Ask about this productRelated genes to: GAPVD1 antibody
- Gene:
- GAPVD1 NIH gene
- Name:
- GTPase activating protein and VPS9 domains 1
- Previous symbol:
- -
- Synonyms:
- DKFZP434C212, KIAA1521
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-22
- Date modifiied:
- 2016-10-05
Related products to: GAPVD1 antibody
Related articles to: GAPVD1 antibody
- Gastric cancer (GC) is a malignant gastrointestinal tumor that originates from the epithelium of the gastric mucosa, and circular RNA (circRNA) plays an important role in its progression. - Source: PubMed
Publication date: 2025/06/20
Zhu LinqiYao ZhendongLiu YunShao ShiheZhou WeiDing JiaweiMao BonengShao ChenCui Feilun - Mitral valve prolapse (MVP), the most prevalent primary valvular disease, serves as a direct risk factor for multiple cardiovascular disorders and exhibits a high prevalence in the general population. As no specific pharmacological therapies currently exist for MVP, the identification of precise therapeutic targets is imperative. - Source: PubMed
Publication date: 2025/04/30
Chen BohangWang ChuqiaoLi Wenjie - Triple-Negative Breast Cancer (TNBC) accounts for 15-20% of all breast cancers and approximately 50% of breast cancer deaths. Chemotherapy remains the mainstay of systemic treatment due to the lack of effective therapy targets. Thus, more studies are urgently needed to identify new therapeutic targets in TNBC patients. - Source: PubMed
Wang LuZhang LifenLuo PeiXia ZeyuShao ShanNing QianGu ShanzhiZhao XinhanLuo Minna - Triple-negative breast cancer (TNBC) has long been considered a major clinical challenge due to its aggressive behavior and poor prognosis. Cancer stem cells (CSCs) are known as the main cells responsible for tumor origination, progression, recurrence and metastasis. Here, we report that M2-type tumor-associated macrophages (TAMs) contribute to cancer stemness in TNBC cells via the secretion of VEGFA. Reciprocally, elevated VEGFA expression by TAM-educated TNBC cells acts as a regulator of macrophage polarization, therefore constitute a feed-back loop between TNBC cells and TAMs. Mechanistically, VEGFA facilitates the CSC phenotype via the NRP-1 receptor and downstream GAPVD1/Wnt/β-catenin signaling pathway in TNBC cells. Our study underscores the crosstalk between TNBC cells and TAMs mediated by VEGFA and further clarifies the role and underlying mechanisms of the VEGFA/NRP-1/GAPVD1 axis in regulating cancer stemness. We also document an immunosuppressive function of VEGFA in the tumor microenvironment (TME). Therefore, the present study indicates crosstalk between TNBC cells and TAMs induced by VEGFA and provides a potential implication for the combination of immunotherapy and VEGFA-targeted agents in TNBC therapy. - Source: PubMed
Publication date: 2024/01/01
Wang LuZhang LifenZhao LinShao ShanNing QianJing XinZhang YujiaoZhao FengyuLiu XizhiGu ShanzhiZhao XinhanLuo Minna - Cord blood (CB) CD34+ cells have the potential to be used to achieve artificial hematopoiesis because of their ability to expand and differentiate in multiple directions. However, the mechanism and molecular changes underlying such differentiation are still unclear. The differentiation of CB CD34+ cells is generally driven by subtle changes in gene expression. A crucial method for examining gene expression is quantitative real-time polymerase chain reaction, but the accuracy of the results is dependent on the use of reliable reference genes. Here, the transcription levels of 10 novel candidate reference genes (, , , , , , , , , and ) and 8 traditional reference genes (, , , , , , , ) in CB CD34+ cells under different oxygen concentrations were screened and evaluated by using the geNorm and NormFinder algorithms. Comprehensive analysis conducted by RefFinder online tool showed that (a traditional reference gene) and (a novel reference gene) had the most stable expression, whereas and were the least suitable reference genes under these conditions. These results may serve as a basis for selecting reference genes with stable expression for more accurate normalization under different oxygen concentration stimulation during CB CD34+ cells differentiation. - Source: PubMed
Publication date: 2023/11/23
Xiao JunLi ZhicaiLi XiaoweiLei HuifenMeng FangyuanLi Cuiying