Ask about this productRelated genes to: PARP6 antibody
- Gene:
- PARP6 NIH gene
- Name:
- poly(ADP-ribose) polymerase family member 6
- Previous symbol:
- -
- Synonyms:
- pART17
- Chromosome:
- 15q23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-25
- Date modifiied:
- 2016-10-05
Related products to: PARP6 antibody
Related articles to: PARP6 antibody
- In this study, we report the design, synthesis, and biological evaluation of a new series of triterpenoid metronidazole-linked 1H-1,2,3-triazole conjugates (16-23) as potential targeted therapies. These compounds were screened across a panel of ovarian cancer cell lines. The cytotoxic profiles of all β-AKBA and β-ABA metronidazole-triazole hybrids were evaluated against normal endothelial cells (HUVEC), cisplatin-sensitive ovarian cancer cells (A2780-S), and cisplatin-resistant cells (A2780-CP). Several derivatives showed enhanced cytotoxicity relative to their parent triterpenoids, with compound 21 exhibiting the most favourable selectivity index (SI ≈ 1.61), demonstrating preferential toxicity toward malignant cells while sparing normal cells. The selective cytotoxicity is controlled by reaching an ideal balance of molecular weight, topological polar surface area, hydrogen-bonding characteristics, and nitrogen-rich substituents, according to structure-activity relationship (SAR) studies. Computational docking studies further confirmed that compound 21 displays strong complementarity and robust binding affinity toward PARP6, suggesting a possible mechanism of action through PARP6 modulation. The study provides a promising platform for advancing triterpenoid-based targeted therapeutics in ovarian cancer therapy. - Source: PubMed
Publication date: 2026/02/05
Khan Sadiq NoorFarhadi SamiraRehman Najeeb UrHalim Sobia AhsanAl-Amri Issa SKhan AjmalAnwar Muhammad UCsuk RenéAvula Satya KumarAl-Harrasi Ahmed - ADP-ribosyl-transferases (ARTs) are versatile post-translational regulators. Mammalian ARTs include poly- and mono-ADP-ribosylating enzymes, which transfer ADP-ribose molecules deriving from β-NAD+ to their targets. Mono-ADP-ribosylation (MARylation), which is catalyzed by mono-ARTs such as PARP3, PARP6-PARP12 and PARP14-PARP16, tunes the activity of targets involved in fundamental cell processes and various signaling pathways, ranging from those regulating cell survival and proliferation to those modulating the cellular response to stress and viral infection. Recent advancements of techniques that enable the discovery of MARylation targets across cellular compartments have further expanded our knowledge about the physiological roles of these targets and the potential connection between MARylation and the onset of pathologies. Furthermore, increasing efforts in the development of specific drugs targeting the different MARylating PARP proteins are opening avenues for innovative pharmacological treatments. In this Review, we illustrate the cell cycle progression, intracellular membrane trafficking and cellular stress pathways regulated by mono-ART PARP proteins. We then describe what is known about the roles of MARylating PARP proteins in the context of viral infection and cancer. Finally, we discuss potential future directions towards mapping out the complex network of PARP targets and functions. - Source: PubMed
Publication date: 2025/07/31
Di Paola SimoneGrimaldi GiovannaCorda Daniela - This study aimed to investigate the correlation between chromosomal abnormalities in spontaneous abortion with clinical features and seek copy number variations (CNVs) and genes that might be connected to spontaneous abortion. - Source: PubMed
Publication date: 2024/04/26
Qin YuTouch KoksearSha MenghanSun YananZhang ShunranWu JianliWu YuanyuanFeng LingChen SuhuaXiao Juan - Ferroptosis is the oxidative death of cells attributed to an imbalance in intracellular lipid reactive oxygen species metabolism, a reduction in cell antioxidant capacity, and an accumulation of membrane lipid peroxides. Trophoblast cells are a group of cells susceptible to ferroptosis. The ferroptosis of trophoblast cells has a major effect on the development of preeclampsia (PE), although the impact of ferroptosis-related genes (FRGs) on PE has not been well characterized. This study obtained PE-related information from the Gene Expression Omnibus database and FRGs from the FerrDb ferroptosis database. Seventeen PE-related differentially expressed ferroptosis-related genes (DE-FRGs) that were closely associated with cellular regulation and immune response were obtained. According to the results of a subsequent functional enrichment analysis, it was found that the above marker genes may impact PE by regulating immune response, amino acid metabolism, the cell cycle, and multiple pathways correlated with PE pathogenesis. Subsequently, we used LASSO and support vector machine recursive feature elimination algorithms to help identify GOT1, CFL1, FZD7, VDR, PARP6, TMSB4X, VCP, and ENO3 as marker genes from the 17 obtained genes. According to the results of single-sample gene set enrichment analysis (ssGSEA), the immune microenvironment of PE changed, possibly due to the GOT1 and TMSB4X genes. Furthermore, 23 drugs targeting one marker gene were determined. A constructed ceRNA network revealed a complicated regulatory link based on the eight marker genes. In this study, diagnostic potency was developed, and insight into the mechanism of PE was provided. In-depth research should be conducted before clinical application to evaluate the diagnostic value of DE-FRGs in PE. - Source: PubMed
Publication date: 2023/07/20
Wang QingminXiong ZhihuiWang BaimiaoWang WeiZheng Huiling - Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in a series of cancer pathogenesis processes, and is considered a promising therapeutic target for cancer treatment. However, a comprehensive analysis of NAD+ metabolism events on immune regulation and cancer survival has not yet been conducted. Here, we constructed a prognostic NAD+ metabolism-related gene signature (NMRGS) associated with immune checkpoint inhibitor (ICI) efficacy in glioma. - Source: PubMed
Publication date: 2023/02/08
Jiang ChengZhou YujieYan LizhaoZheng JianglinWang XuanLi JunjunJiang Xiaobing