Ask about this productRelated genes to: NQO2 antibody
- Gene:
- NQO2 NIH gene
- Name:
- N-ribosyldihydronicotinamide:quinone reductase 2
- Previous symbol:
- NMOR2
- Synonyms:
- QR2, DHQV, DIA6
- Chromosome:
- 6p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-13
- Date modifiied:
- 2017-01-27
Related products to: NQO2 antibody
Related articles to: NQO2 antibody
- Proteasome inhibitors (PIs) are frontline therapies for multiple myeloma (MM). Although MM patients initially respond to PIs, resistance frequently emerges. While all PIs nominally target the same proteasomal catalytic subunit (PSMB5), the extent to which resistance mechanisms are the same or different among different PIs or between patients is poorly understood. To address this, we performed proteome and phosphoproteome profiling of 12 MM cell line models, comprising four parental lines (AMO-1, ARH77, L363, and RPMI8226) paired with lines that acquired resistance to bortezomib (BTZ) or carfilzomib (CFZ). Over 7,000 proteins and up to 10,000 phosphopeptides were identified per cell line, enabling a comprehensive comparative analysis of shared and cell line-specific resistance signatures at the protein level. Data analysis revealed surprisingly few changes in the phosphoproteome but substantial reprogramming of the proteome in most models. Beyond known adaptations such as the overexpression of the PI target PSMB5 and the drug efflux transporter ABCB1, we identified the oxidoreductases NQO1 and NQO2 as significantly upregulated proteins under chronic proteotoxic stress across several models. Pharmacological follow up in PI resistant AMO-1 cells showed that NQO2 inhibition by imatinib fully restored CFZ sensitivity, validating NQO2 as a contributor to resistance formation in this model system. - Source: PubMed
Publication date: 2026/06/26
Lee Chien-YunHan SeungbinHaertle LarissaMunawar UmairVogt CorneliaStreubel JohannaBesse AndrejBesse LenkaDriessen ChristophEinsele HermannWaldschmidt JohannesKortüm MartinKuster Bernhard - Osteoarthritis is the predominant joint ailment. Multiple studies demonstrate that the dysregulation of catalytic regulators of ubiquitination and deubiquitination disrupts cartilage imbalance, consequently facilitating the advancement of osteoarthritis. - Source: PubMed
Publication date: 2026/06/12
Yin HongboMei YuzhenDu JuanXiao LangBian Songbo - The design of new molecules from known structural motifs [3 + 2] cycloaddition is a widely used strategy in modern drug discovery. Herein, an efficient, eco-friendly synthesis of spiroindeno- and spirooxindolo-pyrrolizidine derivatives is reported using triclocarban as an organocatalyst in ethanol, affording 80-96% of yields within 1.4 h with excellent regioselectivity. The synthesized compounds were evaluated for cytotoxicity against human cancer cell lines and normal HEK-293 cells. Among them, compound 6b exhibited significant antiproliferative activity against MCF-7 cells (IC = 4.23 ± 0.54 μM), while none of the compounds showed toxicity toward normal cells. Biological investigations suggest that compound 6b induces apoptosis, which is potentially associated with mitochondrial membrane depolarization, ROS generation, DNA damage, nuclear morphological changes and inhibition of cell migration. Molecular docking and dynamics simulations suggested stable binding of compound 6b to NQO2, while ADMET analysis indicated favourable pharmacokinetic properties. - Source: PubMed
Publication date: 2026/04/22
Rukyanaik VPradhan SamataGodugu ChandraiahTothadi SrinuKrishna Kadiyam RamaPawar RavinderBasavoju Srinivas - Persistently infected (PI) calves resulting from maternal Bovine viral diarrhea virus (BVDV) infection during early gestation are the main source of viral transmission and pose a serious threat to the sustainable production of herds. PI cattle appear clinically normal, elucidating the molecular-level alterations is critical for understanding their specific characteristics. Moreover, the identification of candidate biomarkers for diagnosing PI cattle will provide valuable insights to support effective strategies for the control and eventual eradication of BVDV. At the same time, few studies have focused on the mothers of PI calves (Trojan dam). - Source: PubMed
Publication date: 2026/03/10
Wang JiahaoChen SiqianLai WanyiFeng XiaoZhao QingyaoMi SiyuanXu ChuangQin TongCao JieYu Ying - This study investigates the relationship between NQO1 and NQO2 gene polymorphisms and methamphetamine-associated psychosis (MAP) in the Makassar population. - Source: PubMed
Publication date: 2026/02/01
Ludong Dani HaryantoSupartını TriIsmaıl Ismail