Ask about this productRelated genes to: SLC11A1 antibody
- Gene:
- SLC11A1 NIH gene
- Name:
- solute carrier family 11 member 1
- Previous symbol:
- LSH, NRAMP, NRAMP1
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-21
- Date modifiied:
- 2016-02-17
Related products to: SLC11A1 antibody
Related articles to: SLC11A1 antibody
- Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis type 13 (ALS13) are triggered by polyglutamine expansion in Ataxin-2 (ATXN2). To understand these neurodegenerative disorders at the molecular level, the brains of 10-month-old -CAG100-knockin mice were analyzed as microglial, astroglial and neuronal fractions via global RNA sequencing. Data were validated by comparison with the spinal cord oligonucleotide microarray profile or filtered by RNA-seq consistency. Here, we show that the mutation causes a massive inflammatory response in microglia and a reciprocal loss of neuronal transcripts in glial fractions, suggesting severe synapse loss. Beyond these general neurodegenerative signs, we identify pathognomonic changes in the machinery for protein translation and RNA splicing. Glial fractions showed upregulation of (to 2082%), , , , , , , , and as an unspecific neuroinflammatory signature, versus downregulation of axonal (to <19%), and synaptic , , , and mRNAs correlating with circuit disconnection. In all fractions, reductions in , , and were noted versus disease-specific inductions of ribosomal subunits, presumably mirroring the partial loss-of-function of ATXN2 as RNA translation modulator. Selective accumulations of embryonic factors and versus downregulation of adult specify the mutation impact on splicing and translation elongation. As a potential underpinning of toxic gain-of-function, the proteostasis transcript appeared increased in astroglial and microglial fractions. These transcriptome data suggest altered ribosomal and spliceosome machinery, with massive microgliosis versus mild astrogliosis, at the core of SCA2 and ALS13. - Source: PubMed
Publication date: 2026/04/15
Auburger GeorgKandi Arvind ReddyVutukuri RajkumarAlmaguer-Mederos Luis-EnriqueGispert SuzanaSen Nesli-EceKey Jana - While typhoid fever affects both sexes at an equal rate, males are at a higher risk for intestinal perforation, which increases mortality. The mechanisms behind the increased morbidity of typhoid fever in human males remain an important but understudied question. Using a 129X1/SvJ (NRAMP []) murine model of typhoid chronic infection, we determined that males in this model exhibit increased bacterial burden and mortality in comparison to females (median survival 7 vs 11 days post-infection, respectively). This decreased survival in males was influenced by the diet preceding infection as male mice fed a lithogenic diet, to induce gallstones important to chronic infection, or a normal diet had a lower median survival time, although no difference in the overall probability of survival was observed. We also explored how the systemic immune response may contribute to increased mortality by comparing serum cytokine levels between males and females. Males had higher overall levels of pro-inflammatory cytokines and IL-10 and lower levels of IL-27, which are known to inhibit the protective responses to infection. Together, we present the first report that the 129X1/SvJ murine model of infection responds to infection in a sex-dependent manner, characterized by maladjusted systemic cytokine production and increased bacterial burden in males. - Source: PubMed
Publication date: 2026/03/11
Bennett Aliyah NCole Allysa LGunn John S - Buffalo calves are highly susceptible to neonatal calf diarrhea (NCD), a major cause of morbidity, mortality, and economic loss in livestock production. Among the viral agents responsible, bovine viral diarrhea virus (BVDV) is one of the most common causes of NCD. The infection leads to significant financial losses due to calf mortality, treatment costs, reduced growth performance, and increased susceptibility to secondary infections. The study's goals were to examine the connections among SNPs, gene expression, the serum profile of biochemical and APPs marker changes, and the molecular detection and prevalence of BVDV in Egyptian diarrheal calves. Blood samples were obtained from 100 neonatal buffalo calves that were diarrheal and 100 that seemed healthy. The blood samples were then separated into EDTA tubes for whole blood collection used for RNA extraction and plain tubes (without anticoagulant) for serum collection. One hundred fecal samples were collected from diarrheic group for BVD screening using polymerase chain reaction (PCR), and those that tested positive with relatively high viral loads were further examined using PCR to amplify specific gene regions: the 5'UTR gene for BVD. Gene expression profile and nucleotide sequence variation for immune and antioxidant markers were assessed in healthy and diarrhea affected calves. BVDV was detected in 20% of the samples, according to PCR data. When the detected strains were matched to reference strains in Genbank, their identities ranged from 84.1 to 100%. Five identified samples' partial 5'UTR gene nucleotide sequences were uploaded to GenBank and assigned the accession codes PV243153, PV243154, PV243155, PV243156, and PV243157. Diarrheic group gene expression levels of SLC11A1, CD14, PTX3, IRF3, and ST1P1 were considerably (P < 0.05) higher than those of the control group. PRDX2, PRDX6, and GPX, on the other hand, were in the opposite range. Differences in the nucleotide sequences of the genes under investigation were observed between the diarrheic and healthy calves. Serum levels of APPs (Hp, SAA, Cp), ALT, AST, GGT, LDH, BUN, creatinine, triglyceride, cortisol and CRP were significantly (P˂0.05) increased in diarrheal buffalo calves, while serum levels of glucose, total protein, albumin, globulin, calcium, phosphorus, sodium, copper, zinc and iron were decreased. The findings of the study suggest that BVD is widespread in Egypt. The study's conclusions suggest that by using gene expression profiles and nucleotide sequences in genes related to immunity and antioxidants, buffalo calves could be chosen by marker-assisted selection (MAS) to predict and prevent diarrhea. Biochemical and APPs markers, as well as gene expression profiles and nucleotide sequence of genes under investigation, may also be used as proxy biomarkers for buffalo calves' diarrhea in order to make an effective management protocol, create effective vaccines, control strategies, and identify the most vulnerable risk period for disease occurrence. - Source: PubMed
Publication date: 2026/03/10
El-Sayed Ahmed ANoaman Eman ARagab Mohamed THafez AmaniMahmoud Mona AEl-Naggar Ahmed LOsman Wafaa A - - Source: PubMed
Publication date: 2026/02/17
Bodur MahmutVidović BojanaNikolaou AnastasiosYilmaz Birsen - Hypertension is a multifactorial condition of unknown cause that affects more than 1.28 billion adults worldwide and impacts the sexes differently. The hypothalamic paraventricular nucleus (PVN) plays a central role in blood pressure (BP) regulation by modulating sympathetic tone and releasing neuropeptides that affect the cardiovascular function. In this study, we investigated the transcriptomic profile of the PVN in hypertensive strains and across sexes, aiming to identify novel sex-specific molecular pathways involved in the regulation of BP. - Source: PubMed
Publication date: 2026/02/21
Duque V JNani J VJovanovic MLozić MŠarenac OPauža A GMurphy D MJapundžić-Žigon N ZMecawi A S