Ask about this productRelated genes to: CAPG protein
- Gene:
- CAPG NIH gene
- Name:
- capping actin protein, gelsolin like
- Previous symbol:
- AFCP
- Synonyms:
- MCP
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-14
- Date modifiied:
- 2016-01-18
Related products to: CAPG protein
Related articles to: CAPG protein
- The actin-binding protein CAPG (Capping Actin Protein, Gelsolin Like) is implicated in oncogenesis, but its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study combined bioinformatic analysis of TCGA/GEO datasets, immunohistochemistry on clinical samples, and functional in vitro assays to define CAPG's significance in PDAC. We found CAPG significantly overexpressed in PDAC tissues (n = 179 tumor vs. 171 normal, p < 0.05), with levels correlating with advanced tumor stage (T3 vs. T1) and predicting poorer overall (p = 0.0085) and disease-free (p = 0.015) survival. In vitro, siRNA-mediated CAPG knockdown in PANC-1 and AsPC-1 cells markedly inhibited proliferation (CCK-8 assay) and migration (wound healing assay), and significantly sensitized cells to gemcitabine-induced apoptosis. Mechanistically, CAPG knockdown was associated with reduced ERK1/2 phosphorylation and Cyclin D1 expression, and ERK1/2 inhibition phenocopied the anti-proliferative and chemosensitizing effects. Our results establish CAPG as a negative prognostic biomarker in PDAC, demonstrate its critical role in driving proliferation and migration-potentially via modulating ERK pathway activity-and highlight its promise as a therapeutic target whose inhibition can enhance chemotherapy efficacy. - Source: PubMed
Publication date: 2026/03/31
Qin ZhongyuLi KaixiaLi XuanjieWang HaoruiZhang Yiqiang - Hepatocellular carcinoma (HCC) is characterized by its insidious onset and rapid progression. Investigating diagnostic and therapeutic strategies targeting programmed cell death (PCD) represents a promising research direction. - Source: PubMed
Publication date: 2026/03/06
Lei LixingLiu NianTang LinglingLiu QianqianPan KeHuang Xiaohua - Hepatocellular carcinoma (HCC) is characterized by substantial heterogeneity and immune tolerance, and its therapeutic efficacy is profoundly influenced by the immune microenvironment. Ferroptosis, an iron-dependent form of regulated cell death, is closely linked to tumor immune regulation. We conducted an integrative multi-omics analysis to systematically delineate the composition and function of the ferroptosis-immunity network in HCC. Using TCGA data, we identified ferroptosis-related prognostic genes. By integrating these with immune features via weighted gene co-expression network analysis (WGCNA), we defined 55 ferroptosis-immune microenvironment-related genes (FIMRGs). Single-cell transcriptomic analysis showed that, among immune cell types, macrophages exhibited the highest ferroptosis-immunity activity. Spatial transcriptomics revealed that macrophages with high ferroptosis signaling (FehighMac) preferentially infiltrated tumor nests. These macrophages engaged in robust interactions with T cells via ligand-receptor axes such as ICAM1-ITGAX/ITGB2, TNF-TNFR, and LGALS9-CD45, potentially promoting T-cell exhaustion and shaping an immunosuppressive microenvironment. We identified CAPG-positive macrophages (CAPG + Mac) as the key driver of this process. Characterized by suppressed ferroptosis, enhanced glutathione metabolism, and upregulated immune checkpoints, CAPG + Mac appear to foster an immune-tolerant microenvironment. A prognostic model constructed from CAPG + Mac signature genes effectively stratified HCC patients into high- and low-risk groups and demonstrated stable predictive performance in external validation. This study reveals that CAPG + Mac putatively modulate ferroptosis signaling to influence immune homeostasis, highlighting them as a key target for HCC progression and immunotherapy responsiveness. - Source: PubMed
Publication date: 2026/02/22
Yin XishengLi YantongZheng ShiPan ChunhuiTian ZihanZhong Xiaolin - Explore the causes and mechanisms of bladder cancer-induced Cardiovascular diseases (CVD) death. - Source: PubMed
Publication date: 2026/02/17
Shen JunwenZhao ZhuchengLi ZhaojunWang Rongjiang - Various associations between adipose tissue and atherosclerosis (AS) have been revealed. This study aims to identify biomarkers in the epididymal adipose tissue of AS mice and to explore their effects on adipose tissue inflammation and adipogenesis. - Source: PubMed
Publication date: 2026/02/10
Zhang LuyaoSang BotaoLi SainanLi YingGuo DachuanMa QinanLiu XiangfeiLi XiaoshuoChen BeidongLiu Deping