Ask about this productRelated genes to: CMAS antibody
- Gene:
- CMAS NIH gene
- Name:
- cytidine monophosphate N-acetylneuraminic acid synthetase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-11
- Date modifiied:
- 2015-12-04
Related products to: CMAS antibody
Related articles to: CMAS antibody
- This study aimed to examine the clinical characteristics, triggers and risk factors for gastrointestinal (GI) complications in anti-NXP2-positive JDM (anti-NXP2-JDM) patients. - Source: PubMed
Publication date: 2026/05/22
Yao XinZhang WeiWang XinningChi YingLiu YuanWang XiaoleiNiu WenquanLi Jianguo - Different formulations and routes of administration (e.g. oral, intravenous [IV], subcutaneous [SC]) of the same active pharmaceutical ingredient (API) may change value by altering administration burden, adherence, setting of care and resource use. This systematic review compared the economic impact of alternative formulations or routes of the same API and assessed reporting quality. - Source: PubMed
Publication date: 2026/05/20
Shao HanqiaoJiang YunongZhao MingyeTang Wenxi - Supramolecular hydrogels hold significant potential in drug delivery and tissue engineering, with standing out for their unique properties. Despite their promise, predicting nucleoside bioactivity remains challenging. This study aims to predict the biological activity of nucleosides to guide the rational synthesis of hydrogels. Specifically, nine predictive models and databases for various biological activities were built with feature-selected machine learning methods including decision trees, logistic regression, random forest, and extreme gradient boosting. Then, the Molecular Bioactivity Specificity Index (MBSI) was introduced to gauge the primary bioactivity of nucleoside derivatives, and the Composite Molecular Attribute Score (CMAS) was devised to measure the overall performance of nucleoside derivatives. Subsequently, screening strategies for bioactive nucleoside hydrogels were established, and two candidate hydrogels (GMP and dGMP) with high hydrogel-forming ability, biocompatibility, and antibacterial activity were identified. Finally, two hydrogels were validated for antibacterial treatment of periodontitis. This study highlights the feasibility of ML-based strategies and MBSI/CMAS in rationally designing bioactive nucleoside hydrogels for biomedical applications. The discovery of GMP and dGMP hydrogels and their successful validation in periodontitis models highlight the potential of this strategy for developing targeted therapies for oral diseases. - Source: PubMed
Publication date: 2026/05/11
Li WeiqiWen YinghuiHuang ZhenyuanShuai FangyuanYin YijiaChen QianmingZhu FudongXu HaoZhao Hang - Defective proteostasis is a hallmark of aging cells and tissues. Among the different components of the proteostasis network, in this study, we focus on a selective form of autophagy known as chaperone-mediated autophagy (CMA), and we set out to understand its physiological role in the retina. Using mice deficient for CMA [knockout for lysosome-associated membrane protein type 2A ()], we have found that CMA blockade leads to impaired visual function, altered retinal proteostasis, and photoreceptor cell death. Conversely, mice that overexpress human show higher resistance to chemically induced photoreceptor degeneration and slower visual function decline. We found a similar protective effect against retinal degeneration upon pharmacological activation of CMA. To start elucidating the mechanisms behind CMA's protective role in the retina, we used comparative proteomics and found elevated levels of enzymes related with glucose metabolism in CMA-deficient retinas that phenocopy those observed in old mice retinas. Overall, our results highlight a cytoprotective role for CMA in retina, in part through proteostatic regulation of enzymes involved in glucose metabolism, and support the feasibility of pharmacologically upregulating CMA against retinal degeneration. - Source: PubMed
Publication date: 2026/05/11
Gómez-Sintes RaquelTasset InmaculadaRamírez-Pardo IgnacioMartín-Segura AdriánAlonso-Gil SandraDíaz AntonioLindenau KristenLillo Concepciónde la Villa PedroSidoli SimoneGavathiotis EvripidisCuervo Ana MaríaBoya Patricia - Overlapping clinical manifestations of Mycobacterium tuberculosis (MTB) detection and diseases caused by non-tuberculous mycobacteria (NTM) pose significant diagnostic challenges in tuberculosis-endemic settings. Conventional methods often fail to provide a discriminated diagnosis and/or detect co-detections; however, molecular assays enable precise species-level identification and simultaneous detection of multiple pathogens, thereby enabling detection of multiple mycobacterial species, including co-detection patterns. The purpose of this study is to evaluate the utility of molecular methods for detecting the incidental coexistence of MTB and NTM, thereby supporting improved laboratory-level identification. A total of 890 clinical samples from patients presumed to have a mycobacterial infection were evaluated. The test involved performing AFB smear microscopy, NAAT, MGIT, and MPT64 antigen testing, followed by analysis using the GenoType Mycobacterium CM/AS, which helped identify MTB complex as well as NTM, thus enabling us to identify accidental co-detections that would arise from MTB-NTM. Out of 890 samples analyzed, 27/890 (3.03%) samples turned out to be positive for NTM detection. In this study, 19/27 (70.3%) had only NTM detection, and 8/27 (29.6%) demonstrated MTB-NTM co-detection. Overall, co-detections accounted for 0.89% (8/890) of the total processed samples and 29.6% (8/27) of the samples positive for NTM. The most predominant species was M. fortuitum, which was followed by M. chelonae, and then a case of simultaneous detection with M. avium complex and M. fortuitum along with MTB. In general, it has been seen that M. fortuitum had the highest frequency in such cases. These findings are based on laboratory detection and should not be interpreted as evidence of confirmed co-infection. - Source: PubMed
Publication date: 2026/05/11
Gaikwad ShainaTiwari AntishaAgrawal FalguniKhurana AlkeshKhadanga SagarSingh JitendraPurwar ShashankBiswas DebasisMaurya Anand Kumar