Ask about this productRelated genes to: TLR6 antibody
- Gene:
- TLR6 NIH gene
- Name:
- toll like receptor 6
- Previous symbol:
- -
- Synonyms:
- CD286
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-01
- Date modifiied:
- 2016-10-05
Related products to: TLR6 antibody
Related articles to: TLR6 antibody
- Bacterial meningitis is a severe disease with a fatality rate of 5-50%. It is mainly caused by or , which can also cause simultaneous infections outside the central nervous system. Toll-like receptors (TLRs) have an important role in the innate immune system. The TLR2 subfamily comprises the four highly homologous members TLR1, TLR2, TLR6, and TLR10, which also have an important immunomodulatory role in infectious diseases. - Source: PubMed
Publication date: 2026/02/25
Teräsjärvi JohannaTenhu ElinaCruzeiro Manuel LeiteSavonius OkkoRugemalira EmilieHe QiushuiPelkonen Tuula - Although toll-like receptor 6 (TLR6) plays an important role in innate immunity and host antiviral responses, its impact on pegylated interferon-alpha (PegIFNα) treatment efficacy in chronic hepatitis B (CHB) remains unclear. We aimed to investigate whether genetic variations of TLR6 are associated with the response to PegIFNα treatment. This study included 945 HBeAg-positive CHB patients treated with PegIFNα for at least 48 weeks and followed for 24 weeks from two multicenter phase IV trials (Cohort 1, n = 238; Cohort 2, n = 707). Across the TLR6 gene, 13 tag-SNPs were selected. Furthermore, a polygenic score (PGS) was developed by incorporating the newly identified variant of TLR6 and two previously reported SNPs (CD55_rs28371597 and CXCR4_rs28367495). Both TLR6 tag-SNPs and PGS were tested their associations with treatment efficacy. Among the 13 tag-SNPs, TLR6_rs7696175 (C > T) was identified as the most significantly associated variant with HBsAg decline at week 72 in both cohorts. The T allele of TLR6_rs7696175 was significantly associated with greater HBsAg decline, especially higher rates of decline ≥ 1 log IU/mL and ≥ 2 log IU/mL at week 72 (Cohort 1 + 2: p ≤ 0.001 for all associations). Moreover, the PGS integrating TLR6_rs7696175 and two previously reported SNPs significantly improved prediction accuracy for HBsAg decline at week 72 (Cohort 1 + 2: p < 0.001 for all comparisons) and outperformed single SNPs. Overall, this study identifies TLR6_rs7696175 as a novel genetic biomarker and demonstrates the superiority of a compact PGS for predicting HBsAg decline in PegIFNα-treated CHB patients, facilitating personalized treatment for CHB. - Source: PubMed
Zeng WantingWang JialinLiang XingheHou JiaChen JianjunPan XinghuaZhou BingHou JinlinJiang De-Ke - Determining the expression levels of TLRs involved in innate and adaptive immunity in canine distemper infections would provide a significant advantage for controlling the disease. - Source: PubMed
Karaca Bekdik İlknurDaldaban FadimeArslan KorhanAkyüz BilalAslan Öznur - Dendritic cells (DCs) are central to the initiation of anti-tumour immunity, yet the direct effects of electrochemotherapy (ECT) on DC biology remain poorly defined. We investigated how varying electric field strengths (800, 1000, and 1300 V/cm) modulate murine DC viability, phenotype, Toll-like receptor (TLR) expression and functional responses in vitro. ECT induced predominantly necrotic cell death in a voltage-dependent manner, with higher voltages markedly reducing viability. Despite this decline, surviving DCs exposed to 1000 V/cm and 1300 V/cm upregulated MHC II and CD80, indicating activation of the remaining population. ECT also altered TLR expression, significantly increasing TLR6 and TLR9 while reducing TLR4, TLR7 and TLR8 levels. Functionally, ECT impaired DC cytokine responses to TLR4 and TLR7/8 stimulation but preserved or enhanced responsiveness to the TLR9 agonist CpG, suggesting selective disruption of downstream TLR pathways. Together, these findings demonstrate that ECT differentially shapes DC survival and function depending on electric field intensity, with low-voltage ECT better preserving DC competence and higher voltages inducing activation but impairing responsiveness. These data highlight opportunities to optimise ECT protocols and rationally combine ECT with immune adjuvants to enhance therapeutic immunogenicity. - Source: PubMed
Publication date: 2026/02/26
Bendix Maura BBaker Kevin JForde Patrick FHouston AileenBrint Elizabeth - Tuberculosis (TB) is an international public health problem that results in preventable deaths each year. About 10% of those infected develop tuberculosis, indicating that host defense factors play a significant role in the progression to active disease. Polymorphic variants in the genes determine genetic diversity among populations. Many studies have revealed that single nucleotide polymorphisms (SNPs) in the genes coding for the innate immune molecules can affect the susceptibility and outcome of various diseases. Till date, Jammu & Kashmir state has largely remained unexplored in terms of genetic diversity. Toll-like receptors (TLRs) are fundamental elements of the innate immune system. TLRs identify microbial components that are conserved in pathogens and start the necessary inflammatory immune responses required for activation of adaptive immunity. Studies among populations with polymorphisms in TLR signaling genes can elucidate the connection between TLRs and human diseases. The present study is designed to find out the association of SNPs in and genes with pulmonary tuberculosis within the Dogra population of Jammu and Kashmir. This is conducted as a case-control study that includes 150 pulmonary tuberculosis (PTB) and 130 Healthy controls. SNP Genotyping for exploring the polymorphisms is done by using Sanger sequencing. T allele in (rs5743810) showed a protective role in TB infection ( = 0.0011, OR 0.16 95% CI 0.055-0.48). However, the data showed no significant association of (rs4833095) rs3804099 and rs4986790) with PTB in the Dogra population of Jammu region. Our data gave new insights into the role of TLR6 in defense and showed that TLR6 variant rs5743810 is associated with protection against TB in Dogra population of Jammu region. More studies on the larger ethnically diverse patient cohorts may help to validate the possible effect of these polymorphisms on the susceptibility to pulmonary TB. - Source: PubMed
Publication date: 2025/01/04
Sharma SakshiPriya InduSharma IsarGupta SuruchiGupta RahulMahajan RituKapoor Nisha