Ask about this productRelated genes to: LYK5 antibody
- Gene:
- STRADA NIH gene
- Name:
- STE20 related adaptor alpha
- Previous symbol:
- -
- Synonyms:
- NY-BR-96, LYK5, Stlk, STRAD
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-15
- Date modifiied:
- 2018-11-09
Related products to: LYK5 antibody
Related articles to: LYK5 antibody
- Ivermectin (IVM), a widely used antiparasitic, raises emerging concerns regarding reproductive toxicity. This study investigated the effects of clinically relevant IVM concentrations (20, 40, 60ng/mL) on endothelial cells from porcine corpus luteum, a translational model for vascular function. Proliferation and metabolic activity were assessed via BrdU ELISA and ATP bioluminescence assay, VEGF-A secretion by ELISA, redox status through superoxide and nitric oxide, FRAP assay, and SOD activity by colorimetric methods. IVM significantly impairs endothelial homeostasis by inhibiting proliferation (p<0.05) and suppressing VEGF-A production at higher doses (p<0.05), despite a compensatory increase in metabolic activity. IVM induced a biphasic nitric oxide effect (p<0.01) and elevated superoxide levels (p<0.05), causing oxidative DNA damage (p<0.001) and upregulating antioxidant defenses (p<0.05), while autophagosome load remained unchanged. These findings indicate potential risks to mammalian fertility through functional impairment of the corpus luteum microvasculature. - Source: PubMed
Publication date: 2026/06/19
Basini GiuseppinaBerni MelissaMazzera LauraTambassi MartinaBussolati SimonaQuintavalla FaustoBertini SimoneHeredero Alicia Maria CarrilloGrasselli Francesca - Veal calf mortality remains a major welfare and economic concern, especially during the early post-arrival period in the fattening units. In this prospective cohort study, we examined 934 calves upon arrival at a collection center using a standardized protocol (CLuBS), which includes easy-identify (C)linical signs, ultrasound-detected (Lu)ng lesions, (B)ody weight, and (S)erum total protein. Our goal was to evaluate how these factors associate with subsequent early (≤30 days) and total mortality during the approximately 180-day fattening period in veal calves. To analyze these associations, we used population-averaged logistic regression models with generalized estimating equations to account for clustering by farm of origin. Overall mortality was 11.6% (39/934 early; 108/934 total). In multivariable GEE models, severe lung consolidation (≥ 3 cm) emerged as the strongest predictor of mortality. Specifically, calves without lung lesions had significantly lower odds of early mortality (OR = 0.32; 95% CI: 0.11-0.94) and total mortality (OR = 0.34; 95% CI: 0.19-0.60). than calves with severe consolidation. Furthermore, arrival body weight was inversely associated with mortality, with a 13% reduction in early mortality odds (OR = 0.87; 95% CI: 0.82-0.93) and a 6.5% reduction in total mortality odds (OR = 0.94; 95% CI: 0.90-0.97) per additional kilogram. Additionally, higher rectal temperature was associated with lower odds of early mortality (OR = 0.50; 95% CI: 0.29-0.88; P = 0.015), whereas no association was observed with total mortality. These findings suggest that standardized arrival screening in a collection center, particularly lung ultrasonography and body weight assessment, provides clinically relevant prognostic information for mortality risk stratification in veal calves. - Source: PubMed
Publication date: 2026/06/16
Martucci IlariaGalanti DavideSala GiuliaGazzola ElisaCompiani RiccardoPravettoni DavideBoccardo Antonio - The synchronization of oscillations in spatially extended ecological systems is a pervasive phenomenon. Here, we investigate the spatial synchronization of stochastic predator-prey oscillations in a multi-patch landscape. We model the system using the Rosenzweig-MacArthur model with demographic stochasticity. We demonstrate that the collective phase dynamics of the coupled ecological oscillators can be analytically mapped onto a framework inspired by the XY model of statistical mechanics. In this analogy, migration between patches acts as the coupling strength, while intrinsic demographic noise functions as an effective temperature that promotes disorder. This framework allows us to characterize the emergence of spatial synchrony as a noise-induced phase transition. We analytically and numerically identify the critical migration threshold required for global synchronization and show how the interplay between noise and coupling shapes the system's coherence. Our findings provide a robust statistical mechanics foundation for understanding large-scale ecological synchrony and offer new insights into the resilience of metapopulations. - Source: PubMed
Golmohammadi SolmazZarei MinaGrilli Jacopo - A silicon carbide (SiC) X-ray beam position monitor is presented, based on a resistive charge-division principle derived from lateral-effect photodiodes and specifically adapted for synchrotron radiation applications. This device, referred to as a resistive X-ray beam position monitor (rXBPM), exploits a free-standing SiC membrane combined with a resistive p-doped layer, enabling transmission-mode operation while preserving high radiation hardness and mechanical robustness. In contrast to conventional segmented X-ray beam position monitors, whose response depends strongly on the beam spot size and is typically limited to narrow linear regions, the resistive architecture of the rXBPM provides an intrinsically beam-footprint-independent position signal with an extended linear response region. The detector was fabricated using selective electrochemical etching to realize a thin membrane structure and was experimentally characterized at the microfocus beamline (MiFo) in the PTB laboratory at the BESSY II synchrotron facility using 5.4 keV X-rays. An average transmission of approximately 61% was measured, with good spatial uniformity across the membrane area. Raster-scan measurements demonstrate a linear position response over ranges of ±500 µm and ±1 mm around the detector center, with position sensitivities exceeding 0.157 mm and estimated upper-limit noise-equivalent positions of a few micrometres. Three-dimensional COMSOL simulations were used to model charge transport and lateral charge division in the real device geometry, showing excellent agreement with experimental results and confirming the independence of the position sensitivity from the beam spot size over a wide range of operating conditions. These results establish SiC rXBPMs as a compact, beam spot size calibration-free and radiation-hard solution for beam diagnostics at modern synchrotron light sources, with particular relevance for applications requiring large active areas, extended linearity and minimal beam perturbation. - Source: PubMed
Publication date: 2026/07/01
Trovato GabrieleLa Rosa NiccolòLa Via FrancescoLubeck JaninManno AntonioMoscato SamueleMüller MatthiasCamarda Massimo - The quality of medical services in public hospitals is significantly influenced by managerial styles, which shape organizational efficiency, patient satisfaction, and hospital accreditation outcomes. This study examines the impact of managerial leadership styles and organizational characteristics on accreditation performance in Romanian public hospitals. Using survey data from hospital managers, the study employs a structured analytical approach combining Chi-square tests and cross-tabulations, Kendall's Tau correlations, the Kruskal-Wallis H test, ordinal regression modeling, and exploratory K-means cluster analysis to examine how hospital size, managerial education, employee consultation, team motivation, and access to information are associated with accreditation outcomes. Results indicate that hospital administration type, field of study, and team motivation are significant predictors of accreditation success, while hospital size negatively correlates with accreditation scores, suggesting larger hospitals face greater challenges in meeting accreditation standards. Conversely, employee consultation and information transparency show no statistically significant impact on accreditation performance. These findings highlight the critical role of managerial education and team engagement in achieving higher accreditation outcomes. Strengthening leadership training and team-based quality initiatives could enhance accreditation performance in public hospitals. Policy makers should prioritize managerial development programs and strategic leadership approaches to improve healthcare quality and compliance. - Source: PubMed
Publication date: 2026/06/17
Cumpăt CarmenZouri MuthanaHuţu DanielaGrădinaru AndreeaZouri NicoletaAgheorghiesei Daniela TatianaLega Federico