Ask about this productRelated genes to: NOSIP antibody
- Gene:
- NOSIP NIH gene
- Name:
- nitric oxide synthase interacting protein
- Previous symbol:
- -
- Synonyms:
- CGI-25
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-06
- Date modifiied:
- 2016-10-24
Related products to: NOSIP antibody
Related articles to: NOSIP antibody
- Renal cell carcinoma (RCC) is a malignant tumor of the urinary system with a high incidence. Due to limited treatment options and poor prognosis, novel therapeutic strategies are urgently needed. Recent studies revealed that Nosip participates in cell growth regulation by activating endothelial nitric oxide synthase (eNOS) and mediating the ubiquitination of erythropoietin receptor, suggesting its potential role as an oncogene in RCC progression. - Source: PubMed
Publication date: 2026/03/27
Wang JiaoHuang ZhengYang DandanGao JunjieXu QingDai MengluXia JunMa JiaPan Xueshan - To assess CT-to-CT angiography (CT-CTA) times at primary stroke centers (PSCs) for patients eligible for mechanical thrombectomy (MT) in acute ischemic stroke and to identify causes of imaging delays. - Source: PubMed
Sarnecki TatyanaMancuso-Marcello MarcoNikola ChristosSpooner OliverBhogal Pervinder - This study aims to explore shared key genes between head and neck neoplasm (HNN) and aging. - Source: PubMed
Publication date: 2026/02/01
Sun ChenChen XinleiLi JinzhaoHu LirongShi RuiLi ChunhuiWang Canli - RNA-binding proteins (RBPs) are key regulators of cellular transcription and are associated with the occurrence and development of diseases. - Source: PubMed
Publication date: 2025/03/26
Mo Lin-JianLiang Hai-QiYu Zhen-YuanLiang Yao-WenGu Chuan-XinWei Qiu-JuHe Qi-HuanWei Fa-YeCheng Ji-WenMo Zeng-Nan - Blastocyst complementation can potentially generate a rodent model with humanized nasopharyngeal epithelium (NE) that supports sustained Epstein-Barr virus (EBV) infection, enabling comprehensive studies of EBV biology in nasopharyngeal carcinoma. However, during this process, the specific gene knockouts required to establish a developmental niche for NE remain unclear. We performed bioinformatics analyses and generated Foxa1 mutant mice to confirm that Foxa1 disruption could potentially create a developmental niche for NE. Subsequently, MYD88-inactivated human pluripotent stem cells (hPSCs) were constructed and complemented with Foxa1-deficient mouse blastocysts, with Nosip-deficient mouse blastocysts as a control. The chimerism of human cells in mouse embryos was evaluated from E8.5 to E12.5 using genomic DNA PCR and immunohistochemistry. Our bioinformatics analysis indicated that the expression patterns of Foxa1 in E8.5 to E16.5 mouse embryos underscore its critical role in NE development. The generated mice with Foxa1 disordered region mutations displayed morphological abnormality in NE, suggesting Foxa1-knockouts could potentially establish a developmental niche for NE. In chimeric assays, human cells integrated into 80.00% of Foxa1-deficient embryos, compared with the 4.17% in controls. Immunohistochemistry results revealed robust proliferation of human cells in Foxa1-deficient mouse embryos. However, chimeras from Foxa1-deficient mouse embryos did not survive beyond E10.5, hindering the evaluation of human cell integration in mouse NE. Foxa1 disruption in mouse embryos significantly enhances the integration of human cells in human-mouse interspecies chimeras, thereby facilitating the generation of endoderm-derived organs through blastocyst complementation. Overcoming chimeras' embryonic lethality is crucial for successfully generating humanized NE in Foxa1-deficient mouse embryos. - Source: PubMed
Publication date: 2024/12/21
Wang Li-NaJia Jun-ShuangYang Xing-LongWen Yue-TingLiu Jing-XianLi Deng-KeChen Xing-RuiWang Jia-HongLi Ji-KeHuang Zhong-XiYao Kai-Tai