Ask about this productRelated genes to: NR4A1 antibody
- Gene:
- NR4A1 NIH gene
- Name:
- nuclear receptor subfamily 4 group A member 1
- Previous symbol:
- HMR, GFRP1
- Synonyms:
- TR3, N10, NAK-1, NGFIB, NUR77
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2017-03-28
Related products to: NR4A1 antibody
Related articles to: NR4A1 antibody
- The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines divergently selected for IMF (high-IMF: H and low-IMF: L). We used 48 rabbits (24 H and 24 L) belonging to the 9th generation of selection to determine their liver gene expression levels using 3' RNA sequencing. We found 263 DE genes between H and L lines; 114 upregulated and 149 downregulated in the H line. Among them, over 30 genes were related to lipid metabolism, energy homeostasis, glutathione-purine metabolism, and/or molecule transport that could influence the IMF deposition. Of the 263 DE genes, 175 target genes were predicted for 11 DE TFs through the gene regulatory networks. Notably, three TFs, namely ETV1, NR4A1, and IKZF3 appear to modulate gene expression of several putative targets involved in lipid and energy metabolism (e.g., CREM, GDF15, and NR4A2). Functional analysis of DE genes revealed an overrepresentation of 37 enriched terms, including the PPAR signalling pathway (associated genes: CPT1B, CYP4A6, FABP4, and PLIN2) and other lipid metabolism bioprocesses. Collectively, our results enhance the understanding of the liver-muscle crosstalk that contributes to IMF deposition and improvement of rabbit meat quality. - Source: PubMed
Valdés-Hernández JesúsZubiri-Gaitán AgostinaMartínez-Álvaro MarinaBlasco AgustínHernández Pilar - - Source: PubMed
Publication date: 2026/06/12
- NDRG1 protein engages with the orphan nuclear receptor NR4A1, effectively suppressing the transcriptional activity of NF-κB and influencing the inflammatory response. However, the specific roles of the NDRG family and NR4A transcription factors in inflammatory bowel disease (IBD) remain poorly defined, particularly regarding potential differential mechanisms between ulcerative colitis (UC) and Crohn's disease (CD). We hypothesize that NDRG-NR4A interactions are differentially regulated in UC versus CD, contributing to disease-specific modulation of NF-κB signaling and inflammatory responses. Therefore, the aim was to analyze gene and protein expression of both protein families (NDRGs: NDRG1, NDRG2, NDRG3, and NDRG4; and NR4A: NR4A1, NR4A2, and NR4A3), their contributions to UC and CD, and their association with disease severity. In this cross-sectional and comparative study, we assess gene and protein expression of NR4A and NDRG1-4 in 38 UC patients, 10 CD patients, and 18 controls. Gene and protein expression levels were measured by RT-PCR (mucosa) and immunohistochemistry (colonic tissue), respectively. The colonic mucosa from remission UC patients showed upregulation of and the nuclear receptor genes compared with controls. was upregulated in active UC patients compared with controls. was downmodulated in active and remission UC patients compared with controls. All differences were statistically significant ( < 0.05). Decreased gene expression was associated with high-sensitivity C-reactive protein ( = 0.030) and erythrocyte sedimentation rate levels ( = 0.001). Our results provide the first evidence of differential alterations in the NDRG-NR4A axis in UC and CD, which could modulate NF κB signaling and the inflammatory profile differently in each disease, opening the possibility of new therapeutic options. - Source: PubMed
Publication date: 2026/05/26
Fonseca-Camarillo GabrielaFuruzawa-Carballeda JanetteAguilar-León DianaBarreto-Zuñiga RafaelMartínez-Benítez BraulioYamamoto-Furusho Jesús K - Gallbladder cancer (GBC) is a major malignancy of the hepato-biliary tract, often detected at advanced, inoperable stages with limited therapeutic options. Nuclear receptors (NRs), a family of ligand-dependent transcription factors, play key roles in cancer biology and represent promising drug targets. mRNA expression of 48 NRs was profiled in GBC (n = 13) and chronic cholecystitis tissues using the Nanostring nCounter platform, identifying NR4A1 as significantly downregulated. NR4A1 activity was modulated in GBC cell lines using the agonist Cytosporone B (CSNB) or siRNA knockdown, and effects on proliferation, invasion, and cell cycle were assessed by qPCR, flow cytometry, and functional assays. NR4A1 was markedly downregulated in GBC tissues and NOZ cells. CSNB treatment increased NR4A1 expression, reduced migration and invasion, and induced G0/G1 arrest. RNA-seq following CSNB treatment highlighted downregulation of pathways related to cell proliferation. NR4A1 knockdown lead to reduction in epithelial markers and increase in proliferation markers like mki67. NR4A1 loss was also associated with adverse survival outcomes. Our findings highlight NR4A1 as a key tumor suppressor in GBC, whose loss confers proliferative and invasive advantages. Pharmacological activation of NR4A1 effectively counteracts these oncogenic traits, highlighting its potential as a therapeutic target, especially for advanced GBC. - Source: PubMed
Publication date: 2026/06/11
Sarkar Sajib KumarNayek ArnabDash Nihar RanjanDas PrasenjitKumar DeepakSahoo Om SaswatNagar AnandKapoor Vinay KumarShukla RatnakarDhar RubyKarmakar Subhradip - To identify differentially expressed genes (DEGs) associated with diabetic nephropathy and to explore their effects on glomerular podocyte senescence. - Source: PubMed
Publication date: 2026/06/08
Li HuananZhu ZifanShen QiaojunWu YihaoWang LiangShen Weigan