Ask about this productRelated genes to: HSPH1 antibody
- Gene:
- HSPH1 NIH gene
- Name:
- heat shock protein family H (Hsp110) member 1
- Previous symbol:
- -
- Synonyms:
- HSP105B, KIAA0201, HSP105A, NY-CO-25
- Chromosome:
- 13q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-19
- Date modifiied:
- 2015-11-19
Related products to: HSPH1 antibody
Related articles to: HSPH1 antibody
- Methylmercury (MeHg) is a well-recognized environmental neurotoxicant with a marked impact on neurodevelopment. However, studies integrating stage-specific transcriptomic responses in human neuronal development remain limited. - Source: PubMed
Publication date: 2026/06/09
Gomez-Caballero DannaOlivero-Verbel Jesus - Polyhexamethylene guanidine phosphate (PHMG-p), a cationic disinfectant previously used in humidifiers, has been linked to severe pulmonary diseases in Korea. This study aimed to elucidate the molecular mechanisms underlying PHMG-p-induced lung toxicity using an integrated multi-omics approach. BALB/c mice were intratracheally instilled with PHMG-p (0, 0.03, 0.1 mg/kg, twice weekly for 4 weeks). Histopathology revealed dose-dependent pulmonary lesions, including inflammatory infiltration, alveolar wall hyperplasia, and fibrosis. Transcriptomic profiling identified 213 and 1,506 differentially expressed genes (DEGs) in the low- and high-dose groups, respectively, with enriched pathways related to immune activation, cytokine signaling, and cellular stress responses. Proteomic analysis detected 148 and 1,168 differentially expressed proteins (DEPs), many of which overlapped with DEGs and were associated with chemokine signaling, protein refolding, and ion transport dysregulation. Metabolomic profiling of serum samples identified dose-responsive alterations in amino acid and energy metabolism, with notable increases in glutamate, leucine, serine, and related metabolites. Integrated omics analysis revealed consistent up-regulation of CDKN1A, HSP90AA1, HSPA1A, HSPA8, and HSPH1, and down-regulation of FPR1, suggesting their roles as potential biomarkers of PHMG-p-induced pulmonary injury. Pathway convergence indicated activation of inflammatory and fibrotic remodeling processes, as well as metabolic reprogramming involving glutamate and branched-chain amino acid pathways. These findings provide mechanistic insight into PHMG-p-induced lung toxicity and highlight multi-omics signatures that may serve as biomarkers for monitoring or predicting pulmonary damage caused by cationic polymer biocides. - Source: PubMed
Publication date: 2026/06/08
Lee Jung DaeKim Hyang YeonIm Jueng-EunLee HandulePark JuyoungPark KwangsikKang KeunsooJeong Hye GwangChae SehyunHwang DaeheeHan Beom SeokCho Wan-SeobKim SuhkmannKim Kyu-Bong - Heat stress (HS) is among the most economically consequential environmental challenges to global dairy production, causing progressive declines in milk yield, compositional quality, and mammary cellular integrity. The temperature-humidity index (THI) is the primary thermal load metric, with performance-impairment thresholds typically beginning at THI 68 in Holstein cattle, with severe impacts manifesting beyond THI 72; breed-specific thresholds for Jersey, Brown Swiss, and Simmental cows differ owing to their lower metabolic heat load and greater inherent thermotolerance. At the molecular level, HS activates heat shock protein networks-notably , , and -through / transcriptional activation, while simultaneously suppressing casein genes (, , ), lipogenic genes (, , ), amino acid transporters (, ), and mTOR-AKT-STAT5 translational machinery, collectively impairing milk biosynthetic capacity. Pro-apoptotic signaling (, upregulation; downregulation) and mitochondrial dysfunction further compromise mammary epithelial viability. Post-transcriptional regulation through miRNA, circRNA, and lncRNA competing endogenous RNA networks, alongside epitranscriptomic m6A modifications, adds further regulatory complexity. Genome-wide association studies have identified SNPs in , , , and as thermotolerance candidates compatible with sustained milk production. Nutritional supplementation with methionine, arginine, and taurine partially restores cellular synthetic capacity. Integrating multi-trait genomic selection with introgression, precision cooling, and targeted nutrition offers the most viable path toward climate-resilient, high-producing dairy cattle. - Source: PubMed
Publication date: 2026/05/21
Ma QingshanTharwat MohamedAlshanbari Fahad AKhan Muhammad Zahoor - Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with poor prognosis, often evolving from Barrett's esophagus (BE). Understanding the molecular mechanisms driving this progression is critical for identifying diagnostic biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/05/10
Tao LulongGuo YantingLu FangQi ChangyongZhang GuoxinYan Jin - -Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system and is involved in the development of neural tissue as well as the regulation of its functions. Meanwhile, GABA has also been demonstrated to confer multiple physiological benefits, including alleviating stress and improving metabolic homeostasis. This study investigated GABA effects on proliferation, differentiation, and temperature stress protection of bovine skeletal muscle satellite cells (BSCs). - Source: PubMed
Publication date: 2026/04/14
Manzoor AbidNaseem SajidaFu ZhiqiRuan ChaohuiLiu XuYan ChunriChoi SeonghoLi Xiangzi