Ask about this productRelated genes to: NUP62 antibody
- Gene:
- NUP62 NIH gene
- Name:
- nucleoporin 62
- Previous symbol:
- -
- Synonyms:
- p62, DKFZp547L134, IBSN, SNDI, MGC841, FLJ20822, FLJ43869
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-06
- Date modifiied:
- 2016-06-01
Related products to: NUP62 antibody
Related articles to: NUP62 antibody
- Identification of drug resistance drivers of breast cancer (BC) is a multifaceted challenge. Here, we demonstrated that NUP62 is significantly upregulated in BC tissues and cell lines, and its high expression correlates with a poor prognosis. Functional experiments revealed that NUP62 promotes BC cell proliferation, migration, and malignant phenotypes, while inhibiting ferroptosis. Mechanistically, NUP62 competitively binds to KEAP1, disrupting KEAP1-mediated ubiquitination and degradation of NRF2. This stabilization promotes NRF2 nuclear translocation, enhancing the transcription of antioxidant genes and inhibiting ferroptosis. Crucially, eribulin-identified through virtual screening of FDA-approved compounds-selectively inhibited NUP62, destabilizing NRF2 and abrogating its nuclear localization. , eribulin or NUP62 silencing significantly suppressed tumor growth in xenograft models. Our findings establish the NUP62-KEAP1-NRF2 axis as a master regulator of ferroptosis in BC, positioning eribulin as a promising therapeutic agent for NUP62-high tumors. - Source: PubMed
Publication date: 2026/03/26
Qiu ZiranLin YuChen ShanzhengCao WenqingYang JunLi RuiChen YuanYao XiaoqingFu SenlinJin Na - Mesothelioma is an aggressive malignancy with limited therapeutic options. Genetic alterations involving the Hippo pathway are commonly observed. O-GlcNAcylation is frequently elevated in cancer and drives tumour progression. However, its relationship with Hippo pathway dysfunction in mesothelioma remains unclear. - Source: PubMed
Publication date: 2026/03/06
Mukai SatomiSato TatsuhiroKamei YasuhiroKato KagayakiMishiro-Sato EmiKondo-Ida LisaYabuta NorikazuHiroshima KenzoSekido Yoshitaka - Mei-P26, a member of the TRIM-NHL family, plays a pivotal role in Drosophila germline development, including female meiosis. However, its role in male meiosis remains unclear. We observed abnormal spermatid cysts comprising 16 cells in mei-P26 mutant testes, which resulted from spermatid differentiation in the absence of meiosis. The same phenotype was observed in the cysts derived from spermatocytes subjected to mei-P26 knockdown. No cysts undergoing meiosis were observed, and cyclin-dependent kinase 1 (Cdk1) was not activated in the knockdown spermatocytes. However, these phenotypes are unlikely to result from altered phosphorylation of Cdk1, which is necessary for its activation. Instead, aberrant subcellular localization of Cyclin B (CycB) was observed. In wild-type, CycB first migrates into the nucleus of spermatocytes at earlier stages, is then exported from the nucleus, and re-enters the nucleus just before meiosis. By contrast, in mei-P26 spermatocytes and mei-P26 knockdown cells, CycB remained accumulated in the nucleus before meiosis. Another M-phase Cyclin, Cyclin A also showed nuclear accumulation in mei-P26 knockdown spermatocytes. Interactions between CycB and the nuclear export factors Emb and Nup62 remained unchanged. Although mammalian PLK1 modifies nuclear export signal of CycB in mitosis, a Drosophila orthologue, Polo, is unlikely to be involved in this meiotic phenotype. The loss of mei-P26 resulted in continuous activation of the meiotic checkpoint, which retains M-phase cyclins within the nucleus until multiple conditions necessary for meiosis are satisfied, thereby preventing Cdk1 from full activation. Our findings will be useful for understanding the role of Mei-P26 in other developmental processes.Key words: meiosis, spermatogenesis, Drosophila, mei-P26, checkpoint, cyclins, Cdk1. - Source: PubMed
Publication date: 2026/03/10
Oda MaiTanaka YuriInoue Yoshihiro H - Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified. RNA sequencing was performed to identify transcriptional regulators and corresponding target genes. To explore the biological effects and underlying mechanisms of these regulators, a comprehensive methodology was utilized, encompassing chromatin immunoprecipitation, dual-luciferase reporter assay, qRT-PCR, western blot, alongside gene over-expression and silencing techniques, co-immunoprecipitation, and mass spectrometry. The MTT assay, soft agar colony formation, Matrigel invasion, and nude mouse xenograft models were applied to assess oncogenic properties. Patient survival was analyzed using the log-rank test. Armadillo repeat containing 12 (ARMC12) was identified as a MYC-interacting modulator within liquid condensates to up-regulate critical nucleoporin-encoding targets (//), which promoted nuclear pore complex (NPC) biogenesis to facilitate nuclear trafficking of oncogenic effectors, thereby enhancing invasion and metastasis of NB. As a protein within extracellular vesicles of colonizing NB tissues, MGL_0381 also facilitated MYC transactivation via physical interaction to accelerate NPC biogenesis and NB progression. Tioconazole (TCZ) and UU-T02 were identified as efficient inhibitors blocking ARMC12-MYC and MGL_0381-MYC interaction, and synergistically reduced NPC number and aggressive features of NB. High , , , , or levels served as markers of unfavorable patient outcomes in clinical cohorts. These findings collectively demonstrate that dual targeting of AMRC12 and disrupts MYC liquid condensates-driven NPC biogenesis during NB progression. - Source: PubMed
Publication date: 2026/01/01
Hu AnpeiYang ChunhuiWang ZhijieWang XiaolinLi XinyueZhou ShunchenZhao BosenQu JiayingWang XiaojingZheng LiduanTong Qiangsong - Breast cancer (BRCA) continues to be a major global health challenge around the world. Overcoming endocrine resistance remains one of the most significant challenges in the global fight against the disease. This study investigates the function of nucleoporin 62 (NUP62) in BRCA progression and evaluates its potential as a therapeutic target. - Source: PubMed
Publication date: 2026/01/07
Wang ZhihuaiGu LikaiYang MeiZhou YiPan HuiQin XihuXiong Chen