Ask about this productRelated genes to: HMOX2 protein
- Gene:
- HMOX2 NIH gene
- Name:
- heme oxygenase 2
- Previous symbol:
- -
- Synonyms:
- HO-2
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-15
- Date modifiied:
- 2017-12-15
Related products to: HMOX2 protein
Related articles to: HMOX2 protein
- Basal blood pressure (BP) is partly determined by systemic vascular resistance, which is modulated by vasoactive pathways, including gaseous messengers. Carbon monoxide (CO), continuously generated by the constitutive enzyme heme oxygenase-2 (HO-2) encoded by , promotes vascular smooth muscle relaxation and may contribute to interindividual variability in resting BP. The functional single-nucleotide polymorphism rs4786504_T>C has been associated with higher expression in C-allele carriers, providing a plausible biological link between genetic variation in the HO-2/CO pathway and vascular redox signaling. We investigated this association in forty young, healthy, normotensive adults studied under controlled laboratory conditions during a 4-day sleep deprivation protocol, with repeated standardized daytime BP measurements (478 observations). Linear mixed-effects models were adjusted for major physiological and behavioral covariates. T-allele carriers (C/T + T/T) exhibited higher diastolic BP (β = +6.08 mmHg, 95%CI [1.32-10.84], = 0.017) and mean arterial pressure (β = +5.28 mmHg, 95%CI [0.28-10.29], = 0.046) than C/C homozygotes, with no effect on systolic BP or heart rate. The association remained consistent across sensitivity and additive genetic models. This hypothesis-generating study provides preliminary evidence in humans, albeit limited by sample size, of a link between a functional variant and resting BP, consistent with a possible contribution of constitutive HO-2 activity to BP regulation. - Source: PubMed
Publication date: 2026/04/21
Beauchamps VincentTouron JulianneGomez-Merino DanielleLagraniere AdrienMalle CarineErkel Marie-ClaireLéger DamienChennaoui MounirSauvet FabienFabries Pierre A - Ischemic heart failure (IHF) is a major cause of cardiovascular morbidity worldwide, characterized by complex tissue remodeling and inflammation. However, reliable molecular biomarkers for early diagnosis and a systematic understanding of the associated immune-stromal microenvironment remain limited. Identifying specific transcriptomic signatures may enhance diagnostic precision and reveal novel therapeutic targets. - Source: PubMed
Publication date: 2026/03/31
Sun YangChang YuFeng YezhiSong BinghuiZhou Yanan - Nanovesicles (NVs)-generated directly from donor cells-have emerged as important mediators of intercellular communication, drug delivery devices, and in therapeutic applications, including regenerative biology. Top-down strategies to enhance the potential regenerative efficacy of NVs following cell hypoxic stress are poorly understood. Here, NVs were generated using rapid extrusion directly from human induced pluripotent stem cells (iPSC) under basal and hypoxic-associated conditions, identifying select pluripotent/stem cell maintenance markers associated with NV composition. We performed adaptive cellular remodeling of iPSC to hypoxic preconditioning over 2, 4, and 6 h, demonstrating that NV form and composition are context-dependent on hypoxia and its duration. Hypoxic exposure modifies the NV temporal protein landscape of networks involved in wound healing (FLNA, MYH9, ACTC1), hypoxia response (HMOX2, HMOX1, PGK), extracellular matrix remodeling (ITGA6, MFGE8, ITGB1), and tissue repair (HSP A5/A8/H1/20/27/70/90, GJA1, HMGB1, ILK). Importantly, we highlight that the NV proteome is dependent and highly consistent on temporal exposure of donor cells to hypoxia, indicating a platform to regulate NV phenotype, tailored toward their potency. Here, we show NVs exhibit a distinct proteome landscape associated with regulation in reactive oxygen species generation and cell/tissue survival (enhanced 2-4 h hypoxia), wound healing and angiogenesis (enhanced 4-6 h hypoxia), and tissue repair, hypoxic response, and metabolic/energy production (enhanced 6 h hypoxia). Extended hypoxic cell exposure (at 4-6 h) regulates NV function in a hypoxic time-dependent manner, with NVs significantly promoting tubule formation of endothelial cells in hypoxic conditions (p < 0.0001). Here, we detailed the capacity of hypoxic cell conditioning to mediate NV phenotype and function in a temporal manner as a platform to enhance functional and potential regenerative therapeutic efficacy of NVs. - Source: PubMed
Publication date: 2026/04/05
Lozano JonathanRai AlinPhang Ren JCross JonathonLim Shiang YGreening David W - Sirtuin 3 (SIRT3), a mitochondrial NAD-dependent deacetylase, plays a central role in regulating mitochondrial metabolism, oxidative stress, and cell survival. Although SIRT3 has been implicated in angiogenesis, apoptosis, and inflammation, its global proteomic impact on the brain remains unclear. This study aimed to systematically characterize alterations in angiogenesis-, apoptosis-, chemokine-, and cytokine-related proteins in the brains of SIRT3 knockout (SIRT3 KO aka SIRT3/) mice compared with wild-type (WT) controls. - Source: PubMed
Publication date: 2026/02/28
He QingpingKhan SamiaWang LinlinIbeanu Gordon CLi P Andy - Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1-OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness. We further identified 15 study-wide significant genetic associations (P < 5.4 × 10) involving eight loci and 14 common bacterial species, of which 11 associations at six loci were replicated. The results confirm previously reported associations at LCT, ABO and FUT2, and provide evidence for new loci MUC12, CORO7-HMOX2, SLC5A11, FOXP1 and FUT3-FUT6, with supporting data from metabolomics and gene expression analyses. Our findings link gut microbial variation genetically to gastrointestinal functions, including enteroendocrine fatty acid sensing, bile composition and mucosal layer composition. - Source: PubMed
Publication date: 2026/02/13
Dekkers Koen FPertiwi KamalitaBaldanzi GabrielLundmark PerHammar UlfMoksnes Marta RiiseCoward EivindNethander MariaSalih Ghassan AliMiari MariamNguyen DiemSayols-Baixeras SergiEklund Aron CHolm Jacob BakNielsen H BjørnVolpiano Camila GazollaMéric GuillaumeThangam ManonanthiniHakaste LiisaTuomi TiinamaijaAhlqvist EmmaSmith Christopher AAllen MarieReimann FrankGribble Fiona MOhlsson ClaesHveem KristianMelander OlleNilsson Peter MEngström GunnarSmith J GustavMichaëlsson KarlÄrnlöv JohanOrho-Melander MarjuFall Tove