Ask about this productRelated genes to: TBCA protein
- Gene:
- TBCA NIH gene
- Name:
- tubulin folding cofactor A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-31
- Date modifiied:
- 2015-08-26
Related products to: TBCA protein
Related articles to: TBCA protein
- Senescence, a key aging mechanism, is linked to disease via the senescence-associated secretory phenotype (SASP), yet its role in dementia remains unclear. We aimed to identify a minimal circulating SASP protein panel to predict incident dementia and identify causally-associated proteins. Among midlife and late-life participants from the Atherosclerosis Risk in Communities (ARIC) study, we developed three weighted SASP protein scores via multivariable Cox proportional hazards or Lasso Cox regression. Cox proportional hazards regression estimated associations between each standardized score (mean = 0; SD = 1) and incident dementia in an independent ARIC sample and validated in the Multi-Ethnic Study of Atherosclerosis (MESA). Mendelian randomization analyses evaluated causal relationships between SASP proteins and dementia risk. Comparable significant associations were observed across scores in ARIC (per 1 SD: HRs: midlife 1.20-1.33; late-life 1.39-1.50) and MESA (midlife: 1.28-1.38; late-life 1.40-1.62), with stronger associations for late-life scores. Tubulin folding cofactor A protein was the only protein causally associated with incident dementia. SASP scores, even with few proteins, are useful dementia biomarkers, and TBCA is a promising therapeutic target. - Source: PubMed
Publication date: 2026/03/26
Prizment AnnaPark SaeunRao ZexiWang ShuoLutsey Pamela LPankow JimSullivan Shannon MTang WeihongSabayan BehnamHughes Timothy MWalker Keenan ADubin RuthDeo RajatPost WendyRotter Jerome IWood Alexis CGanz PeterGuan WeihuaSedaghat Sanaz - There is growing evidence linking the consumption of ultra-processed foods (UPFs) to adverse health outcomes. Accurate classification of foods according to the extent and purpose of industrial processing is therefore essential for improving dietary assessment and public health strategies. This study aimed to evaluate and compare the performance of two large language models (LLMs), DeepSeek-R1 and ChatGPT o1, in classifying foods according to the NOVA classification system. - Source: PubMed
Publication date: 2025/12/11
Cattem Marcus Vinicius de OliveiraMachado Felipe Olasagastida Silva Maria Eduarda GuerreiroCanella Daniela SilvaKoury Josely Correa - Identifying spatially resolved proteomes has advanced markedly, yet integrating definitive protein identification with precise spatial localization in a single workflow remains challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables antibody-free mapping of proteins in tissue sections, but its capacity for unambiguous identification is limited. Here, we present a combined MALDI-MSI and liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach to map protein localization and track spatial changes in murine thymus during chemotherapy-induced involution and regeneration. Our workflow incorporates a scoring algorithm (pepBridge) that aligns MALDI-MSI molecular signals with LC-MS/MS identifications, enabling confident assignment of proteins, critical to thymic function. Using this pipeline, we reveal spatiotemporal changes in proteins involved in cell migration, cytoskeletal remodeling, and thymic regeneration. Notably, we identify distinct spatial shifts in nucleoprotein TPR and tubulin-associated chaperone A (TBCA), corresponding to chemotherapy-driven architectural remodeling. Translationally, these findings highlight pathways and targets to promote immune recovery in pediatric cancer patients undergoing cytoreductive therapy. Analytically, this framework advances spatial proteomics by enabling high-confidence protein identification in lymphoid tissues, broadening the potential of translational proteomic research. - Source: PubMed
Publication date: 2025/11/20
Aguilan Jennifer TMadrid-Aliste CarlosFischer JoshuaLagou Maria KSidoli SimoneKaragiannis George S - Reliable biomarkers that assist in the diagnosis of autism spectrum disorder (ASD) are limited. This study aimed to identify proteins that can differentiate children with ASD from controls. - Source: PubMed
Publication date: 2025/09/13
Lee TaeyeopYu JiyoungAhn Hee SungYeom JeonghunHyun YerinKim Ju YeonHong JeongyeonYoo Jung-YoonKim KyunggonKim Hyo-Won - BACKGROUNDOptimal TB care and control requires improved health education and effective patient counselling. Effective counselling is a lengthy process that requires addressing all questions related to TB transmission, risk, the disease process, prevention, diagnosis, and treatment. We evaluated the quality of artificial intelligence (AI) chatbot responses, compared to global expert opinion.METHODSWe configured an AI chatbot (TB counselling assistant [TBCA]) based on GPT-4. It was designed to draw information from reputable TB guidelines and tasked to provide educational responses. We tested the TBCA on 39 questions frequently asked by people with TB and their caregivers. Responses were appraised for quality by global TB experts using a modified Delphi consensus approach.RESULTSNinety-four experts were invited to participate, of whom 91 (96.8%) participated. Overall, the TBCA provided accurate answers to questions in all relevant domains, including epidemiology, clinical presentation, prevention, diagnosis, and treatment, as well as special considerations in vulnerable populations, while citing its information sources. When appropriate, it consistently directed the individual to seek advice from an appropriate health care provider. At times, the information provided was out of date (e.g., the definition of multidrug-resistant TB). It also struggled to distinguish diagnostic tests for TB infection and disease.CONCLUSIONLarge language models can provide accurate responses to general TB questions, but the information provided may be out of date, or lack context. Although the advice provided was generally safe and helpful, health care professionals remain crucial to ensure advice is up to date and appropriate to the individual's unique circumstances.. - Source: PubMed
Ngiam J NKoh M C YD'Ambrosio LGoletti DDenholm J TAkkerman O WCentis RDinh-Xuan A TPontali ETorrico M MGarcia-Basteiro A LSchaaf H SMigliori G BOng C W M