Ask about this productRelated genes to: PRDM15 antibody
- Gene:
- PRDM15 NIH gene
- Name:
- PR/SET domain 15
- Previous symbol:
- ZNF298, C21orf83
- Synonyms:
- -
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2016-07-18
Related products to: PRDM15 antibody
Related articles to: PRDM15 antibody
- The maintenance of homeostasis in hematopoietic stem and progenitor cells (HSPCs) is essential for the proper development of the entire hematopoietic system. However, the mechanisms underlying this regulatory equilibrium remain elusive. Here, we report that Prdm15 deficiency in HSPCs induces the accumulation of immature hematopoietic stem cells in mice. A series of transplantation assays shows that these cells display impaired reconstitution capacity and competitive fitness, which are associated with abnormal differentiation trajectories and transcriptional alterations identified by single-cell RNA sequencing. Mechanistically, integrated multi-omics analyses including ATAC-seq and CUT&Tag sequencing of HSPCs indicate that Prdm15 deficiency induces significant transcriptional and epigenetic alterations, particularly affecting the methyltransferase KMT2C and altering H3K4me1 and H3K27ac modifications at the promoters of hematopoietic developmental genes. Collectively, our findings establish PRDM15 as a critical epigenetic regulator of HSPCs, offering valuable insights into the molecular mechanisms underlying hematopoietic homeostasis. - Source: PubMed
Publication date: 2026/07/25
Dong QiwenXiao WeiweiHuang JunsongSun ZhengLiang MinWang MengjiaoWang QingqingZong XinlanLi AnziWang YanSun Zhongsheng - Coronary atherosclerosis underlies life-threatening conditions such as myocardial infarction and stroke, yet its cellular dynamics remain incompletely understood. Here, through single-cell RNA sequencing of 27,941 cells from 56 human coronary segments, we constructed a disease-stage-resolved cellular atlas, revealing pathological remodelling of endothelial cells (ECs) into a progenitor-like state (EC5) with low expression of canonical EC dysfunction signatures. EC5 abundance increased with atherosclerotic stage, and its emergence is driven by PRDM15 through direct transcriptional activation. Analysis of the EC5 interaction network revealed extensive crosstalk with immune cell types, the interaction between which contributed to atherosclerotic progression. Endothelial overexpression of Prdm15 in vivo exacerbated atherosclerosis, while its suppression ameliorated the disease phenotype, with diminished EC5-like cells and immune infiltration. Our findings underscore the central role of EC subtype remodelling in the progression of human coronary atherosclerosis and reveal tractable targets for therapeutic intervention. - Source: PubMed
Publication date: 2026/07/14
Yao FangLi FangzhouGai ShujieChen YinanLiu FeiZhang XingzhongLi JunMao LinGuo LiliangXing KunHuang JuanFu ShufangSun YangChen JinhuaZhang HengChen YihanZhou BingyingWang LiZheng Zhe - Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder, with epidemiological studies consistently reporting a rising prevalence worldwide. Our previous human genetic sequencing analysis identified PRDM15 (PRDI-BF1 (Positive regulatory domain I-binding factor 1) and RIZ1 (Retinoblastoma protein-interacting zinc finger 1) homologous domain-containing protein 15), a transcriptional regulator and a member of the PRDM family, as a novel candidate risk gene for ASD. However, its precise role in brain development and subsequent behavioral outcomes remains unclear. Here, we demonstrate that Prdm15 deficiency in mice recapitulates core autism-like behaviors, including increased repetitive grooming, deficits in social interaction, and impaired social recognition memory. Structural MRI (Magnetic resonance imaging) and histological analyses revealed abnormal hippocampal architecture, characterized by reduced neuronal density in the CA1 (Cornu Ammonis 1) subregion. Through single-cell RNA sequencing of the developing hippocampus in mice, we found that Prdm15 deficiency impaired neurogenic lineage differentiation, leading to an accumulation of neural stem cells and a concomitant reduction in mature neurons, which were associated with transcriptional alterations in these cells. Crucially, conditional ablation of Prdm15 specifically in neural stem/progenitor cells achieved by crossing Prdm15-floxed mice (Prdm15) with the Nestin-Cre strain, was sufficient to partially recapitulate the cellular and behavioral phenotypes observed in constitutive Prdm15-deficient mice. Collectively, our findings identify PRDM15 as a critical regulator of hippocampal neurogenesis and provide evidence that its dysfunction contributes to the pathogenesis of ASD-like behaviors in mice. - Source: PubMed
Publication date: 2026/06/23
Dong QiwenXiao WeiweiSun ZhengSun ZhongshengWang Yan - The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians. Here, we investigated genetic risk factors for PD and PDD in Taiwanese individuals from the Taiwan Precision Medicine Initiative (TPMI), the largest non-European cohort integrating genetic and electronic medical record data. - Source: PubMed
Publication date: 2026/03/04
Lin Chin-HsienChang Chien-ChingChen Hung-HsinLin Wan-JiaHsu Chia-LangLin Rung-JuenGuo Yi-JenFang Ting-ChunLin Shinn-ZongHuang Chih-YangWang Shuu-JiunHang Jen-FanHsieh Sun-WungChou Mei-ChuanYeh Tu-HsuehHu Chaur-JongYang Fu-ChiChang Hsin-AnLee Tsong-HaiTsai Meng-HanKuo Ming-CheLiou Jyh-MingWu Ming-ShiangPark Kye WonChung Sun JuTan Eng-KingShen-Jang Fann Cathy - Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. - Source: PubMed
Publication date: 2025/12/16
Zhang Wenbovan der Most Peter JWang SiqiKamali ZohaGiontella AliceEnhörning SofiaGansevoort Ron Tvan der Harst PimBakker Stephan J LMelander OlleKeus FrederikLunter GertonSnieder Harold