Ask about this productRelated genes to: PRDM15 antibody
- Gene:
- PRDM15 NIH gene
- Name:
- PR/SET domain 15
- Previous symbol:
- ZNF298, C21orf83
- Synonyms:
- -
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2016-07-18
Related products to: PRDM15 antibody
Related articles to: PRDM15 antibody
- The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians. Here, we investigated genetic risk factors for PD and PDD in Taiwanese individuals from the Taiwan Precision Medicine Initiative (TPMI), the largest non-European cohort integrating genetic and electronic medical record data. - Source: PubMed
Publication date: 2026/03/04
Lin Chin-HsienChang Chien-ChingChen Hung-HsinLin Wan-JiaHsu Chia-LangLin Rung-JuenGuo Yi-JenFang Ting-ChunLin Shinn-ZongHuang Chih-YangWang Shuu-JiunHang Jen-FanHsieh Sun-WungChou Mei-ChuanYeh Tu-HsuehHu Chaur-JongYang Fu-ChiChang Hsin-AnLee Tsong-HaiTsai Meng-HanKuo Ming-CheLiou Jyh-MingWu Ming-ShiangPark Kye WonChung Sun JuTan Eng-KingShen-Jang Fann Cathy - Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. - Source: PubMed
Publication date: 2025/12/16
Zhang Wenbovan der Most Peter JWang SiqiKamali ZohaGiontella AliceEnhörning SofiaGansevoort Ron Tvan der Harst PimBakker Stephan J LMelander OlleKeus FrederikLunter GertonSnieder Harold - Hematopoietic stem cells (HSCs) sustain lifelong hematopoiesis through a tightly regulated balance of self-renewal, proliferation and differentiation, particularly under stress conditions. Here, we identify PRDM15, a transcription factor with well described roles in early embryonic development, as a crucial regulator of hematopoiesis during stress responses. While PRDM15 deletion is tolerated at steady state in adult hematopoiesis, its absence severely impairs bone marrow reconstitution following transplantation, causing sustained reduction in bone marrow cellularity and differentiation blocks. Notably, PRDM15-deleted bone marrow exhibited an accumulation of stem and progenitor cells, indicating a block in lineage differentiation. Furthermore, in competitive transplantation assays, PRDM15-deficient cells were unable to compete with wild-type counterparts, demonstrating a profound loss of fitness. Transcriptomic and epigenomic analyses reveal PRDM15 as a critical regulator of differentiation and proliferation of HSCs. Mechanistically, PRDM15 directly regulates the expression of several key genes involved in proliferation and differentiation pathways, including the transcription factor . overexpression partially rescues colony-forming ability of PRDM15-deficient HSCs. These findings establish PRDM15 as a pivotal stress-responsive regulator of HSC differentiation and survival, with implications for therapeutic modulation of hematopoiesis. - Source: PubMed
Publication date: 2025/11/03
Guccione ErnestoParam NesteeneRialdi AlexTrejo Nayeli GuiterrezFortescue-Poole MaxWang KeZorgati HabibaLozano-Ojalvo DanielSchwarz MaganCantatore FrancescoFonseca FrankPortman KenseyMohammed KevinDominguez-Sola DavidMzoughi SlimWagenblast Elvin - Gastric cancer (GC) has shown relatively poor responses to existing immune therapies. The extensive infiltration of tissue-resident memory T cells (T) in tumor microenvironment (TME) is associated with better Overall Survival (OS) in patients treated with immune checkpoint inhibitors (ICIs). However, the precise roles of T cells in cancer immunity and responses to ICIs in GC remain poorly understood. - Source: PubMed
Publication date: 2025/11/08
Zhang XinyaoZheng JinsenGuo HantaoSong TiantianXiong Bin - PRDM15, a member of the PRDM family, is critically involved in embryonic development, cell differentiation, and tumorigenesis. However, its specific regulatory mechanisms in tumorigenesis remain poorly understood. This study demonstrates that PRDM15 is significantly upregulated in colorectal cancer (CRC) tissues and positively correlates with advanced pathological staging. Knockdown of PRDM15 inhibits p53-dependent cell proliferation by arresting cell cycle progression and promoting apoptosis, thereby suppressing colorectal carcinogenesis both in vitro and in vivo. Furthermore, PRDM15 depletion enhances the sensitivity of HCT116 cells to the chemotherapeutic agent 5-Fluorouracil (5-FU). Mechanistically, PRDM15 functions as a novel negative regulator of p53, exerting its oncogenic effects by transcriptionally downregulating USP10, which in turn destabilizes p53. These findings underscore the critical role of the PRDM15-USP10-p53 axis in CRC progression, offering new insights into the molecular mechanisms driving CRC and identifying potential therapeutic targets for intervention. - Source: PubMed
Publication date: 2025/10/30
Wu ChongyangSi WenzheLi HanxiaoSheng JiePei FeiLiu XujunSu XinpingWang YingLiu CihangZhang YihuaJiang BinWang WengongYi Xia