Ask about this productRelated genes to: CYR61 antibody
- Gene:
- CCN1 NIH gene
- Name:
- cellular communication network factor 1
- Previous symbol:
- IGFBP10, CYR61
- Synonyms:
- GIG1
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-02
- Date modifiied:
- 2018-10-11
Related products to: CYR61 antibody
Related articles to: CYR61 antibody
- One of the hallmarks of skin aging is the accumulation of senescent cells, which drives the process of inflammaging. The senescence-associated secretory phenotype (SASP), which characterizes senescent cells, can induce dysfunction in both neighboring skin cells and cells of distant organs. In this study, distant negative effects of senescent dermal fibroblasts on target cells (B-lymphocytes, hepatocytes, and alveolar epithelial cells) were demonstrated. The expression of Klotho, Parkin, SIRT6, VDR, Ki-67, CCN1, p16, and p65 proteins was assessed. The effects of an extract from a plant native to Russia, Hippophae rhamnoides (Sea buckthorn, S), extracts from plants of the African ecosystem Aspalathus linearis (Rooibos, R), Moringa oleifera (Moringa, M), Kigelia Africana (Kigelia, Kg), and an injectable hyaluronic acid gel (HA-gel) on the formation of the senescent phenotype in dermal fibroblasts were evaluated. The studied extracts and HA-gel protected cells from the negative processes induced by genotoxic stress. Moreover, extracts R, S, and HA-gel suppressed the adverse distant effects of damaged fibroblasts, normalizing marker expression in recipient cells, suggesting an influence on signaling pathways involved in the senescent transformation of distant cells. These results suggest considering cosmetic products based on the studied extracts and the injectable preparation as potential agents capable of delaying the aging of not only the skin but also the whole organism, which may be a component of the healthy aging concept. - Source: PubMed
Prokopov A YDrobintseva A OLiubiakina P NKvetnoy I M - Pulmonary arterial hypertension (PAH) is a complex progressive disease associated with high morbidity and mortality. Circulating serum biomarkers have the potential to optimize diagnosis and prognosis in PAH. The cellular communication network (CCN) protein family is a group of similarly structured matricellular proteins with many roles ranging from fibrosis to malignancy. Individual CCN proteins have been associated with PAH in previous studies, but no study has evaluated multiple CCN proteins as potentially relevant biomarkers in PAH. This study sought to establish associations using the circulating concentrations of measurable CCN proteins and PAH diagnosis, severity, outcomes, and other biomarkers. Serum levels of CCN1, CCN2, CCN3, and CCN6 were measured utilizing 225 patients from the PAH Biobank (PAHBiobank) with available hemodynamic data and 40 control samples. Serum levels of CCN1, 2, 3, and 6 proteins were significantly increased in PAH compared to controls. CCN1, CCN2, and CCN3 were associated with a lower 6-min walk distance. CCN2 and CCN3 were also associated with worse New York Heart Association Functional Class. Higher CCN2 and CCN3 levels correlated with higher levels of Endostatin and NT-proBNP. CCN6 was not significantly associated with any hemodynamic or clinical variables in the PAH cohort. Our results suggest that multiple CCN proteins are increased in PAH and that CCN2 and CCN3 have the most potential as novel biomarkers in PAH. - Source: PubMed
Publication date: 2026/05/14
Byrd Carly ESchramm Jennifer EYang JunBarnes Allan EGriffiths MeganNichols William CIvy David DAustin Eric DEverett Allen D - COVID-19 exhibits seasonal epidemics with high risk of mortality in vulnerable population. Identifying accurate parameters for predicting severity and adverse outcomes remains of great clinical significance. - Source: PubMed
Publication date: 2026/05/13
He LihengWei KaiLu JunyaoWei DongMeng XiaoxiaoChen PengZeng LingliJi PingZhang LianZhang XinxinWang RuilanQu JiemingXu JieChen YingyingSu BingYuan LiyunWang Ying - Zhiwang Decoction (ZWD) is a classical traditional Chinese medicine formulation with documented efficacy in alleviating the clinical manifestations of RA, yet its precise molecular mechanisms are not fully defined. - Source: PubMed
Publication date: 2026/05/02
Wang ZihanXie XiangleiLei FeiyangGao JiaxiangZhang QidongLi XinTao QingwenXu Yuan - Cardiac fibrosis is a defining pathological feature of diabetic cardiomyopathy (DCM), and excessive activation of cardiac fibroblasts plays a critical role in regulating cardiomyocyte function through paracrine signaling. CCN1 (cellular communication network factor 1), an extracellular matrix protein involved in intercellular communication, has been suggested to influence cardiac remodeling, although its specific impact on cardiomyocytes in DCM has remained unclear. In this study, we found that CCN1 expression was markedly elevated in cardiac tissues from DCM mouse models and in insulin-resistant cell models, with fibroblasts serving as the primary source. Proteomic analysis and co-culture experiments demonstrated that CCN1 suppressed cardiomyocyte macroautophagy/autophagy. To determine its role in vivo, we generated fibroblast-specific knockout mice and established a DCM model, demonstrating that deletion ameliorated cardiac dysfunction and restored autophagic activity. We further identified ITGAV-ITGB1/integrin αvβ1 as the receptor mediating CCN1 signaling in cardiomyocytes. Molecular dynamics simulations and co-immunoprecipitation experiments confirmed that CCN1 engaged ITGAV-ITGB1/integrin αvβ1 through its cysteine-knot-containing (CT) domain. Mechanistically, this interaction activated the downstream PTK2/FAK-MTOR signaling pathway, leading to inhibition of cardiomyocyte autophagy. Together, these findings reveal a previously unrecognized fibroblast-cardiomyocyte signaling axis in which fibroblast-derived CCN1 drives DCM progression by suppressing autophagy through ITGAV-ITGB1/integrin αvβ1-dependent signaling. This work provides mechanistic insight into the pathogenesis of DCM and identifies CCN1 as a potential therapeutic target for mitigating disease onset and progression.: AAV9: adeno-associated virus serotype 9; ADGRE1/EMR1/F4/80: adhesion G protein-coupled receptor E1; BafA1: bafilomycin A; BSA: bovine serum albumin; C8: compound 8; CCN1: cellular communication network factor 1; CF: cardiac fibroblast; CSA: cross-sectional area; DCM: diabetic cardiomyopathy; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; ELISA: enzyme-linked immunosorbent assay; HE: hematoxylin and eosin; HFD: high-fat diet; HG: high glucose; IR: insulin resistance; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MD: molecular dynamics; MTOR: mechanistic target of rapamycin kinase; NRCM: neonatal rat cardiomyocyte; PDGFRA: platelet derived growth factor receptor alpha; PECAM1/CD31: platelet and endothelial cell adhesion molecule 1; PTK2/FAK: protein tyrosine kinase 2; PTPRC/CD45: protein tyrosine phosphatase receptor type C; RPS6KB1: ribosomal protein S6 kinase B1; S100A4/FSP1: S100 calcium binding protein A4; SQSTM1/p62: sequestosome 1; STZ: streptozotocin; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; WGA: wheat germ agglutinin. - Source: PubMed
Publication date: 2026/05/07
Hu Bo-AngZhang LeiSong MingKong Yan-RuJiao Ya-QiongJia XuZhu PingLi Yu-LinTi YunZhang WeiWang Zhi-HaoZhong Ming