Ask about this productRelated genes to: MORC3 antibody
- Gene:
- MORC3 NIH gene
- Name:
- MORC family CW-type zinc finger 3
- Previous symbol:
- ZCWCC3
- Synonyms:
- ZCW5, NXP2, KIAA0136
- Chromosome:
- 21q22.12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-24
- Date modifiied:
- 2016-10-05
Related products to: MORC3 antibody
Related articles to: MORC3 antibody
- Cuproptosis, a newly discovered form of copper-driven regulated cell death, has been shown to be closely related to ovarian function. However, whether the oocyte dysfunction, decreased ovulation efficiency, and cumulus cell aging caused by copper overload or imbalance are associated with regulatory pathways related to cuproptosis remains unclear. In this study, the expression profiles of genes related to cuproptosis in cumulus cells were comprehensively analyzed through transcriptome sequencing and metabolome analysis, and key genes and pathways that affect oocyte maturation were identified in response to elesclomol and CuSO treatment. Transcriptome analysis of cumulus cells revealed the differential expression of genes involved in key biological processes, such as cellular senescence (AKT3, MORC3, RBL1, etc.), gap junctions (GJA1, GNAI1, GJB3, etc.), steroid biosynthesis (FDX1, HSD17B7, CYP1A1, etc.), and cell cycle regulation (CDK2, CCNB2, MAPK7, etc.). Metabolomic analysis revealed significant changes in the levels of malic acid, PS (18:3(10,12,15)-OH(9)/14:0), and PA (21:0/LTE4), among other compounds. Subsequent Smart-seq analysis of oocytes revealed that after cuproptosis was induced in cumulus cells, oocyte maturation was disrupted, which affected genes associated with cellular senescence (TGFB2, SIRT1, CHEK2, etc.), oocyte meiosis (FBXO5, CCNB3, PLK1, etc.), and DNA methylation (PPM1D, DNMT3B, KMT2A, etc.). These findings provide deeper theoretical support for the key genes and biological processes involved in cumulus cell regulation and oocyte maturation, further clarifying the regulatory mechanisms of cuproptosis in the field of reproduction. - Source: PubMed
Publication date: 2026/05/05
Xu HongTian TianXu DanDu XiaoxueSu RuiLiang JinghongLiu YingZhang YuqingLiu ChangLiang ShuangLi QingyingDing DeliHan YongshengZhai BoLi JidongChen ChengzhenZhang JiabaoJiang HaoYuan Bao - Endogenous retroviruses (ERVs) compromise genome integrity when expressed, and cells have evolved chromatin-based pathways to silence their transcription. The histone H3.3 chaperone DAXX localizes to a subset of ERVs and enforces their silencing through incompletely defined mechanisms. Using complementary biochemical and genetic approaches, we identify a conserved basic patch within the DAXX histone-binding domain that engages DNA, promotes H3.3 nucleosome assembly in vitro, and is required for H3.3 enrichment at DAXX-bound ERVs in cells. Despite failure to deposit H3.3, DAXX with substitutions in this basic patch retains localization to ERVs and preserves silencing, indicating that histone H3.3 is dispensable for DAXX-mediated repression of ERVs. By contrast, ERV silencing requires the DAXX C-terminal SUMO-interacting motif, which mediates recruitment of SUMOylated repressors, including MORC3. These findings define modular outputs downstream of DAXX recruitment that uncouple nucleosome assembly from ERV silencing and highlight SUMO-dependent effector recruitment as the primary mechanism of silencing. - Source: PubMed
Publication date: 2026/03/23
Jain Aayushi YHoelper DominicRashoff Andrew QLewis Peter W - Saibaba J, Chandra N, Amalnath D, "The Cancer that Carried the Chalk"-NXP2+ Paraneoplastic Dermatomyositis Unleashing Calcinosis Cutis and Peripheral Neuropathy. J Assoc Physicians India 2026;74(2):102-103. - Source: PubMed
Saibaba JayaramChandra NidhishAmalnath DeepakSubrahmanyam Dks - In patients with dermatomyositis (DM) and anti-nuclear matrix protein 2 autoantibodies, associations with both cancer and calcinosis are well established. However, the relationship between the progression of calcinosis and the development of cancer remains unknown. Herein, we describe a unique case that prompts hypotheses regarding shared immunologic mechanisms underlying these clinical complications. - Source: PubMed
Mecoli Christopher AViswanathan Akila NRosen AntonyCasciola-Rosen Livia - Idiopathic inflammatory myopathies (IIMs) are a group of systemic disorders characterized by chronic autoimmune dysregulation; their hallmark is symmetric proximal muscle weakness, often with characteristic cutaneous eruptions in dermatomyositis subtypes. Anti-nuclear matrix protein-2 (NXP-2) antibodies are classified as myositis-specific autoantibodies, yet their prevalence remains persistently low. Adult dermatomyositis associated with NXP-2 positivity exhibits a distinctive phenotype in terms of clinical manifestations, complications, and prognosis-particularly an elevated malignancy risk-and is now regarded as an independent subset within the IIMs spectrum. However, reported frequencies vary widely across cohorts, and cases complicated by rhabdomyolysis are exceedingly rare, posing major challenges to timely recognition and optimal management. - Source: PubMed
Publication date: 2026/02/04
Zhang ZhengyiJiang DaweiWei TaoLong Kunlan