Ask about this productRelated genes to: GMPS antibody
- Gene:
- GMPS NIH gene
- Name:
- guanine monophosphate synthase
- Previous symbol:
- -
- Synonyms:
- GATD7
- Chromosome:
- 3q25.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-22
- Date modifiied:
- 2017-03-16
Related products to: GMPS antibody
Related articles to: GMPS antibody
- Mutations in the RAS gene family (NRAS, KRAS) are critical drivers of late-stage acute myeloid leukemia (AML) progression. They are frequently detected in relapsed/refractory AML and AML transformed from myelodysplastic syndrome (MDS). Occurring as late-stage genetic events, RAS mutations synergize with early drivers to promote leukemogenesis. While mutually exclusive with FLT3-ITD mutations, they coexist with KIT, RUNX1, CEBPA mutations and MLL rearrangements. Granulocyte-monocyte progenitors (GMPs) serve as the cellular origin for RAS-mutant leukemia stem cells (LSCs). Ultimately, RAS mutations drive monocytic differentiation of LSCs and venetoclax (VEN) resistance through BCL-2 family rewiring. Beyond AML, they are hallmark genetic lesions in juvenile myelomonocytic leukemia (JMML) and present in 15%-20% of pediatric acute lymphoblastic leukemia (ALL) cases. Here, we propose a comprehensive pathogenic model and targeted therapeutic framework focusing on RAS, MCL-1, BCL2L1 to overcome drug resistance and improve patient outcomes. - Source: PubMed
Publication date: 2026/04/11
Jiang CongfaWang HangxuanZhao JiaxinXu YuweiDuan Shiwei - Aquatic product spoilage primarily results from specific spoilage organisms (SSOs) such as Pseudomonas, Aeromonas, and Shewanella, with biofilm formation playing a pivotal role in accelerating deterioration. The bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) orchestrates this process by regulating biofilm assembly. Intracellular c-di-GMP levels, modulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), dictate bacterial behavior: higher concentrations suppress motility, promote adhesion, and trigger extracellular polymeric substance (EPS) secretion, reinforcing biofilm integrity. This protective matrix enhances SSO resistance to refrigeration, antimicrobial agents, and environmental stressors. Within biofilms, SSOs display heightened metabolic activity, producing proteases and lipases that degrade proteins and lipids, yielding spoilage metabolites such as trimethylamine, hydrogen sulfide, and organic acids-compounds responsible for off-odors, texture deterioration, and quality loss. Interventions targeting c-di-GMP signaling, such as DGC/PDE inhibitors, quorum-sensing disruption, and combined physical-chemical treatments, may effectively suppress biofilm formation and prolong shelf life. Further studies should elucidate c-di-GMP's interactions with other regulatory networks and its influence on multispecies biofilm dynamics in aquatic products. This review examines biofilm formation and its role in aquatic product spoilage, along with c-di-GMP's regulatory function in spoilage-associated biofilms and its broader spoilage implications, offering a theoretical foundation for further research on c-di-GMP-mediated interactions in multispecies biofilm systems. - Source: PubMed
Yang JunyiXie Jing - The (LCG) is a dual-purpose breed of major economic importance in China, valued for its high cashmere yield and meat quality. Cashmere fineness (CF) remains a primary target for genetic improvement because fiber diameter directly determines textile value and market price. This study examined the sex-specific effects of single-nucleotide polymorphisms in the () and () genes on CF and a broad spectrum of production traits to identify functional markers for marker-assisted selection. - Source: PubMed
Publication date: 2026/03/15
Yuan QingyuZhan QiyingDuan RanZhao YichaoLin HaoLi ShuaitongHong WeihangMa HuaKong LingchaoLi WangshuWang HaoranKou XiaochenLyu DakunGuo YunlongLiang JiameiWang Zeying - Accumulating evidence shows that excess cholesterol and glucose uptake stimulates the expansion of hematopoietic stem/progenitor cells and myeloid progenitors, resulting in increased production of inflammatory cells and atherosclerotic progression. However, the role of other metabolites in plaque progression remains unclear. Hereby, we observed elevated α-ketoglutarate levels in granulocyte-monocyte progenitors (GMPs) of Ldlr mice on a high-fat diet (HFD), determined by targeted metabolomics. On top of HFD, α-ketoglutarate administration further increased GMP proportion, myeloid cell production, and plaque progression in Ldlr mice. The regulation of α-ketoglutarate in atherosclerosis required the expression of its receptor, oxoglutarate receptor 1 (OXGR1), in bone marrow cells (BMCs), as transplantation of OXGR1 BMCs attenuated plaque progression compared to transplantation of OXGR1 BMCs in HFD-fed Ldlr recipients. Using targeted metabolomics, single-cell RNA sequencing and validation experiments, we demonstrated that the α-ketoglutarate/OXGR1 axis upregulated the expression of purine nucleoside phosphorylase (PNP) in GMPs, which promoted de novo purine biosynthesis and reduced the levels of nicotinamide mononucleotide and nicotinamide adenine dinucleotide (NAD), thereby disturbing mitochondrial homeostasis and increasing the production of myeloid cells. Furthermore, proteomics data revealed that PNP treatment regulated the redox status by increasing the expression of NAD kinase (NADK), thereby accelerating NAD consumption. Additionally, PNP promoted the transcriptional activation of NF-κB via ubiquitin, enhancing ROS production and inflammation in lineage cells. Spearman's correlation analysis revealed a positive association between isocitrate and low-density lipoprotein cholesterol levels in human plasma. Overall, HFD potentiated α-ketoglutarate, contributing to atherosclerosis. - Source: PubMed
Publication date: 2026/03/27
Zhao JiweiSu LiLi WenhaoLam Sin ManYan CenZhou TaotaoDeng YalanDong YuanZhou YuanShui GuanghouFeng Yingmei - The use of cannabis in medicine has rich historical roots spanning thousands of years before stigmatism surrounding the narcotic use of this plant led to strict regulations on its use. Recently, medicinal and recreational cannabis use has experienced a resurgence in many regions of the world, receiving attention from society and policy as legalization increases availability and necessity of greater mindfulness. Research on cannabis is gaining more traction to better inform the regulations needed to ensure the safe and effective usage of this drug. Owing to cannabis being a natural plant product, there are contamination risks even when it is produced under good manufacturing practices (GMPs), which can pose a health risk to consumers. Several pathogenic bacteria and fungi have been found on cannabis, either causing disease in the plant or causing health issues in people who consume the product. The literature on the microbiological safety of cannabis focuses on identifying the species that exist on the plant and the efficacy of sanitation methods currently used in the food industry for the decontamination of cannabis. Specifically, irradiation methods such as gamma irradiation and electron beams have been applied to effectively lower the microbial load on cannabis. However, these irradiation methods face pushbacks due to cost barriers, regulatory issues, and customer disapproval for irradiated products. Innovative gaseous and non-thermal plasma methods are beginning to gain attention because of their preliminary results in effectively decontaminating food products. Indirect non-thermal plasma methods such as ozone and plasma-processed air present new, possibly better, sanitation options for the complex flower structure of cannabis while maintaining its quality. This review discusses the historical importance of cannabis usage and the need to mitigate microbial contamination while considering the current methods used to sanitize cannabis. Finally, we present innovative gaseous and non-thermal plasma methods that are currently being integrated or are under research for cannabis sanitization to improve the safety and future regulatory aspects of cannabis processing. - Source: PubMed
Publication date: 2026/03/12
Nestel SamanthaHedtfeld ClaasSpilker UlrikeEhlbeck JörgGuenther SebastianSchnabel Uta