Ask about this productRelated genes to: Vaspin antibody
- Gene:
- SERPINA12 NIH gene
- Name:
- serpin family A member 12
- Previous symbol:
- -
- Synonyms:
- OL-64, Vaspin
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-21
- Date modifiied:
- 2016-04-06
Related products to: Vaspin antibody
Related articles to: Vaspin antibody
- Cardiometabolic diseases are chronic conditions arising from the common pathophysiology of metabolic and cardiovascular disorders accompanied by risk factors such as insulin resistance, obesity, type 2 diabetes, metabolic syndrome, and hypertension. In recent years, the relationship between adipokines such as PAI-1 and vaspin and these diseases has attracted increasing interest. PAI-1 increases cardiovascular risks by inhibiting fibrinolysis, and high PAI-1 levels are associated with obesity and insulin resistance. Vaspin, on the other hand, may have an inhibitory effect on the development of type 2 diabetes and metabolic syndrome by increasing insulin sensitivity. Considering the effects of dietary and lifestyle factors on these molecules, PAI-1 and vaspin are thought to have potential as early biomarkers and therapeutic targets. However, conflicting findings in the literature necessitate further research. Alongside lifestyle interventions based on healthy eating and exercise, changes in PAI-1 and vaspin levels show promise as potential biomarkers for the early diagnosis and prevention of cardiometabolic disorders and the development of personalized treatment strategies. Further research is required to better clarify the molecular mechanisms regulating PAI-1 and vaspin and to determine their potential clinical applications in the prevention and management of cardiometabolic diseases. - Source: PubMed
Publication date: 2026/03/26
Kocabas SuleSanlier Nevin - - Source: PubMed
Publication date: 2026/04/05
Pan LuluBu Zhangyu - The American Heart Association's Life's Essential 8 cardiovascular health (CVH) construct strongly predicts cardiovascular disease (CVD), yet biological processes associated with early-life CVH trajectories are unclear. We examined associations of CVH score and trajectory parameters across childhood with cardiovascular-related proteins. - Source: PubMed
Publication date: 2026/04/03
Lin ZhiRifas-Shiman Sheryl Lde Ferranti Sarah DPerng WeiHivert Marie-FranceAris Izzuddin M - Nagashima-type palmoplantar keratoderma, recently termed as SERPINB7/SERPINA12-palmoplantar epidermal differentiation disorders (pEDD) is the most prevalent palmoplantar keratoderma in East Asia, caused by variants in the SERPINB7 and SERPINA12. Sanger sequencing and next-generation sequencing (NGS) are the gold standard methods for detecting these variants, but their complexity and high cost limit clinical application. This study aimed to develop a rapid, cost-effective, and accurate detection strategy using the amplification refractory variant system-based real-time PCR (ARMS-qPCR) system. Eight key variants were selected: five in SERPINB7 (c.796C>T, c.522dupT, c.650_653delCTGT, c.455G>T, and c.745-553 T>G) and three in SERPINA12 (c.970_971del, c.635-7A>G, c.656A>G). Specific primers for wild-type and mutant sequences were designed based on the ARMS-PCR principle, and reaction conditions were optimized. The ARMS-qPCR strategy was applied to 103 blood samples from SERPINB7/SERPINA12-pEDD patients (n = 53) and healthy controls (n = 50). All samples were validated by Sanger sequencing or NGS, achieving 100% consistency in detecting key variants and an overall accuracy of 93.2% for disease prediction. In conclusion, our ARMS-qPCR strategy provides a rapid, cost-effective, and accurate method for detecting SERPINB7/SERPINA12-pEDD variants, demonstrating significant potential for clinical diagnosis and genetic counseling. - Source: PubMed
Publication date: 2026/03/27
Zhang JingyaLiu YiheLiu JuanMo RanMao XinyuYang YongChen Zhiming - Metabolic syndrome (MetS) is a multifactorial condition characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, all of which increase the risk of cardiovascular disease and type 2 diabetes mellitus. Genetic variants affecting adipokine signaling, such as polymorphisms in the vaspin gene (SERPINA12), have gained attention due to their potential role in modulating metabolic traits. Among these, the single nucleotide polymorphism rs2236242 (T>A) has shown conflicting associations with MetS across populations. This study presents the first comprehensive meta-analysis investigating the association between rs2236242 polymorphism and MetS susceptibility. - Source: PubMed
Publication date: 2026/03/18
Lim Wei-YueAmirul Amira ElinaPung Yuh-FenMohamed RosmawatiNg Rong-XiangZain Shamsul Mohd