Ask about this productRelated genes to: KIR2DS4 protein
- Gene:
- KIR2DS4 NIH gene
- Name:
- killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4
- Previous symbol:
- -
- Synonyms:
- cl-39, KKA3, nkat8, CD158i
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-01-20
Related products to: KIR2DS4 protein
Related articles to: KIR2DS4 protein
- To identify druggable genes associated with cataract and investigate their functional roles under oxidative stress, thereby providing potential therapeutic targets. - Source: PubMed
Publication date: 2026/04/16
Lin MinZeng Jie - Although IFI44 is recognized for its crucial role in autoimmune disorders, its function in breast cancer (BC) remains unclear. This study aimed to investigate the immune-related and prognostic significance of IFI44 in BC. - Source: PubMed
Publication date: 2026/04/08
Wu JiahuiYi WangLiu MengtingLi YingliangZhou BoxuanWu ZiyunCao WeiShi QingfengCai XiangkaiXiong Haiwei - The killer-cell immunoglobulin-like receptor () gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism. To date, 2,286 distinct alleles have been released in the IPD-KIR Database. However, little is known about the impact of high-resolution-level allelic polymorphisms on leukemia. Our previous study showed that the genotype carrying more inhibitory genes conferred differential protection against leukemia in the Chinese Southern Han population. Herein, we hypothesized the impact of alleles in the haplotype and cognate human leukocyte antigen (HLA) ligand on leukemia. - Source: PubMed
Publication date: 2026/02/05
Deng ZhihuiZhen JianxinLi YunanLiang ShuangZhang ManruCai SiqiJiang RenhuiYang ZhichaoYu QiongWang JinyongLiu Jie - Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation. - Source: PubMed
Publication date: 2025/11/13
Wang QiongKuang QingChen ChengWang BinruXiang WeiLi XinmingMou Jianjiao - Genotyping of killer cell immunoglobulin-like receptors (KIR) of NK-cells was performed in 634 women with early pregnancy losses (EPL), including 158 women with recurrent implantation failure (RIF) after at least three IVF cycles, and 110 women with at least two intrauterine pregnancy losses characterized by clinically confirmed retention of a non-viable fetus in the uterus without spontaneous miscarriage, defined as recurrent pregnancy loss (RPL). The control group consisted of 431 women with at least two healthy children. In the RIF, a significant shift in the frequency of KIR-genotypes was observed compared with both the control and the RPL groups. A significantly higher frequency of the KIR-AA genotype was observed in the RIF group compared to the control group (χ² = 26.78; p < 0.0001; OR = 2.7) and the RPL group (χ² = 15.83; p < 0.0001; OR = 2.86). Analysis of the frequency of full-length/deletion alleles of KIR2DS4 among AA genotype carriers showed an increased frequency of the 2DS4-del in the RIF compared with the RPL and control groups. A significantly higher frequency of the cenAA was also observed in RIF compared with the control (χ² = 20.10; p < 0.0001) and the RPL(χ² = 12.05; p < 0.005). The significantly increased frequency of the KIR-AA genotype with predominance of deletion KIR2DS4 alleles, along with the elevated frequency of the cenAA in RIF, may indicate insufficient NK-cell activation at the stage of embryo implantation. These findings suggest different etiological mechanisms for RIF and RPL. - Source: PubMed
Publication date: 2025/10/16
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