Ask about this productRelated genes to: CLIC5 antibody
- Gene:
- CLIC5 NIH gene
- Name:
- chloride intracellular channel 5
- Previous symbol:
- -
- Synonyms:
- DFNB102
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-10-31
- Date modifiied:
- 2016-10-05
- Gene:
- CLIC6 NIH gene
- Name:
- chloride intracellular channel 6
- Previous symbol:
- CLIC1L
- Synonyms:
- CLIC5
- Chromosome:
- 21q22.12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-08-28
Related products to: CLIC5 antibody
Related articles to: CLIC5 antibody
- The chloride intracellular channels (CLICs) engage in cancer pathogenesis and have been considered various cancer biomarkers and therapeutic targets. Preliminary research suggests CLICs may be important players in head and neck squamous cell carcinoma (HNSCC). There is a need for reliable HNSCC biomarkers besides well-known HPV and PD-L1. - Source: PubMed
Publication date: 2025/10/24
Wojtera Bartosz PawełOstrowska KamilaOstapowicz JuliaSzewczyk MateuszKozikowska JuliaSuchorska Wiktoria MariaGolusiński Wojciech - The chloride intracellular channels (CLICs) family includes six ion channels (CLIC1-CLIC6) expressed on the cellular level and secreted into interstitial fluid and blood. They are involved in the physiological functioning of multiple systems as well as the pathogenetic processes of cancer. CLICs play essential roles in the tumor microenvironment. The current systematic review aimed at identifying and summarizing the research of CLICs in oncology on clinical material to assess CLICs' potential as novel biomarkers and personalized therapy targets. - Source: PubMed
Publication date: 2024/06/06
Wojtera BartoszOstrowska KamilaSzewczyk MateuszMasternak Michał MGolusiński Wojciech - Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. In this context, the identification of biomarkers regarding the PDAC diagnosis, monitoring, and prognosis is crucial. - Source: PubMed
Magouliotis Dimitrios ESakellaridis NikosDimas KonstantinosTasiopoulou Vasiliki SSvokos Konstantina ASvokos Alexis AZacharoulis Dimitris - Five members of the newly identified chloride intracellular channel (CLIC) gene family of intracellular chloride channels (CLIC1-CLIC5) have previously been described in humans. Here we report the molecular cloning and initial characterisation of two splice forms of a novel member of this family, CLIC6, mapping to human chromosome 21. Two essential features distinguish CLIC6 from other members of the family. The CLIC6 protein is significantly longer and the CLIC6 gene contains a GC rich segment, which encodes a 10 amino acid motif repeated 14 times in the amino-terminus. Surprisingly, the repeat is conserved in the lagomorphs, but not in the rodents lineage. The putative bovine orthologue of CLIC5, p64, also exhibits a repeated motif, which is different from that of CLIC6. Attempts to functionally characterise CLIC6 by voltage clamp failed to show any chloride channel activity. Hence, the exact function of this protein remains unknown. - Source: PubMed
Friedli MarcGuipponi MichelBertrand SoniaBertrand DanielNeerman-Arbez MargueriteScott Hamish SAntonarakis Stylianos EReymond Alexandre - Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels. - Source: PubMed
Debska GKicińska ASkalska JSzewczyk A