Ask about this productRelated genes to: SLC11A1 antibody
- Gene:
- SLC11A1 NIH gene
- Name:
- solute carrier family 11 member 1
- Previous symbol:
- LSH, NRAMP, NRAMP1
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-21
- Date modifiied:
- 2016-02-17
Related products to: SLC11A1 antibody
Related articles to: SLC11A1 antibody
- Macrophages play critical roles in tumorigenesis and progression; however, their functions in renal cell carcinoma (RCC) remain insufficiently characterized. In this study, we leveraged multiple perspectives, including bulk transcriptomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics, to conduct an integrated analysis of various databases. We identified two macrophage-associated gene signatures, SLC11A1 and IFI30, and established a classifier based on these genes that correlates with different RCC prognoses and molecular patterns. This classifier significantly predicts adverse outcomes for RCC patients and demonstrates marked differences in drug sensitivity analysis and immune infiltration. Furthermore, we conducted an in-depth analysis at the scRNA-seq and spatial transcriptomics levels to characterize the pseudotime trajectory, metabolism, and communication of macrophages expressing SLC11A1 or IFI30. We also validated the expression and functional impact of these two genes in tumor cell lines through clinical samples and in vitro experiments. This study emphasizes the significant association between macrophages and the diverse clinical features and molecular landscapes of RCC. Evaluating the characteristics of macrophages in RCC enhances our understanding of the tumor microenvironment and paves new avenues for targeted therapeutic strategies for RCC. - Source: PubMed
Publication date: 2026/08/11
Duan JingjingLiu XianglinZeng FangmeiTang HaoTang YuanjieLu KaiyiQu LeZhang WentaoWang LinhuiYang JianfengJin YumingLiu Wenqiang - Phytogenic feed additives encompass a broad category of plant-derived compounds that are used to improve animal health and production performance. Essential oils, as a volatile subclass of phytogenics extracted from plant materials, are recognized for their antimicrobial, antioxidant, and immunomodulatory properties and have been increasingly investigated as alternatives to antibiotic growth promoters in broiler nutrition. The study objective was to evaluate the effect of garlic and black seed oils on live broiler growth performance, immunity, and related gene expression. A total of 560 day-old Indian River broiler chicks were assigned randomly in a completely randomized design to one of four dietary groups, with each treatment consisting of 7 replicates (20 birds per replicate): control (CON; = 140), garlic oil supplemented diet (200 mg/kg feed garlic oil, GO; = 140), black seed oil supplemented diet (150 mg/kg feed black seed oil, BSO; = 140), and the mixed oils group (200 mg/kg, 150 mg/kg for garlic and black seed oils, respectively, GO+BSO; = 140). Supplementation with GO or BSO individually enhanced final body weight ( = 0.0356) and feed conversion ratio ( = 0.0407). White blood cell counts were lower in the treatment groups ( = 0.035). Serum triglycerides, VLDL, and AST levels were significantly reduced in the treatment groups ( < 0.05). counts were lower in the treatment groups ( = 0.0006). Gene expression analysis revealed significant downregulation of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) and AvBD9, alongside upregulation of LEAP-2 and SLC11A1 in liver and spleen tissues. Dietary supplementation with garlic oil or black seed oil significantly enhanced broiler growth performance, lipid metabolism, immune function, and gut microbiota balance. The combined treatment (GO+BSO) did not produce additive or synergistic effects, suggesting overlapping mechanisms of action. These findings support GO and BSO as effective multifunctional alternatives to antibiotic growth promoters in sustainable poultry production. - Source: PubMed
Publication date: 2026/07/15
Obeidat Mohammad DKhafajah Ghassan ARiley David G - SLC11A1 is a key gene involved in the regulation of innate immunity, and its expression level is closely associated with disease resistance in livestock and poultry, making it an important candidate gene for disease-resistant breeding. The functional characteristics of the promoter region are central to deciphering the transcriptional regulatory mechanisms of a gene. In this study, we focused on the chicken SLC11A1 gene and retrieved sequences flanking the transcription start site (TSS) from the NCBI database. By integrating bioinformatic analysis with a dual-luciferase reporter assay system, we systematically identified the core promoter region and functionally characterized the regulatory roles of cis-regulatory element and their associated transcription factor binding profiles. Results revealed a canonical TATA-box element located at -31 bp to -28 bp upstream of the TSS of the chicken SLC11A1 gene. Functional analysis using a series of truncated luciferase reporter constructs demonstrated that the region from -172 bp to +19 bp constitutes the core promoter of the chicken SLC11A1 gene, with the segment from -172 bp to -36 bp being essential for basal transcriptional activity, the TATA-box was shown to synergistically enhance transcriptional efficiency when combined with this region. Prediction of transcription factor binding sites indicated that Sp1 exhibited the highest binding frequency within the core promoter, followed by C/EBPalpha and other factors. These findings define the fundamental regulatory architecture of the chicken SLC11A1 promoter, providing essential insights for future studies on the transcriptional regulation and biological functions of SLC11A1. - Source: PubMed
Publication date: 2026/07/02
Wang MengjieWang JingjingWang XiaoyaZhang LijieLiu XinranGao QianmeiLi QingheZhao Guiping - Tuberculosis (TB) remains a major infectious disease burden, and inter-individual heterogeneity in progression from exposure to active disease suggests contributions from host genetic factors. SLC11A1 (formerly NRAMP1) encodes a phagosomal divalent cation transporter implicated in macrophage-mediated antimicrobial defense; the non-synonymous rs17235409 polymorphism (D543N) has been evaluated in multiple populations with inconsistent results. We conducted a retrospective matched case-control study in Qiandongnan, Guizhou Province, China, including 50 patients diagnosed with TB (2022-2023) and 50 healthy controls frequency-matched by ethnicity and selected demographics. Participants were drawn from Miao, Dong, and other minority groups. Among TB cases, the frequencies of the GG, GA, and AA genotypes were 80.0%, 20.0%, and 0%, respectively, compared with 74.0%, 18.0%, and 8.0% among controls. The overall genotype distribution did not differ significantly between the 2 groups (P = .124). Under the dominant model, no significant association was observed between rs17235409 and TB susceptibility (OR = 0.71, 95% CI: 0.28-1.82; P = .635). Allelic analysis showed that the frequency of the A allele was lower in cases than in controls (10.0% vs 17.0%), but this difference was not statistically significant (OR = 0.54, 95% CI: 0.24-1.25; P = .214). Ethnicity-stratified analyses similarly showed no statistically detectable associations in Miao, Dong, or other groups. The minor allele frequency was 0.095, lower than the Han Chinese reference from 1000 Genomes. In this pilot study of multi-ethnic populations from southwestern China, no statistically significant association was identified between the SLC11A1 rs17235409 polymorphism and tuberculosis susceptibility. Although the A allele appeared less frequent among cases, the limited sample size and statistical power preclude definitive conclusions regarding modest or ethnic-specific effects. These findings provide preliminary genetic data from underrepresented ethnic minority populations and warrant validation in larger multicenter studies. - Source: PubMed
Chen ChaoGu DianjuXie Yunmi - Intra-abdominal infection frequently progresses to sepsis, where the liver is an early and commonly injured organ. In a cecal ligation and puncture (CLP) mouse model combined with bulk and single‑cell RNA sequencings, we observed marked neutrophil infiltration in the liver that correlated with injury severity. Sepsis‑associated neutrophils displayed a pro‑inflammatory phenotype and specifically upregulated the divalent metal transporter solute carrier family 11 member 1 (SLC11A1). Conditional knockout of Slc11a1 in neutrophils (Ly6G-Cre Slc11a1) significantly alleviated liver injury and improved survival. Mechanistically, SLC11A1 drives intracellular Fe accumulation and reactive oxygen species production via the Fenton reaction, promoting the formation of neutrophil extracellular traps (NETs). Hepatocytes were found to secrete C-X-C motif chemokine ligand 10 (CXCL10) through nuclear factor kappa B (NF‑κB) activation, which both recruit neutrophils and stimulates the JAK/STAT1/SLC11A1 axis, thereby enhancing NETs‑mediated pro‑inflammatory macrophage polarization. Clinically, peripheral blood CXCL10 levels correlated with liver injury markers in sepsis patients. Neutralization of CXCL10 using an anti-CXCL10 antibody or liver-specific knockdown of CXCL10 via Adeno-Associated Virus (AAV) reduced NETs formation and attenuated liver damage in CLP mice. This study delineates a "CXCL10-SLC11A1-NETs" signaling axis that exacerbates sepsis‑induced liver injury, offering a novel target for therapeutic intervention. - Source: PubMed
Publication date: 2026/07/13
Lin HaipingZheng ShicongSong PeiChang JieChen ZeweiLi CangYu MinWang LudeYu Shian