Ask about this productRelated genes to: SC4MOL antibody
- Gene:
- MSMO1 NIH gene
- Name:
- methylsterol monooxygenase 1
- Previous symbol:
- SC4MOL
- Synonyms:
- DESP4, ERG25
- Chromosome:
- 4q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-02-28
- Date modifiied:
- 2017-12-15
Related products to: SC4MOL antibody
Related articles to: SC4MOL antibody
- Obesity and its associated disorders of glucose and lipid metabolism have become increasingly significant public health concerns. Bariatric surgery is an effective intervention for severe obesity and related metabolic comorbidities. This study aims to investigate the effects of bariatric surgery on glucose and lipid metabolism in high-fat diet (HFD)-induced obese mice. - Source: PubMed
Guo ZhonghaoZhao ShengjieWang WeiLi Ruibin - Long noncoding RNAs (lncRNAs) have emerged as critical regulators of lipid metabolism in mammals; however, their biological roles and molecular mechanisms in avian species remain largely unexplored. To investigate the potential involvement of hepatic lncRNAs in lipid metabolism associated with laying performance, we performed transcriptome sequencing of liver tissues from high- and low-yielding Taihang hens, identifying 87 differentially expressed lncRNAs (DELs) and 264 differentially expressed genes (DEGs). The DEGs, including MSMO1, NSDHL, FADS2, PLIN2, and GPAM, were significantly enriched in lipid metabolic pathways, highlighting the potential importance of hepatic lipid biosynthesis in laying hens. Among the DELs, ENSGALT00000106907 (lncRNA106907) was markedly upregulated in high-yielding hens and exhibited positive expression correlation with GPAM, a rate-limiting enzyme in triglyceride synthesis. Functional assays in leghorn male hepatoma (LMH) cells demonstrated that overexpression of either lncRNA106907 or GPAM enhanced intracellular triglyceride (TG) and total cholesterol (TC) accumulation, enhanced lipid droplet content, and altered the expression of multiple lipid metabolism-related genes, whereas knockdown produced opposite effects. In addition, lncRNA106907 positively affected GPAM expression, supporting a functional association between lncRNA106907 and GPAM in hepatic lipid metabolism. Collectively, our findings identify lncRNA106907 as a novel cytoplasmic lncRNA associated with hepatic lipid deposition via GPAM and provide new insight into lncRNA-mediated lipid metabolic regulation in chickens. - Source: PubMed
Publication date: 2026/05/25
Bai YingShao TianjiaoWei XiaohuaGao YahuiChu QinYuan RuiChang ShiminLiu Lei - In recent years, the immunomodulatory role of adipose tissue (AT) has gained attention, yet the metabolic basis for immune homeostasis in AT remains unclear. Catecholamines (CAs) activate adipocyte β3-adrenergic receptors (β3-AR) to promote lipid metabolism, while cholesterol metabolism has bidirectional immunoregulatory properties. Whether the interaction between CAs and cholesterol regulates immune function in AT is unknown. Using chickens as models, we induced distinct immune states via dexamethasone (Dex) treatment and Newcastle disease virus (NDV) vaccination. Through qRT-PCR and metabolomics, we analyzed dynamic changes in lymphocytes, CAs, and cholesterol metabolism in AT. The results indicated that B cells were present in chicken AT and positively responded to different immune states through up-regulation. AT positively responded to Dex-induced immunosuppression (DIIS) and NDV-induced immune responses by altering cholesterol and CAs metabolisms. Moreover, the differences in cholesterol and CAs metabolisms were the key ways by which Dex affected immune response in AT. AT could synthesize bile acids and steroid derivatives, and secondary immunization possible was the key stage with active changes in cholesterol derivatives in AT. We identified a circuit pathway: "lymphocyte-catecholamine-adipocyte-cholesterol-cholesterol derivatives-lymphocyte," which may underpin immune microenvironment homeostasis in AT. Additionally, miR-206 was actively involved in the processes of DIIS, and the miR-206/MSMO1 pathway potentially regulated cholesterol metabolism in AT. This study provides a perspective for in-depth understanding of the immune regulation mechanism of AT and offer a direction for developing cholesterol derivatives for immune regulation. - Source: PubMed
Publication date: 2026/04/27
Li JiaJiang YiXia MeiqiZhang YuxinLin JiayiRen LiruWang XiangnanMan Chaolai - As an important economic trait in ducks, residual feed intake (RFI) may be influenced by the intestinal microbiota. However, the mechanisms underlying microbiota-host crosstalk remain unclear. - Source: PubMed
Publication date: 2026/04/21
He ZhiyuChi XuliRuan ShiyingLin RulongChen HongpingCai KaixianYe XiaolongHu JiweiHe HuaLi LiangLiu HeheWang Jiwen - The quality of follicular development is a primary determinant of reproductive performance in female livestock and is governed by the functional state of granulosa cells (GCs). Androstenedione (ASD), a key steroid precursor converted within the ovary to estrogens and androgens via multiple pathways, has recognized biological roles. However, its direct regulatory actions in GCs and their consequences for sow fertility remain insufficiently defined. By comparing ovarian metabolomes from high and low reproductive performance sows, we pinpointed differentially abundant metabolites and prioritized ASD for mechanistic investigation. We then systematically characterized ASD function in primary porcine GCs in vitro and validated mechanisms using transcriptomics and gene overexpression. Our data support a model in which ASD acts via an ASD-MSMO1 axis and may engages canonical TGF-β, AMPK, p53, Hedgehog, Apelin, FoxO, and Hippo signaling pathways to orchestrate multilayered regulation of GC physiology, promoting proliferation, enhancing estrogen and progesterone synthesis and secretion, and inhibiting apoptosis. These findings provide mechanistic insights and suggest feasible strategies to improve fertility in female livestock. - Source: PubMed
Publication date: 2026/03/25
Yi LeiLiu JingwenChen WenwuXiao LanlinChen BoheLiu XiaolinLiu CaihongXu XinFu XianchuangLiufu SuiMa Haiming