Ask about this productRelated genes to: G6PD antibody
- Gene:
- G6PD NIH gene
- Name:
- glucose-6-phosphate dehydrogenase
- Previous symbol:
- -
- Synonyms:
- G6PD1
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: G6PD antibody
Related articles to: G6PD antibody
- Breast cancer exhibits high heterogeneity and drug resistance, presenting severe challenges in clinical treatment. - Source: PubMed
Publication date: 2026/05/08
Ye XuqinShao Gang - The present study aimed to investigate the protective effects of astaxanthin (AST) and melatonin (MLT) on ram sperm quality-associated indicators during cryopreservation, and to explore the molecular effects of the two cryoprotectants on the protein profile of cryopreserved sperm. First, ram sperm were diluted with freezing media supplemented with different concentrations of AST and MLT, and then cryopreserved. The effects of different concentrations of AST and MLT were assessed by evaluating the motility and motile parameters, functional and structural indicators, antioxidant capacity, and associated indicators of post-thawed sperm. The concentrations of 50 μM AST (AST group), 0.5 mM MLT (MLT group), and 50 μM AST and 0.5 mM MLT (AST.MLT group) were the most effective, as compared to the control (CON group). Furthermore, alterations in the sperm proteomic profile among the three comparisons (AST vs CON, MLT vs CON, AST.MLT vs CON) were determined using an Orbitrap Astral coupled with a data-independent acquisition (DIA) proteomic approach. After comprehensive bioinformatics analysis, significantly differentially abundant proteins (DAPs) among the three comparisons (32 DAPs in AST vs CON, 34 DAPs in MLT vs CON, 116 DAPs in AST.MLT vs CON) and their enriched molecular pathways were discovered, suggesting that AST and MLT may have synergistic effects on frozen sperm by regulating the abundance changes in proteins. In particular, certain positive proteins like ACAT2, PRDX6, G6PD, HSP90a, HSPA8, HSL, ACTN1, and Ezrin, and negative proteins like Cyt , CTSF, and AFU, which are tightly associated with the regulation of sperm motility, oxidative stress, and other metabolic processes, may serve as novel potential biomarkers for evaluating sperm quality after freeze-thawing. In conclusion, this study provides valuable insights into the protective effects of AST and MLT on ram semen quality and replenishes information for further clarifying the molecular mechanism based on the modification of the sperm proteome during cryopreservation. - Source: PubMed
Publication date: 2026/05/08
Li ChunyanZhang YanNi XiaojunZhao XiaoqiLiang JiachongWu GuoquanQuan Guobo - World Health Organization (WHO) in 2010, recommended 0.75 mg/kg single dose primaquine for killing gametocytes after ruling out glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, considering the practical feasibility of G6PD testing, WHO revised the recommendation in 2012 to 0.25 mg/kg single dose primaquine on day-1. This study aims to investigate the efficacy and safety of single-low dose primaquine (0.25 mg/kg) administered on day-1 to intervention arm compared to standard regimen, high-dose primaquine (0.75 mg/kg) administered on day-2 to control arm. - Source: PubMed
Publication date: 2026/05/07
Gulati PayalSinghal RichaGupta ApoorvAnjali Tripathi Praveen KumarKumar DeweshSinha Diamond PrakashSingh S PSingh KhileshwarBaharia Rajendra KumarBhatt K NVasava Ashvin HGamit AmitPatki Manoj BMalla Waseem AKori LokeshSavargaonkar DeepaliChakma NibirParmar DakshAlagesan LeninKashyap RitikaSingh KuldeepAnvikar Anup RBharti Praveen KNitika Nitika - Myocardial ischemia-reperfusion injury (MIRI) is a secondary injury that occurs after treatment for ischemic heart disease. This study aimed to identify key lactylation-related genes (LRGs) in MIRI to enable early diagnosis and reveal potential therapeutic targets for improved patient outcomes. - Source: PubMed
Publication date: 2026/04/21
Bai JieLu YangWei HaidongWang KuiLi WeiZhang Pengbo - Disulfide bond reduction was observed for a monoclonal antibody (mAb1) produced in a Chinese Hamster Ovary (CHO) process, driven primarily by the thioredoxin (Trx)-thioredoxin reductase (TrxR) system present in harvested cell culture fluid (HCCF). To address this issue, we evaluated the Solventum Polisher ST (PST) depth filter as a secondary harvest-stage filtration step designed to remove redox-active enzymes and improve product stability. PST filtration reduced Trx and glucose-6-phosphate 1-dehydrogenase (G6PD) by approximately 1log at loadings up to 150L/m² and non-detectable TrxR at loadings up to 100L/m², as demonstrated by mass spectrometry. Protein biophysical property calculations indicated strong electrostatic attraction between Trx and mAb1 that may facilitate enzyme-antibody co-elution through conventional quaternary amine filters. Compared with dilution, KMnO₄ oxidation, and reversible inhibition using L-cystine, PST filtration most effectively suppressed disulfide bond reduction over seven days at room temperature. Pre-spiking HCCF with guanidinium-containing compounds prior to PST further extended mAb1 stability in the 100-200L/m² fraction from 19.5h to 72.5-95.3h, confirming the functional role of guanidinium groups in mitigating reduction. Scalability up to 50L pilot batch assessments supported consistent performance at larger volumes, demonstrating PST filtration as a practical and robust approach for controlling enzymatic reduction during bioprocess harvest operations. - Source: PubMed
Publication date: 2026/05/04
Wang ZhenshuHartmann MichaelPendyala GeetanjaliGasca VivianHsieh AndrewAlslaiti MajdRivera ShannonKozyryev AntonNandy SumanQian RuilinWu SuyangZhang XiaolinRose PatriciaBennun SandraAhuja Sanjeev