Ask about this productRelated genes to: NSUN2 antibody
- Gene:
- NSUN2 NIH gene
- Name:
- NOP2/Sun RNA methyltransferase 2
- Previous symbol:
- MRT5
- Synonyms:
- FLJ20303, TRM4, Misu
- Chromosome:
- 5p15.31
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-25
- Date modifiied:
- 2019-02-26
Related products to: NSUN2 antibody
Related articles to: NSUN2 antibody
- Renal fibrosis (RFib) is a final common pathway in chronic kidney disease (CKD) progression. Although 5-methylcytosine (m5C) RNA modification can regulate mRNA fate, its role in RFib and redox-regulated cell death remains incompletely defined. - Source: PubMed
Publication date: 2026/04/21
Zan YuxinChen LinMa LimingMeng PanpanMa ShinanLiu HuizhongTian YaqiHe XijuWang ZhixiaoDing Yan - Despite advances in immunotherapy, significant challenges remain in the treatment of esophageal cancer (EC), largely due to its molecular complexity and the immunosuppressive tumor microenvironment (TME). Recently, long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor immunity, influencing key pathways involved in inflammation, immune evasion, and therapeutic response. In this review, we examine the role of immune-related lncRNAs in modulating major immunological signaling pathways in EC, including Programmed Cell Death Protein 1/Programmed Death-Ligand 1 (PD-1/PD-L1), Toll-Like Receptor (TLR), Tumor Necrosis Factor-alpha (TNF-α), Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathways. Oncogenic lncRNAs such as LINC02096, Cancer Susceptibility Candidate 9 (CASC9), and Small Nucleolar RNA Host Gene 20 (SNHG20) promote immune checkpoint expression, facilitating immune escape and resistance to checkpoint blockade. Other lncRNAs, including LINC02820, NSUN2-methylated lncRNA (NMR), and Myeloid-Associated Long Non-coding RNA (MALR), activate TNF-α/NF-κB signaling, contributing to inflammation-driven metastasis. Additionally, MALAT1 and FAM83H-AS1 regulate transforming growth factor-beta (TGF-β)-mediated epithelial-to-mesenchymal transition, enhancing tumor progression. Conversely, NF-κB Interacting Long Non-coding RNA (NKILA) functions as a tumor suppressor by inhibiting NF-κB activation. Importantly, lncRNA expression profiles correlate with immune checkpoint levels, immune cell infiltration, and patient survival, highlighting their potential as biomarkers for prognosis and therapeutic response. This review provides a framework for understanding lncRNA-mediated immune regulation and supports their translational potential in EC immunotherapy. - Source: PubMed
Publication date: 2026/04/17
Uttam VivekRana Manjit KaurSethi GautamJain Aklank - Chronic kidney disease (CKD) is increasing globally, presenting a critical health challenge. Renal fibrosis, the main pathological feature of CKD, is poorly understood and lacks targeted therapies. Here, we reveal that 5-methylcytosine (m5C) RNA methylation, primarily mediated by methyltransferase NSUN2, is significantly upregulated in renal fibrosis. Reduction of m5C RNA methylation levels upon NSUN2 loss attenuates fibrosis responses in cells, and specific knockout of NSUN2 in renal tubular epithelial cells alleviates renal fibrosis in several disease models. Mechanistically, NSUN2 methylates and stabilizes glycine amidinetransferase (GATM) mRNA. GATM exacerbates mitochondrial fission not only by directly binding to Drp1 but also through its product creatine, collectively driving the progression of renal fibrosis. We subsequently identify an inhibitor of NSUN2 that mitigates the progression of renal fibrosis. Collectively, our study demonstrates that targeting NSUN2-mediated m5C methylation of GATM mRNA therapeutically offers a promising strategy to slow the progression of CKD. - Source: PubMed
Publication date: 2026/04/16
Suo XiaoguoZhang MengmengZhu QiLuo QichaoWang FangGe QinglinPeng LijinYu JutaoWei JieHou ChaoJi MingluZhang DanfengWu LinhuiWang ZhijuanLi ChaoChen XinZhu SaiXie ShuaishuaiDong Yu-HangChen PengYang ChenJin JuanChen FeiXavierWang JiananMeng Xiaoming - TFEB acts as a master transcriptional regulator of lysosomal activity, which is central to host antiviral defense. Multiple viruses target TFEB to evade lysosomal degradation in host cells. This study investigated how HBV suppresses TFEB via NSUN2-mediated mC RNA modification. - Source: PubMed
Publication date: 2026/04/11
Dong XuejiaoDing ShuangHe LiliLuo FuyuCui ZhangboTang ShiZhan GuanliHao HaojieGuan WuxiangShi Chunwei - Prostate cancer is the most common malignant tumor among men worldwide, severely threatening the health of aging males. RNA 5-methylcytosine (m5C) modification has been demonstrated to play a significant role in the initiation and progression of various tumors. However, the role of ALYREF, a key methyl-recognizing protein for m5c modification, is still unclear in prostate cancer. In our study, we found that knockdown of ALYREF reduces the proliferation, invasion and metastasis of prostate cancer. ALYREF promotes anoikis resistance in prostate cancer by positively regulating BPIP3 and thereby activating autophagy. Mechanistically, we found that ALYREF is a methylation recognition protein that directly and specifically recognizes the m5c site of BNIP3 mRNA and enhances the stability of BNIP3 mRNA, which activates autophagy in prostate cancer cells, and thus enhances the anoikis resistance and metastatic ability of cancer cells. Overall, our study revealed the important role of ALYREF-mediated m5C methylation modification in the mechanisms of autophagy and anoikis resistance in prostate cancer, providing an important molecular target for the treatment of advanced prostate cancer. - Source: PubMed
Publication date: 2026/04/07
Sun GuangyuChen ShuaiqiChen MingzheXiao XiongZhang RuoxuanYe HaoGuo YuxuanLiu Ranlu