Ask about this productRelated genes to: IL18 protein
- Gene:
- IL18 NIH gene
- Name:
- interleukin 18
- Previous symbol:
- -
- Synonyms:
- IGIF, IL1F4, IL-1g, IL-18
- Chromosome:
- 11q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2015-07-06
- Gene:
- IL18BP NIH gene
- Name:
- interleukin 18 binding protein
- Previous symbol:
- -
- Synonyms:
- IL18BPa
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-21
- Date modifiied:
- 2016-10-05
Related products to: IL18 protein
Related articles to: IL18 protein
- Interleukin-18 (IL-18) is a promising cytokine for immunotherapy. Besides exploiting the cytokine itself or mutant versions thereof for biomedical applications, bi- and multispecific antibody scaffolds can be harnessed that mimic the function of IL-18 by triggering receptor signaling. In addition to potential advantages with respect of manufacturability, a major benefit in using bispecific antibody derivatives relies in the different structure and sequence of the antibody compared to the cytokine. The activity of IL-18 is normally regulated in a negative feedback loop via IL-18 binding protein (IL-18BP) that binds with high affinities to IL-18 and prevents IL-18 from binding to its receptor. This physiological process is hijacked in certain types of cancer. We have generated VHH-derived bispecific surrogate agonists that are naturally resistant to inhibition by the decoy receptor IL-18BP. In this chapter, we detail protocols about the generation and characterization of IL-18 mimicking bispecifics. - Source: PubMed
Lipinski BrittaElter DesislavaArras PaulUnmuth LauraKrah SimonDoerner AchimEvers AndreasPekar LukasZielonka Stefan - Interleukin-18 (IL-18) is a member of the IL-1 cytokine family with significant homology to IL-1β. New emerging evidence indicates that IL-18 acts as a pivotal molecular bridge connecting innate and adaptive immunity, functioning through tightly regulated mechanisms involving inflammasome-dependent and -independent proteolytic processing. The activity of IL-18 is primarily maintained by IL-18 binding protein (IL-18BP), which neutralizes IL-18 under physiological conditions. However, dysregulations in the IL-18/IL-18BP axis result in excessive IL-18 bioactivity, driving tissue inflammation and damage closely associated with autoimmune pathogenesis. Herein, we review recent advances in IL-18 biology and its expanding roles in the development of various autoimmune diseases. The molecular mechanisms by which IL-18 mediates organ-specific pathology are discussed to highlight its diverse effector functions across different autoimmune conditions. In addition, we evaluate emerging therapeutic approaches targeting the IL-18 pathway, with a focus on their potential and challenges in translational clinical research. - Source: PubMed
Publication date: 2026/03/16
Zhao YueTang YuanZhu XiaoxiaHou YunxiaLi HongbinCiccia FrancescoZou HejianLu Liwei - Mevalonate kinase deficiency (MKD) is a rare monogenic autoinflammatory disorder characterized by recurrent fever episodes driven by dysregulated IL-1β secretion. Mutations in the MVK gene cause enzymatic defects resulting in a shortage of geranylgeranyl pyrophosphate, leading to a lowering of the threshold for pyrin inflammasome activation. - Source: PubMed
Publication date: 2026/03/09
van Heusden Niels SCuijpers IsaMeijer NilsPieren DaanMarkovska AngelaGabay CemGirard CharlotteKoné-Paut IsabelleVastert BasHamann DörteJans JudithVan Nieuwenhove ErikaFrenkel JoostBoes Marianne - Immune response evasion is one of the hallmark features of cancer, which is not only the basis for cancer progression and metastasis but also affects the clinical management of cancer. Tumor immune evasion is mainly attributed to the dynamic and immunosuppressive tumor microenvironment (TME), which is regulated by a complex system including immunosuppressive cells and cytokines. Interleukin-18 (IL-18) is an important cytokine that plays a multifaceted role in immune system regulation, and its function is strictly regulated by the natural antagonist IL-18 binding protein (IL-18BP). IL-18 exhibits context-dependent immunoregulatory characteristics (acting as a "context resistor") during tumor occurrence and progression, which is closely related to cancer type, stage, and the signaling network of the tumor microenvironment. The multifaceted functions of IL-18 have been utilized in cancer treatment to reduce the phenomenon of immune escape of tumors. With the latest advancements in cancer research related to IL-18, it is necessary to integrate the latest research findings to deepen the understanding of the mechanism of tumor immune escape and promote the improvement of cancer treatment levels. This review will systematically elaborate on the action mode, core regulatory mechanism and key signaling pathways of IL-18 in tumor immune evasion, analyze the heterogeneity patterns associated with its context-dependent effects, comprehensively sort out the core obstacles in clinical translation, and at the same time, envision new precision treatment strategies based on IL-18 regulation. - Source: PubMed
Publication date: 2026/02/12
Li ShuaiGao ChenxiaZhao HongyuWang DidiLiu Shuang - Systemic juvenile idiopathic arthritis (sJIA) is a pediatric-onset autoinflammatory disease that may progress to fatal macrophage activation syndrome (MAS). Free interleukin-18 (IL-18), which is unbound to IL-18 binding protein (IL-18BP), may reflect its biological activity, but its accurate measurement remains challenging and its clinical usefulness in sJIA remains unclear. - Source: PubMed
Publication date: 2026/02/23
Miwa YukiKawamoto NorioMiwa TakaoHaba AzusaKadowaki SaoriShiraki MayukaKamatari Yuji OOhnishi Hidenori