectively unveil the multifaceted role of NSP9 in subverting host machinery while identifying novel host defense mechanisms and potential targets for antiviral development against PRRSV. - Source: PubMed
Publication date: 2025/12/05
Wen WeiLiu YuhangWang WenqiangZhu ZhenbangLi Xiangdong - Nasopharyngeal carcinoma (NPC), highly prevalent in southern China, often leads to treatment failure in advanced stages due to recurrence or metastasis. While METTL14 plays a crucial role in cancer, its regulation of immune- and inflammation-related genes remains poorly understood. This study aims to investigate whether METTL14 is involved in regulating the expression of genes associated with tumor necrosis factor (TNF), interferon (IFN), interleukin (IL), and MHC class I in NPC cells. - Source: PubMed
Zhou ZhihaoWang JingShen LingjunHan LiuxinLi QiwenWu AibingLi JingLiang ZumingZhu LitongHe DanhuaZhou YingHuang ShihaoZhao ZhanlinCong JingePeng ZhitaoZhao PingYe ShunaBai BinyiHong XuanjiaDai GuanqiLei YeZhao WentaoJia JunshuangLin XiaolinXiao DongZhang YuqinLin Taoyan - Prostate adenocarcinoma (PRAD) is asymptomatic in the early stages and most patients are diagnosed at an advanced stage, which leads to a poor prognosis. Therefore, an effective prognostic marker is required to improve PRAD prognosis. - Source: PubMed
Publication date: 2025/07/12
Cao MuyangLi JinZhang JianbinLu Wenlong - Coagulation system abnormalities contribute to clinical manifestations in preeclampsia (PE), but the mechanisms of coagulation and fibrinolysis in PE are unclear. We utilized the Gene Expression Omnibus (GEO) database to obtain the GSE10588 training set and GSE54618 validation set. From GeneCards, we extracted 514 coagulation and fibrinolysis-related genes (CFRGs). Differential expression analysis identified 1521 DEGs in the GSE10588 training set. WGCNA revealed the salmon module (778 genes) as the key module. LASSO and SVM-RFE methods identified four biomarkers (CYP19A1, C1QBP, GHR, and PSMA3) for a diagnostic model. GSEA was performed on the biomarkers. Immune cell infiltration and therapeutic agents for the biomarkers were analyzed. A circRNA-miRNA-mRNA network was constructed. The salmon module showed the highest correlation with PE and normal samples. The diagnostic model comprised CYP19A1, C1QBP, GHR, and PSMA3. Immune cell analysis revealed significant differences, including type 2 T helper cells and regulatory T cells. C1QBP correlated positively with effector memory CD4 T cells, while PSMA3 had a negative correlation with CD56dim natural killer cells. Sixty-one potential therapeutic agents were predicted, as well as n circRNA-miRNA-mRNA network composed of 73 nodes and 88 edges. Our bioinformatic analysis resulted in a diagnostic model (CYP19A1, C1QBP, GHR, and PSMA3) for PE related to coagulation and fibrinolysis. We also conducted immune microenvironment and drug sensitivity analyses, providing insights into PE diagnosis and treatment. - Source: PubMed
Publication date: 2025/06/23
Liu YujieChen TingtingFan Cuifang - Long non-coding RNAs (lncRNAs) have shown increasing potential as biomarkers and therapeutic targets in cancer. Among them, PSMA3-AS1 has garnered significant attention due to its dysregulated expression in various human malignancies and its involvement in key oncogenic processes. This review offers a comprehensive analysis of PSMA3-AS1, including its expression patterns, molecular mechanisms, and clinical significance across different cancer types. It explores its abnormal expression levels, correlation with clinicopathological characteristics, and roles in promoting cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT). The review delves into the molecular pathways through which PSMA3-AS1 exerts its functions, particularly its interactions with microRNAs. Highlighting its strong potential as both a diagnostic and prognostic biomarker, the study underscores the need for further clinical research to fully harness its therapeutic implications. Ultimately, this review aims to consolidate current knowledge on PSMA3-AS1 in human cancers and encourage continued exploration into its utility in innovative diagnostic and therapeutic approaches. - Source: PubMed
Publication date: 2025/04/21
Niu YunxiaMeng JinyingXue ZhaoChen Zhi