Ask about this productRelated genes to: LYVE1 antibody
- Gene:
- LYVE1 NIH gene
- Name:
- lymphatic vessel endothelial hyaluronan receptor 1
- Previous symbol:
- XLKD1
- Synonyms:
- LYVE-1
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2015-07-22
Related products to: LYVE1 antibody
Related articles to: LYVE1 antibody
- This study investigated the mechanism of pirfenidone (PFD) inhibiting metastasis of lung cancer in vivo.A nude mouse lung cancer model was established and treated with PFD (200, 400 μg/mL); lung metastatic tumor weight was recorded, Lyve-1 (lymphatic marker), LC3II (autophagy protein) and polo-like kinase 1 (PLK1) were detected. In human lung lymphatic endothelial cells (HMVEC-LLy) cells, PFD's effects on migration, apoptosis, lymphangiogenesis, and LC3II/LC3I/PLK1 levels were tested. PLK1-overexpressed HMVEC-LLy cells were treated with 400 μg/mL PFD to explore its mechanism. PFD inhibited the weight of lung metastases and down-regulated the expression levels of Lyve-1, LC3II/LC3I and PLK1. In cell experiments, PFD was found to inhibit HMVEC-LLy migration, apoptosis and lymph angiogenesis, as well as down-regulate LC3II/LC3I and PLK1 protein levels, and these effects could be reversed by PLK1 overexpression.PFD may inhibit lung cancer metastasis in vivo by regulating lymph angiogenesis through PLK1 signaling. - Source: PubMed
Publication date: 2026/04/21
Xia ZehaiWang QuanZheng LeiLv Qun - The anatomical localization of lymphatic vessels in bone remains controversial and has led to conflicting interpretations of skeletal lymphatic function. Here we assessed lymphatic identity and localization in bone using mouse genetic labeling, tissue clearance, and three-dimensional imaging. We analyzed long bones after extensive periosteum removal and identified Vegfr3 blood vessels lacking Lyve1 expression within bone marrow, whereas Vegfr3 Lyve1 lymphatic vessels were confined to residual periosteal regions. Genetic lineage tracing using Prox1-Cre/ER;mScarlet further confirmed that lymphatic vessels are absent from long bone marrow and restricted to periosteal compartments, particularly in fibrous but not cambial layers. Extending these analyses to the mandible, we observed Vegfr3 Lyve1 lymphatic vessels localized to periarticular soft tissues surrounding the temporomandibular joint (TMJ), while mandibular bone marrow contained only Vegfr3 Lyve1 blood vessels and lacked Prox1 lineage-traced lymphatic vessels. Together, these findings establish that lymphatic vessels in bone are confined to periosteal and periarticular compartments and absent from bone marrow, providing a framework for interpreting lymphatic contributions to skeletal physiology and disease. - Source: PubMed
Publication date: 2026/04/08
Chang QingShu YangLiu HongzhiKo Pao-FenChen Jian-Fu - Recent studies in mouse models have demonstrated that macrophages in adult tissues are maintained not only by the differentiation of bone marrow-derived monocytes but also by the proliferation of macrophages originating from the yolk sac or fetal liver. However, the extent to which this paradigm shift occurs in human tissues is not fully understood. In this study, we detected a human peritoneal macrophage subset that exhibited embryonic origin-like phenotypes. Macrophages in the ascites of patients with gastric cancer were divided into CCR2 and CCR2 subsets, the ratios of which varied among donors. The gene expression profiles of these subsets were similar to those of the macrophage subsets in the heart. CRIg was recently reported as a marker for distinguishing between two macrophage subsets in the ascites of patients with cirrhosis. CCR2 and CCR2 subsets expressed high and low levels of CRIg, respectively. Importantly, the CCR2CRIg subset expressed the cell proliferation marker Ki67 and the recently proposed core markers (TIMD4, LYVE1, and FOLR2) of embryo-derived macrophages at higher levels than the CCR2CRIg subset. Moreover, many other markers shared by TIMD4LYVE1FOLR2 macrophages in heart, lung, kidney, and liver exhibited similar expression patterns in the peritoneal CCR2CRIg subset. These results suggest that the CCR2CRIg subset in the peritoneal cavity contains macrophages with embryonic origin. - Source: PubMed
Publication date: 2026/04/16
Takahashi NaofumiHabash Sara AKomohara YoshihiroUsuki ShingoYasunaga Kei-IchiroHino ShinjiroAbdelnaser Randa AEinarsdottir ThorbjorgNomura TakushiYonemura AtsukoIshimoto TakatsuguSuzu Shinya - Pulmonary lymphatics play multiple essential roles in lung homeostasis through interstitial fluid removal, traffic of immune cells, and antigen presentation. This highly branching vascular bed comprises initial capillaries, pre-collecting vessels, and collecting lymphatics, and it is lined by characteristic lymphatic endothelial cells (LECs). These cells are distinct from blood endothelial cells in their structure, molecular markers (e.g., PROX1, LYVE-1, VEGFR-3), and responsiveness to inflammatory and mechanical stimuli. In health, LECs preserve barrier integrity, promote immune surveillance, and support unidirectional lymph flow. However, during pulmonary inflammation or injury, LECs may undergo phenotypic changes that impair function and promote local coagulation. This review consolidates current knowledge on pulmonary lymphatic vessel structure, function, and LEC biology, with a focus on their involvement in inflammation and coagulation pathways. We examine how cigarette smoke disrupts LEC homeostasis, leading to endothelial injury, pro-coagulant factor upregulation (e.g., tissue factor, PAI-1), and fibrin-rich thrombosis in lung lymphatics. While vaping induces oxidative stress and vascular inflammation, its effects on the pulmonary lymphatic system have not been clearly explained. Based on shared pathological features with smoking, we propose potential mechanisms by which e-cigarette aerosols may contribute to lymphatic endothelial dysfunction and altered coagulation in lungs. Given the increasing prevalence of vaping, further research using , , and human studies is needed to elucidate how inhaled toxicants alter LEC function and to identify novel targets for preserving lymphatic health in lung disease. - Source: PubMed
Publication date: 2026/04/16
Raimi HodaHong JiwonMaldonado Zimbron VictorPhillips AnthonyBurrowes Kelly - A 22-y-old, intact male African green monkey () with a pedunculated cutaneous ulcerated spheroid mass on the left flank was autopsied. Histologically, the mass was infiltrative, with neoplastic cells forming empty vascular channels lined by a monolayer of polygonal neoplastic cells, many with eosinophilic intracytoplasmic granules, supported by abundant fibrous stroma. Immunohistochemically, neoplastic cells had strong immunolabeling with vimentin, moderate immunolabeling with LYVE1 and PROX1 antibodies, and no cytokeratin or CD31 immunolabeling. Ultrastructurally, a basal lamina was absent, nuclei had a 1:4 heterochromatin:euchromatin ratio, with a mild-to-moderate increase in thickness and asymmetrically distributed nuclear fibrous lamina, enlarged compacted nucleolus, round mitochondria, conspicuous rough endoplasmic reticulum, and membrane-bound electron-dense granules. Intercellular desmosomes were present in clusters of neoplastic cells. Lymphangiosarcoma has not been previously reported in non-human primates, to our knowledge. Our case highlights the importance of integrating histopathology, immunohistochemistry, and ultrastructural analysis to accurately diagnose rare vascular tumors, such as lymphangiosarcoma. - Source: PubMed
Publication date: 2026/04/06
Bochynska DianaArmien AnibalHarris MacallisterCurtis AndrewBolfa Pompei