Ask about this productRelated genes to: KIR2DL1 protein
- Gene:
- KIR2DL1 NIH gene
- Name:
- killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
- Previous symbol:
- -
- Synonyms:
- cl-42, nkat1, 47.11, p58.1, CD158A
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-11-09
Related products to: KIR2DL1 protein
Related articles to: KIR2DL1 protein
- The Novel KIR3DL1*0010123, KIR3DL1*0010124, KIR2DL1*0010108, KIR2DL1*0010109 alleles were identified in healthy individuals from the Indian Population. - Source: PubMed
Sharma GauravAgarwal DishaKhadwal AlkaDas ReenaMalhotra Pankaj - The killer-cell immunoglobulin-like receptor () gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism. To date, 2,286 distinct alleles have been released in the IPD-KIR Database. However, little is known about the impact of high-resolution-level allelic polymorphisms on leukemia. Our previous study showed that the genotype carrying more inhibitory genes conferred differential protection against leukemia in the Chinese Southern Han population. Herein, we hypothesized the impact of alleles in the haplotype and cognate human leukocyte antigen (HLA) ligand on leukemia. - Source: PubMed
Publication date: 2026/02/05
Deng ZhihuiZhen JianxinLi YunanLiang ShuangZhang ManruCai SiqiJiang RenhuiYang ZhichaoYu QiongWang JinyongLiu Jie - Broadly neutralizing antibodies (bnAbs) are evaluated as possible alternatives to standard antiretroviral treatment (ART) for maintaining control of HIV-1 replication and may enhance immune responses to reduce or control the viral reservoir. However, the immunological and virological effects of bnAbs in infants and children are unknown. We conducted a detailed analysis of proviral reservoir dynamics and antiviral immune responses in a unique group of young children from Botswana who started ART at birth and then stopped standard ART while receiving the bnAbs 10-1074 and VRC01-LS in a subsequent clinical trial. No quantitative changes in frequencies of proviral sequences were observed during bnAb treatment, but selection of genome-intact proviruses in transcriptionally repressive heterochromatin regions occurred in some study participants. Faster viral rebound following standard ART cessation was linked to elevated proportions of KIR2DL1-positive NK cells. In contrast, delayed viral rebound and more limited viral reservoir size were associated with elevated proportions of NKG2A-positive NK cells and with the HLA-B-21M signal peptide polymorphism. HIV-specific T cell responses were low in all study participants and unrelated to viral reservoir sizes or clinical outcomes following ART interruption. These results suggest that, in young children, specific NK cell subsets and KIR-HLA interactions might be linked to HIV-1 rebound kinetics after substitution of standard ART with bnAbs. - Source: PubMed
Publication date: 2026/02/16
Niesar AischaLancien MelanieHong SeohyunNaasz ChloeAjibola GbolahanMaswabi KennethSakoi-Mosetlhi MaureenBatlang OganneMoyo SikhulileMohammed TerenceMaphorisa ComfortCarrere LeahRoseto IsabelleHartana Ciputra AdijayaTan Toong SengGao CeParsons ElizabethHua ReneePretorius Holme MollyLockman ShahinPowis Kathleen MCarrington MaryMakhema JosephYu Xu GKuritzkes Daniel RShapiro Roger LLichterfeld Mathias - Gamma delta (γδ) T cells are important mediators of the immune response to childhood malaria. Human Vγ9+Vδ2+ T cells possess intrinsic, HLA-independent responsiveness to Plasmodium falciparum phosphoantigens produced in the blood stage of malaria. Engagement of the γδ T cell receptor (TCR) by phosphoantigen-bound butyrophilin molecules results in Vγ9+Vδ2+ T cell expansion, pro-inflammatory cytokine production, and release of cytotoxic granules that mediate parasite killing. Repeated P. falciparum infection, however, leads to a reduction in circulating Vγ9+Vδ2+ T cells and upregulation of immunomodulatory molecules, including NK receptors, that correlates with less severe symptoms upon infection. We explore phenotypic and functional differences of γδ T cells in Ugandan children with high versus low malaria exposure, utilizing high-parameter spectral flow cytometry analysis of PBMCs. We observed significant differences in expression of inhibitory NK receptors - KIR2DL1, KIR2DL2/3, KIR3DL1, LILRB1, and NKG2A - on γδ T cell subsets, with Vγ9+Vδ2+ T cells exhibiting a divergent mechanism of control compared to other subsets. We found that NKG2A and KIR3DL1 expression associated with potent Vγ9+Vδ2+ T cell responses to TCR- and Fc receptor (FcR)-mediated stimulation while KIR2DL1, KIR2DL2/3 and LILRB1 associated with reduced degranulation and cytokine production. These results identify a new role for inhibitory NK receptors expressed on γδ T cells, exerting a finely tuned balance of activating and inhibitory signals to regulate the response to malaria-related antigens. - Source: PubMed
Publication date: 2026/02/03
Olive Meagan ECallaway Perri CIlala MikiasLevan JustineAcevedo Gonzalo RNankya FelistasArinaitwe EmmanuelRek JohnJagannathan PrasannaDorsey GrantKamya Moses RFeeney Margaret E - Natural killer (NK) cells are lymphocytes of the innate immunity and sense healthy or diseased target cells with activating and inhibitory NK cell receptor (NKR) molecules expressed on the cell surface. The protection provided by NK cells against viral infections and tumors critically depends on their ability to distinguish healthy cells from diseased target cells that express 100-fold more activating ligands. NK cell signaling and activation depend on integrating opposing signals initiated by activating and inhibitory NKRs interacting with the cognate ligands expressed on target cells. Imaging experiments show that both activating and inhibitory NKRs in the plasma membrane form submicron-sized clusters in resting NK cells. How do these submicron-sized NKR clusters formed in the resting state affect signal discrimination? Using in-silico mechanistic signaling modeling combined with information theory and published super-resolution imaging data for two well-studied human NKRs, activating NKG2D and inhibitory KIR2DL1, we show that early-time signal discrimination by NK cells depends on the spatial statistics of these clusters. Modeling shows when NKG2D and KIR2DL1 clusters are disjoint in the resting state, these clusters help NK cells to discriminate between target cells expressing low and high levels of the activating cognate ligand, whereas when the NKR clusters show high degree of overlap, this prevents NK cells from differentiating healthy from diseased target cells. Therefore, the spatial statistics of submicron-scale clusters of activating and inhibitory NKRs at the resting state provide an additional layer of control for signal discrimination in NK cells. - Source: PubMed
Publication date: 2026/01/14
Ahmad SaeedMukhopadhyay DebanganaGrewal Rajdeep KaurJayaprakash CiriyamDas Jayajit