Ask about this productRelated genes to: SLC25A24 antibody
- Gene:
- SLC25A24 NIH gene
- Name:
- solute carrier family 25 member 24
- Previous symbol:
- -
- Synonyms:
- DKFZp586G0123, APC1
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-05
- Date modifiied:
- 2016-10-05
Related products to: SLC25A24 antibody
Related articles to: SLC25A24 antibody
- Auricular dysplasia is a common fetal anomaly. Despite existing studies in postnatal populations, there remains a paucity of prenatal data on genetic etiology and prognostic analysis for this condition. This study aimed to analyze the genetic etiology and associated postnatal outcomes of auricular dysplasia, in order to provide guidance for prenatal genetic counseling. - Source: PubMed
Publication date: 2026/04/15
Zhu YuanhangHan XiaoOuyang XuezheChu TiantianLi NaiqiYang JieCheng XinLiu Ling - Hepatocellular carcinoma (HCC) is a significant global health burden. Cancer cells often exhibit an imbalance in intracellular calcium homeostasis. This study aims to explore the relationship between calcium-related genes and the prognosis of HCC, and establish a prognostic model based on calcium-related genes. - Source: PubMed
Publication date: 2026/03/21
Chen YanlingMa YarongZhao GuoruiLi JianhaoZhang Guizhen - The identification of functional ligand-membrane protein interactions under native conditions remains a major challenge in cancer biology. Using cell-systematic evolution of ligands by exponential enrichment, we identified a high-affinity DNA aptamer, CW06, against breast cancer cells. To precisely identify its native membrane target, we developed Aptamer-mediated Metabolic Glycan-labeling Proximity Hybridization (Apt-MGPH), which revealed the mitochondrial solute carrier SLC25A24 as the specific target. Unexpectedly, CW06 treatment upregulated SLC25A24 expression, disrupting methionine metabolism, depleting cytosolic SAM, and inducing G1 cell cycle arrest and senescence via the p21-HMGA1 axis. In mouse xenograft models, CW06 significantly inhibited tumor growth without affecting healthy tissues. Targeted degradation of SLC25A24 reverses these effects, confirming its regulatory role in the metabolism-senescence axis. Our study establishes Apt-MGPH as a robust tool for membrane target identification and highlights aptamer-induced target overexpression as a strategy for cancer therapy. - Source: PubMed
Publication date: 2026/03/23
Cui WeiXiao HangWen XiaohongLi ChenBao SuxiaZeng JiahaoLi YangbingQiao YanWang KeminWang HonghuiHuang JinGuo Qiuping - Spinal cord injury (SCI) significantly impacts patients, with mitochondrial dysfunction playing a critical role in its pathology. Identifying mitochondria-related genes may offer new therapeutic and prognostic insights. - Source: PubMed
Chen HaifengCai WeiZhang YunpengTang XiaomingDai JianLi YaoMa Jian - A genome-wide knockout screen identified members of the SLC25 family of mitochondrial carrier proteins as important regulators of the rate of de novo mitochondrial protein synthesis. To elucidate this relationship, we generated human cell knockouts for SLC25A25, SLC25A44, SLC25A45, and SLC25A48, which have been shown to exchange adenosine triphosphate-magnesium (ATP-Mg) and phosphate, branched-chain amino acids, methylated basic amino acids, and choline, respectively. Multiomic and functional analyses identified that these four carriers are crucial for mitochondrial translation, biogenesis and function of the oxidative phosphorylation system, as well as mitochondrial morphology. Thermostability screens showed that SLC25A48 is specifically stabilized by choline, and changes in the mitochondrial metabolome and lipidome indicated defects in choline biosynthetic pathways and remodeling of mitochondrial membranes, both consistent with SLC25A48 being a choline transporter. These results highlight the essential roles of specific SLC25 transporters in maintaining mitochondrial structure and function and show that impaired transport of branched-chain amino acids, methylated basic amino acids, ATP-Mg, and choline affects mitochondrial translation. - Source: PubMed
Publication date: 2026/02/25
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