Ask about this productRelated genes to: Axin1 antibody
- Gene:
- AXIN1 NIH gene
- Name:
- axin 1
- Previous symbol:
- -
- Synonyms:
- PPP1R49
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2015-08-24
Related products to: Axin1 antibody
Related articles to: Axin1 antibody
- . Pancreatic ductal adenocarcinoma remains difficult to treat and has an exceptionally poor prognosis. While prior studies have noted antitumour properties for midazolam in pancreatic cancer, whether this response involves developmental signaling pathways is unclear. Here, we evaluated midazolam-treated MIA PaCa-2 cells to identify associated Wnt and Hedgehog transcriptional shifts and their systems-level context. . MIA PaCa-2 cells were exposed to midazolam (20-100 µM) for 24 h. We measured metabolic viability by MTT and apoptosis by Annexin V-FITC/7-AAD flow cytometry at 60 µM. Expression of 18 targeted genes was quantified by RT-qPCR using ACTB for normalization. Changed genes were examined through STRING/KEGG networks, TCGA-PAAD survival analysis, DGIdb annotations, and preliminary FZD7 molecular docking. . Midazolam reduced MTT-derived metabolic viability in a concentration-dependent manner (IC = 54.6 µM) and significantly increased Annexin V-positive apoptotic populations at 60 µM across three independent experiments. Eight transcripts changed significantly: CTNNB1, TGFBR2, WNT2, WNT7B, HHIP, and DHH declined, while CSNK1A1 and AXIN1 increased (all adjusted < 0.05). Network analysis highlighted CTNNB1 as the main hub, and high CTNNB1 expression correlated with shorter survival in TCGA-PAAD patients ( = 0.043; HR = 1.58, 95% CI: 1.01-2.47). . Midazolam reduced metabolic viability and increased apoptosis in MIA PaCa-2 cells alongside coordinated expression changes in key Wnt and Hedgehog components. Because the required doses far exceed clinical sedation levels and pathway activity was not directly confirmed at the protein level, these findings should be regarded as a preliminary hypothesis rather than evidence of therapeutic efficacy. - Source: PubMed
Publication date: 2026/09/17
Korkmaz Irmak FatoşElgun TugbaAktas CiğdemEslamkhah SajjadSevinc Sevgi KocyigitYurttas Asiye Gok - /Aims: Hepatocellular carcinoma (HCC) is an aggressive disease with limited response to available therapies. Progress in therapeutic development has been hampered by the lack of preclinical models that recapitulate human HCC and support evaluation of multimodal therapies. Here, we employ CRISPR editing to identify alterations that drive hepatocyte transformation and to establish genetically defined HCC models. - Source: PubMed
Publication date: 2026/09/22
Elkhadragy LobnaDavid Olayinka GCastillo Caitlyn CRedlon Luke NJordan Luke RKhan NusratLiu HannahRosa Lopes Isadora AndreZhou YanqiongKanzaki HiroakiHoshida YujinSamuelson Jonathan PLujambio AmaiaSchook Lawrence BGuzman GraceSchachtschneider Kyle MGaba Ron C - is a major human pathogen that can elicit immune-inflammatory responses and infections, largely driven by its broad repertoire of antigenic proteins. Understanding these factors is valuable for elucidating mechanisms of infection. - Source: PubMed
Publication date: 2026/09/02
Dalloul Rajaa S DSohail Muhammad UChennakkandathil SareenaSawarth HinaAl-Noubi MunaChoi SunkyuSchmidt Frank - Water extract of Semiliquidambar cathayensis (WESC) exhibits favorable therapeutic effects against depression, yet its pharmacodynamic material basis and mechanism of action remain unclear. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was employed to analyze the chemical constituents of WESC. Network pharmacology and molecular docking were further applied to screen the antidepressant mechanism basis and potential targets of WESC. Lipopolysaccharide (LPS)-induced mouse and PC12 cell models were established as in vivo depressive animal model and in vitro cellular injury model, respectively. Combined with pathological examination and molecular biological techniques, the antidepressant mechanism of WESC was systematically investigated. Results showed that a total of 14 chemical components were identified from WESC. Network pharmacology and molecular docking analyses indicated that GSK3β was one of the key targets, and the active components in WESC possessed strong binding affinities with GSK3β, Axin1, and NF-κB. Pathological studies demonstrated that WESC significantly alleviated inflammatory infiltration in the mouse prefrontal cortex and hippocampal neuronal damage. Molecular biological analyses revealed that WESC markedly downregulated the expression of proteins related to the GSK3β/NF-κB signaling pathway in LPS-stimulated mice and PC12 cells, thereby attenuating neuroinflammation, promoting neural plasticity, and exerting antidepressant effects. - Source: PubMed
Yang LiHe JunhuiLi DongmeiLi YiSu QibiaoLiang HongningYuan JiantongLai KedaoWei Guining - The Ordos fine-wool sheep is a high-quality fine-wool breed in China, renowned for its excellent wool quality, meat production, and adaptability to the arid and semi-arid regions of Inner Mongolia. Body weight and wool traits are important economic characteristics in sheep breeding. This study aimed to identify genetic loci associated with body weight (BW), wool length (WL), and wool fineness (WF) in Ordos fine-wool sheep. - Source: PubMed
Publication date: 2026/08/28
Zhang LifeiGu YingHe XiaolongWang BiaoDa LaiDe DemaTe RigeleLiu YongbinFu Shaoyin