Ask about this productRelated genes to: FSTL5 antibody
- Gene:
- FSTL5 NIH gene
- Name:
- follistatin like 5
- Previous symbol:
- -
- Synonyms:
- DKFZp566D234, KIAA1263
- Chromosome:
- 4q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-05
- Date modifiied:
- 2016-10-05
Related products to: FSTL5 antibody
Related articles to: FSTL5 antibody
- In recent years, the prevalence of myopia has sharply increased in East Asia, emerging as a major public health issue. This study aimed to identify genetic risk factors for myopia progression and to develop polygenic risk score (PRS) models to predict myopia progression risk. Genotyping was performed using the Asian Screening Array chip among 294 Chinese adolescents who completed a 2-year follow-up. A two-stage (discovery cohort: N = 176; replication cohort: N = 118) genome-wide association study (GWAS) was subsequently conducted. Functional annotation and MAGMA analysis were performed to confirm biological relevance of the identified loci in the progression of myopia. Based on GWAS results from the discovery cohort and a European population from the United Kingdom Biobank (N = 460,536), we constructed single-ancestry and cross-ancestry PRS models with PRSice-2 and PRS-CSx. We evaluated the predictive performance of these models using the replication cohort. Our meta-analysis identified seven novel suggestive loci associated with myopia progression, including on 4q32.2, on 9p24.3, on 10p13, on 12q13.13, on 12q23.3, on 17p11.2, and on 17q21.32. For myopia progression risk prediction in East Asians, PRS analysis showed that the East Asian training dataset ( : 5.69%; OR: 1.61, 95% CI: 1.06-2.44; AUC: 0.66) outperformed both the European and cross-ancestry datasets. This study identified seven promising loci associated with myopia progression and demonstrated that PRS exhibited enhanced predictive performance in genetically and phenotypically matched populations. Our findings expand the genetic understanding of myopia progression in East Asian adolescents and provide new insights for myopia prevention and control. - Source: PubMed
Publication date: 2026/04/21
Liu QinyeShen HuiDang XinglunHe Mike ZhongyuWei YizhouShi YingyunWei XiaoyuChen FenHan DiLiu ChengyongHu JiaLiu Weina - The size, composition, and functionality of high-density lipoprotein cholesterol (HDL-C) are potential biomarkers for predicting atherosclerosis, representing a major advance in the prevention and treatment of cardiovascular diseases. - Source: PubMed
Publication date: 2026/01/12
Braga Ribanna A MAlvarenga LiviaAldin Marlene NLeite Jean Michel R SPereira Jaqueline LCerqueira AndressaFisberg Regina MRogero Marcelo MSarti Flavia MDamasceno Nágila R T - [This corrects the article on p. 10325 in vol. 10, PMID: 31966367.]. - Source: PubMed
Publication date: 2025/08/15
Zhang Deng-YongSun Wan-LiangMa XiangZhang PeiWu WeiWu HuanZhou ShuoLu Zheng - This retrospective, cross-sectional study investigated the relationship between body composition and circulating plasma levels of follistatin-like proteins (FSTLs; FSTL1, FSTL4, and FSTL5) in adult survivors of childhood cancer. This is the first study to investigate the association between plasma levels of FSTL4, FSTL5 and skeletal muscle mass. The cohort consisted of 61 CCS (26 females and 35 males) aged 18-36 years (mean age 24.6 ± 4.4 years) who were followed up at the Long-Term Follow-Up Clinic of St. Anne's Hospital in Brno, Czech Republic. The mean age at diagnosis was 10.9 ± 4.9 years, and the mean time after treatment was 12.0 ± 5.1 years. Body composition was assessed using anthropometric indicators and bioelectrical impedance analysis (BIA; InBody 370). Plasma FSTL levels were quantified using commercially available ELISA kits. Correlations were examined by linear regression analysis. A significant negative correlation was found between the FSTL1 plasma level and body fat mass index (BFMI), and a significant positive correlation was observed between FSTL1 and skeletal muscle mass index (SMI). Our results suggest that FSTL1 may be a potential indicator of adiposity and skeletal muscle loss in CCS. - Source: PubMed
Publication date: 2025/05/30
Štrublová LucieZlámal FilipPískovský TomášKučera JanKučerová Jana FialováKepák Tomᚊtěrba JaroslavBienertová-Vašků Julie - To compare central nervous system (CNS) tumors, such as paraganglioma, low-grade glioma (LGG), and glioblastoma (GBM), in terms of driver genes and gene expression, and to investigate the roles of common driver genes and genes with altered expression in cellular proliferation mechanisms and their interactions. - Source: PubMed
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