Ask about this productRelated genes to: VSIG4 antibody
- Gene:
- VSIG4 NIH gene
- Name:
- V-set and immunoglobulin domain containing 4
- Previous symbol:
- -
- Synonyms:
- Z39IG, CRIg
- Chromosome:
- Xq12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-10
- Date modifiied:
- 2018-07-13
Related products to: VSIG4 antibody
Related articles to: VSIG4 antibody
- Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the concept of gut microbiota-derived nanoparticles (GNPs) in disease pathogenesis. When isolated BNPs were administered in an ALD mouse model, they upregulated Vsig4 receptor expression in liver macrophages, improving phagocytic clearance of harmful GNPs that contained bacterial DNA. GNPs activated liver inflammation via the cGAS-STING pathway, exacerbating ALD and liver fibrosis in Vsig4-deficient mice. BNP treatment suppressed the inflammatory cascade, modulated macrophage polarization, and reduced hepatic steatosis and liver injury, while also restoring the balance of the gut microbiota and enhancing intestinal barrier function. These findings reveal the role of GNPs in ALD pathogenesis and present targeted microbial nanoparticle postbiotics as potential therapeutics for treatment of alcohol-associated and other liver diseases. - Source: PubMed
Publication date: 2026/04/30
Gu ZelinMeng ShuhanYao BoqingGao BoyaChen SiyeRen FazhengLi PinglanShao TuoShang Nan - Liver metastases can resist T cell immunotherapies, indicating an adaptation of metastatic tumors toward reduced immunogenicity in the liver. Here we show that VSIG4, an immune checkpoint molecule predominantly expressed by Kupffer cells, has an opposing function in determining the growth of liver metastases with distinct antigenicity by modulating cognate T cell antigen receptor signaling through an interaction with CD5. VSIG4-CD5 engagement impedes activation of low-affinity CD8 T cells while enhancing responses of high-affinity CD8 T cells by rescuing them from activation-induced cell death. This bidirectional regulation favors the outgrowth of poorly immunogenic metastatic tumor clones and fosters an immune landscape that is unfavorable to T cells as metastatic liver cancer progresses. We also show that blockade of VSIG4-CD5 interaction using a nanoantibody to VSIG4 sensitizes liver metastases to anti-PD-L1 therapy, achieving synergistic efficacy in mice. These findings provide mechanistic insights into cancer immunoediting during liver metastasis and a possible approach for treating immunologically cold tumors. - Source: PubMed
Publication date: 2026/04/29
Zhou XiaLiu WeiHu JingYao QiZhang FutingWu QiLi LiyaLi JiajiaZhu LixiaChen ChenZhang QingZhang RenjieLiu JinlingShi ChaoweiZhou HongGuo AoWang JianWang JizhouHu QingsongLi LuJin TengchuanZeng Zhutian - The complement receptor immunoglobulin (CRIg), a key microbial pathogen phagocytosis-promoting receptor, responsible for intravascular clearance of bacteria, is purported to be expressed selectively on tissue-fixed macrophages such as Kupffer cells. However, recently it has been reported that neutrophils can also express functional CRIg following activation by inflammatory mediators. Monocytes have been reported not to express CRIg under non-activated conditions. Thus, investigations were undertaken to examine whether blood monocytes express CRIg under cell activation conditions and its role in anti-microbial immunity. - Source: PubMed
Publication date: 2026/03/13
Perveen KhalidaYang GailinSkurray Cameron DNgo AndyBlack NikkiPutty TrishniPatel AsmitabahenSmall Annabelle GGulam Muhammad YWechalekar Mihir DSadlon TimothyBarry Simon CQuach AlexHii Charles SFerrante Antonio - Kupffer cells (KCs), the prenatally seeded macrophages of the liver, show unique functional and immunophenotypic features among tissue-resident macrophages. They are considered as terminally differentiated with negligible cellular postnatal input. Their adaptability in disease is attributed to recruited, monocyte-derived KCs. Here, we explored KC plasticity and the impact of their ontogeny in persisting mycobacterial infections, which primarily target macrophages. - Source: PubMed
Publication date: 2026/03/04
Neuber JanaLohrmann FlorensWald SamuelGöçer MerveLösslein Anne KathrinObwegs DavidRogg ManuelGres VitkaKolter JuliaGoldmann TorstenWalter KerstinHölscher ChristophSchell ChristophPreissl SebastianSagar Henneke Philipp - Sepsis, involving systemic inflammation and organ failure, presents significant challenges due to its complex and heterogeneous immunological reactions. T-helper 17 (Th17) cells contribute significantly to immune regulation, and their dysregulation is implicated in sepsis pathogenesis. Understanding how Th17 cell differentiation-related genes contribute to sepsis heterogeneity and prognosis is crucial for improving patient prognosis. - Source: PubMed
Publication date: 2026/02/27
Li XiuhuaTan LifeiDing YingweiZhang Bingwen