Ask about this productRelated genes to: RXRA antibody
- Gene:
- RXRA NIH gene
- Name:
- retinoid X receptor alpha
- Previous symbol:
- -
- Synonyms:
- NR2B1
- Chromosome:
- 9q34.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-14
- Date modifiied:
- 2016-10-05
Related products to: RXRA antibody
Related articles to: RXRA antibody
- This study aimed to integrate multi-omics analyses with genetic causal inference to identify key genes associated with cisplatin resistance in gastric cancer and to evaluate the potential mechanism by which curcumin enhances cisplatin sensitivity through relevant pathways. - Source: PubMed
Publication date: 2026/04/15
Sun XiaoranWu NaBai XueZhang XiangWang RuiDu ShuaiLiu LiLi Duo - Feed behavior traits are directly linked to the sustainability of pig production. This study aimed to investigate the genetic basis of feeding behavior traits in Landrace and Yorkshire pigs, focusing on genomic regions, quantitative trait loci (QTL), candidate genes, and metabolic pathways associated with these traits. - Source: PubMed
Publication date: 2026/04/10
Gervásio Izally CarvalhoBrito Luiz FAraujo Andre CFanalli Simara LarissaSilva-Vignato BárbaraRocha Artur OBenfica Lorena FerreiraFernanda de Oliveira LeticiaFelício Ament Andrezza MariaMonteiro Moreira Gabriel CostaMoncau-Gadbem Cristina TschornyMello Cesar Aline Silva - Classical acute promyelocytic leukemia (APL) is defined by the presence of the fusion; however, a subset of acute myeloid leukemia (AML) cases presents with morphological and clinical features highly suggestive of APL despite lacking this canonical rearrangement, creating diagnostic and therapeutic dilemmas. We report a 27-year-old woman initially diagnosed with AML characterized by myeloid sarcoma and a predominance of promyelocytes (44%) in the bone marrow. Fluorescence in situ hybridization and RNA sequencing failed to detect , while targeted sequencing revealed mutations in and . Although complete remission was achieved after induction therapy, the response to IA and subsequent CHA chemotherapy regimens was suboptimal. Two years later, the patient relapsed with severe coagulopathy and a marked increase in promyelocytes (71%). Comprehensive genomic re-evaluation at relapse identified a novel fusion and a rare mutation. Notably, transcriptomic analysis demonstrated marked overexpression of and . Based on these molecular findings, treatment with all-trans retinoic acid combined with intermediate-dose cytarabine was initiated, leading to rapid clinical improvement and achievement of complete remission. This case describes a rare AML entity that closely recapitulates the clinical and molecular features of APL in the absence of and suggests that activation of retinoic acid–responsive pathways, potentially mediated by RARA/RXRA overexpression and novel gene fusions, can occur independently of the canonical rearrangement, with important therapeutic implications. - Source: PubMed
Publication date: 2026/04/18
Ma LinaWu Min - Risk assessment and management of endogenous potentially toxic components are critical for promoting the rational clinical use of herbal medicines. However, most herbal medicines lack sufficient safety data in clinical, especially for those with multiple botanical sources. As a commonly used multi-botanical source herbal medicine, Uncariae Ramulus Cum Uncis-derived indole alkaloids (IA-URCU) are primarily responsible for its potential hepatotoxicity in clinical practice. Nevertheless, the underlying mechanism of URCU-induced hepatocyte injury remains unclear. - Source: PubMed
Publication date: 2026/04/06
Yang BinSun XueqianZhang XinyueWang ShuoWang YeWang YumingYang ShenshenShu LexinLi Yubo - Renal fibrosis is a common outcome of chronic kidney disease (CKD), forming a fibrotic niche characterized by fibroblast activation and vascular rarefaction. Currently, there are no effective treatment strategies targeting fibrotic niche. Here, we show that chimeric antigen receptor-modified M2 macrophages (CAR-M2) targeting FAP and secreting interleukin (IL)-4 are delivered via an injectable HAMA-CS hydrogel beneath the renal subcapsule and attenuate renal fibrosis while promoting renal revascularization. The single-cell RNA sequencing reveals the heterogeneity and interaction of stroma and endothelial cells (ECs). A fibrosis-related Cxcr2 EC subset is identified, and its specific depletion effectively mitigates renal fibrosis. Further results reveal that CAR-M2 can release matrix metalloproteinase 2 (MMP2) in close proximity to activate retinoid X receptor alpha (Rxra) in the Cxcr2 ECs and further triggers its mitochondrial autophagy, leading to apoptosis. Our research provides innovative strategies and proof of principle for the immunotherapy of organ fibrosis. - Source: PubMed
Publication date: 2026/03/25
Zhao WenyanZhou XinZhao XingliTian HaoSu YangZhao ShanlanLiu MinZhang QiaoChen LinLi XiaochenLiu DiLi JunxuanLi LangWang YanhongLi XingtongYan JinChen WenLiu BingZhu ChuhongZeng Wen