Ask about this productRelated genes to: GALNT6 antibody
- Gene:
- GALNT6 NIH gene
- Name:
- polypeptide N-acetylgalactosaminyltransferase 6
- Previous symbol:
- -
- Synonyms:
- GalNAc-T6
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-16
- Date modifiied:
- 2016-10-05
Related products to: GALNT6 antibody
Related articles to: GALNT6 antibody
- In recent years, the prevalence of myopia has sharply increased in East Asia, emerging as a major public health issue. This study aimed to identify genetic risk factors for myopia progression and to develop polygenic risk score (PRS) models to predict myopia progression risk. Genotyping was performed using the Asian Screening Array chip among 294 Chinese adolescents who completed a 2-year follow-up. A two-stage (discovery cohort: N = 176; replication cohort: N = 118) genome-wide association study (GWAS) was subsequently conducted. Functional annotation and MAGMA analysis were performed to confirm biological relevance of the identified loci in the progression of myopia. Based on GWAS results from the discovery cohort and a European population from the United Kingdom Biobank (N = 460,536), we constructed single-ancestry and cross-ancestry PRS models with PRSice-2 and PRS-CSx. We evaluated the predictive performance of these models using the replication cohort. Our meta-analysis identified seven novel suggestive loci associated with myopia progression, including on 4q32.2, on 9p24.3, on 10p13, on 12q13.13, on 12q23.3, on 17p11.2, and on 17q21.32. For myopia progression risk prediction in East Asians, PRS analysis showed that the East Asian training dataset ( : 5.69%; OR: 1.61, 95% CI: 1.06-2.44; AUC: 0.66) outperformed both the European and cross-ancestry datasets. This study identified seven promising loci associated with myopia progression and demonstrated that PRS exhibited enhanced predictive performance in genetically and phenotypically matched populations. Our findings expand the genetic understanding of myopia progression in East Asian adolescents and provide new insights for myopia prevention and control. - Source: PubMed
Publication date: 2026/04/21
Liu QinyeShen HuiDang XinglunHe Mike ZhongyuWei YizhouShi YingyunWei XiaoyuChen FenHan DiLiu ChengyongHu JiaLiu Weina - Glioblastoma (GBM), as a high-grade glioma, has high invasiveness and poor clinical prognosis. Manganese is an important trace element, has been proven to be closely related to tumor treatment and tumor immunity. It is necessary to explore the correlation between manganese metabolism-related genes and GBM. - Source: PubMed
Publication date: 2026/01/31
Man YiChen WanyueShen GuoanZhao XuanjieLu JunlinZhang Xuxin - Rare, deleterious germline variants are key contributors to inherited lung cancer (LC) risk. The Genetic Epidemiology of LC Consortium (GELCC) has curated valuable high-risk LC families and is uniquely positioned to uncover rare, high-penetrance variants underlying familial LC (FLC). - Source: PubMed
Publication date: 2025/12/11
Liu YanhongLi YafangByun JinyoungShaw Vikram RPikielny ClaudioPeng BoCheng ChaoTsavachidis SpiridonXiao XiangjunZhu DakaiHan YounghunGorlov Ivan PGorlova Olga YCole MichaelGaba Colette RCrawford Erin LPurrington KristenGoode Ellen LYang PingMcKay JamesField John KLiu GeoffreyHung Rayjean JXia JunChoi JiyeonSchabath Matthew BLoPiccolo JaclynChristiani David CBailey-Wilson JoanSchwartz Ann GWilley James CMandal DiptasriPinney Susan MAmos Christopher I - Increased expression of the polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6), an O-glycosyltransferase, has been reported to play a crucial role in mammary carcinogenesis. Here, we demonstrate that GALNT6 O-glycosylates Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/Bip), a key regulator of the unfolded protein response (UPR), by adding N-acetylgalactosamine (GalNAc), thereby modulating its stability in breast cancer cells. Functional inhibition of either GALNT6 or GRP78/Bip suppressed the proliferation of the luminal-type breast cancer cell line, ZR-75-1, understanding their importance in tumor cell growth. We further found that GRP78/Bip, which is primarily localized in the endoplasmic reticulum (ER), is transported to the Golgi apparatus under the ER stress conditions, where it undergoes O-glycosylation at Thr203 by the Golgi-resident GALNT6. Substitution of Thr203 with alanine inhibited the binding of GRP78/Bip to IRE1, an ER stress sensor, suggesting that the O-glycosylation at Thr203 in GRP78/Bip facilitates sustained activation of the UPR. These findings define the GALNT6-GRP78/Bip axis as a novel mechanism driving persistent UPR activation and tumor cell adaptation to ER stress, offering a potential new therapeutic target for luminal-type breast cancers. - Source: PubMed
Publication date: 2025/10/24
Uchiyama KeijiHagiwara KoseiMatsushita YosukeYoshimaru TetsuroOno MasayaSasa MitsunoriKatagiri Toyomasa - [This corrects the article on p. 2419 in vol. 8, PMID: 30662801.]. - Source: PubMed
Publication date: 2025/09/25
Duan JingChen LinGao HuabinZhen TiantianLi HuiLiang JiangtaoZhang FenfenShi HuijuanHan Anjia