Ask about this productRelated genes to: CCL15 protein
- Gene:
- CCL15 NIH gene
- Name:
- C-C motif chemokine ligand 15
- Previous symbol:
- SCYA15
- Synonyms:
- HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-02-11
- Date modifiied:
- 2016-03-01
Related products to: CCL15 protein
Related articles to: CCL15 protein
- To analyze the effect of metabolic disorders and immunological parameters on the functional outcome (FO) of acute ischemic stroke (IS) in patients with metabolic syndrome (MS). - Source: PubMed
Tynterova A MBarantsevich E RShusharina N NKhoimov M SRogovskaya M S - Proteomic changes can provide critical insights into the molecular alterations underlying epilepsy. Recent advances in proteomic technologies present opportunities to identify novel biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/02/26
Yao YuanZou QinChen Ke - Oncostatin M (OSM) has been shown to contribute to metabolic dysfunction-associated steatohepatitis (MASH) progression to hepatocellular carcinoma (HCC). Here, we investigated its role in shaping an immunosuppressive tumor microenvironment (TIME) in MASH-HCCs. - Source: PubMed
Publication date: 2026/03/04
Nurcis JessicaFoglia BeatriceRosso ChiaraProvera AlessiaVecchio CristinaMaggiora MarinaGambella AlessandroChianese UgoBocca ClaudiaCaviglia Gian PaoloBenedetti RosariaNovo EricaBossi FrancescaDoto FrancescaKowalik Marta AnnaCaddeo AndreaCarucci PatriziaGaia SilviaRomagnoli RenatoMenconi AlessioTusa IgnaziaRovida ElisabettaPerra AndreaBugianesi ElisabettaAltucci LuciaAlbano EmanueleParola MaurizioSutti SalvatoreCannito Stefania - Lung cancer remains a major cause of cancer-related death, highlighting the need for new molecular targets and novel therapeutics. Matrix metalloproteinases are key regulators of invasion and microenvironment remodeling, and among them, matrix metalloproteinase-12 (MMP12) is a particularly attractive candidate whose network-level effects in cancer are still poorly defined. Herein, we applied an integrative strategy that combines bioinformatics methods with experimental validation in non-small cell lung cancer (NSCLC) cells. Protein-protein interaction (PPI) and pathway analyses of MMP12-regulated genes identified 113 downstream targets enriched in the extracellular matrix, PI3K-AKT, and immune pathways, from which an eight-gene panel (MMP12, CD44, ADAM9, NFKBIA, PSME3, SPARCL1, CCL15, and APOA1) was prioritized as a biomarker signature. Guided by these predictions, we screened a 31-compound MMP12 inhibitor library and selected five leads (, , , , and ) for testing in H1299 cells, with showing the strongest antiproliferative activity. These compounds showed antimigratory activity ( achieving a 90% inhibition of wound closure at its IC concentration), reduced clonogenic growth, cell cycle perturbation, and induction of apoptosis. Gene- and protein-expression analyses confirmed MMP12 suppression and modulation of the eight-gene panel. Upstream regulator predictions implicated reduced AKT signaling alongside an ADAM9-centered adaptive axis. Collectively, these findings highlight , , , , and as promising MMP12 inhibitors, supporting their further development in preclinical lung cancer and nominating the eight-gene panel as a pharmacodynamic signature for MMP12-targeted therapies. - Source: PubMed
Publication date: 2025/12/06
Almutairi ShriefaHajjo RimaSabbah Dima ASweidan KamalRashid Zainab AhmedBardaweel Sanaa K - People of South Asian (SA) origin have an elevated risk of cardiometabolic dysfunction and respond differentially to physical activity. Mechanisms underpinning these observations are incompletely understood. We investigated protein signatures of ethnicity, changing physical activity and their interaction. - Source: PubMed
Publication date: 2025/11/03
Henson JosephGhit AmrTziannou AikaterinaJames EmilyEdwardson Charlotte LBishop Nicolette CRazieh CameronJones Donald J LCao Thong HuyDavies Melanie JKhunti KamleshYates Thomas