Ask about this productRelated genes to: GroEL protein
- Gene:
- HSPD1 NIH gene
- Name:
- heat shock protein family D (Hsp60) member 1
- Previous symbol:
- SPG13
- Synonyms:
- GroEL, HSP60
- Chromosome:
- 2q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-19
- Date modifiied:
- 2015-11-19
Related products to: GroEL protein
Related articles to: GroEL protein
- Mitophagy plays a critical role in the pathology of Parkinson's disease (PD) via mitochondrial quality control, making it a promising therapeutic target. However, the precise mechanistic role of mitophagy in PD pathogenesis and progression remains unclear. - Source: PubMed
Publication date: 2026/04/17
Li XuesongZhang YujiaYang QianwenGong JunweiZhang NingningHuang YifanChen TaoZhou DiZou ZhaoGuo Zongduo - Chemoresistance is a major challenge in lung adenocarcinoma (LUAD) treatment and is associated with mitochondrial metabolism. Using publicly available LUAD transcriptome data, we established a five-gene prognostic signature (, , , , and ) for LUAD through differential gene expression profiling, univariate Cox analysis, and machine learning-based feature selection. Patients with LUAD were classified into a high-risk group (HRG) and a low-risk group (LRG) based on their risk scores. Enrichment analysis revealed significant differences between the HRG and LRG in multiple pathways related to metabolism and immunity. The immune microenvironment also differed significantly between the two groups, and the prognostic genes were correlated with infiltrating immune cells. A total of 110 compounds exhibited differential sensitivity across the groups. Molecular docking demonstrated a favorable binding affinity between the prognostic genes and the predicted drugs. Furthermore, knockdown significantly suppressed cancer cell proliferation in cell and animal models. In addition, knockdown markedly reduced cisplatin resistance by downregulating key regulators of the DNA replication and repair pathway, including and . These results provide insight into the molecular mechanisms underlying chemoresistance and identify putative therapeutic targets for LUAD treatment. - Source: PubMed
Publication date: 2026/03/27
Tan BinbinYang JinxuZhao XibaoLiu Shanshan - Chemoresistance to cisplatin is a major contributor to the progression of head and neck squamous cell carcinoma (HNSCC); however, the mechanisms underlying cisplatin resistance in HNSCC remain incompletely understood. Dysregulation of metabolite transport between mitochondria and the cytoplasm, mediated by solute carrier family 25 (SLC25), is closely associated with tumor progression. Solute carrier family 25 member 1 (SLC25A1) promotes malignant phenotypes in various cancers; however, its role in HNSCC remains unexplored. Here, we demonstrate that SLC25A1 is overexpressed in HNSCC and is closely associated with poor prognosis. SLC25A1 upregulation promotes cisplatin resistance in HNSCC cells. Moreover, SLC25A1 enhances cisplatin resistance in HNSCC cells by inducing cellular senescence. Mechanistically, SLC25A1 upregulates the expression of RANBP1, CDC45, and PES1 through histone H3 lysine 27 acetylation-mediated transcriptional activation. Furthermore, SLC25A1 interacts with HSPD1, a mitochondrial chaperonin protein, via its C-terminal region to increase citrate transport and cytosolic acetyl-CoA levels. Treatment with CTPI-2, a specific inhibitor of SLC25A1, exhibits therapeutic effects against cisplatin-resistant HNSCC. These findings establish SLC25A1 as a key regulator of cisplatin resistance in HNSCC, suggesting that it serves as both a predictive biomarker and a potential therapeutic target in chemoresistant HNSCC. From a translational perspective, these results support CTPI-2 as a promising therapeutic agent for overcoming cisplatin resistance. - Source: PubMed
Publication date: 2026/04/10
Li JingYang TaoLi YunYang XinjieHe YaodongYao YanbingZhao ShengnanLiu RongYang ZihuiZhang HongxinWang QianLi HuanWei Jianhua - Intracerebral hemorrhage (ICH) triggers a profound neuroinflammatory cascade in which microglial polarization critically influences secondary brain injury and neurological outcomes. Clinical data revealed that Hspd1 expression is significantly elevated in circulating monocytes from ICH patients and negatively correlates with functional recovery, implicating Hspd1 in disease progression. - Source: PubMed
Publication date: 2026/03/30
Gao LuXia LiCheng Bao ChunWang XueyiLi GenYe LeiJi XuefeiWang HuiLi ZhongyingWang CunzhiRen ZhenhuaYin Ling - This study systematically evaluated the hepatotoxic potential of common microplastic monomers using ADMETlab 3.0, identifying styrene (PubChem ID: 7501) as exhibiting significant hepatic toxicity. Comprehensive analysis of the CTD (Comparative Toxicogenomics Database) revealed a strong association between styrene exposure and NAFLD (Non-alcoholic fatty liver disease). We integrated target prediction data from CTD, STITCH and SwissTargetPrediction databases yielding 558 candidate targets, which were cross-referenced with 2018 NAFLD related genes from GeneCards and OMIM to identify 158 overlapping genes. Applying the NCBI GEO datasets GSE48452, GSE126848, GSE89632, and GSE63067, comprising 98 control samples and 113 NAFLD samples, we trained the model using LASSO regression, random forest, and SVM-RFE algorithms to identify the core genes HSPD1 and NFE2L2. These findings were validated in the GSE135251 cohort, which included 10 control cases and 206 NAFLD cases. In vitro experiments showed 100 nm polystyrene nanoparticles (PS-NPs) at 200 μg/mL for HepG2 and 100 μg/mL for AML12 cells significantly increased lipid accumulation by Oil Red O staining. Western blot revealed dose-dependent changes in lipid metabolism regulators ACC1, FASN and CPT1A. Preliminary RT-qPCR and immunofluorescence studies indicate that PS-NPs can upregulate HSPD1 and NFE2L2. These findings suggest that PS-NPs promote hepatic lipid accumulation by regulating HSPD1 and NFE2L2, offering new insights into the pathogenesis of environmentally induced NAFLD. - Source: PubMed
Publication date: 2026/03/28
Zhang YiqiongShi YachunYang HuiruLi HaizhiLi ChengchengLiu MiZhong YinxueHuang ChangyudongZhu LiyingXu YongjiePan Wei