Ask about this productRelated genes to: SHBG protein
- Gene:
- SHBG NIH gene
- Name:
- sex hormone binding globulin
- Previous symbol:
- -
- Synonyms:
- ABP, TEBG, MGC126834, MGC138391
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2016-04-04
Related products to: SHBG protein
Related articles to: SHBG protein
- The oxidative balance score (OBS) was developed to reflect the overall exposure of the body to antioxidants and pro-oxidants in the individual's lifestyle and diet. The research aims to explore the relationship between OBS and sex hormones, including total testosterone (TT) and estradiol (E2), as well as indices including sex hormone-binding globulin (SHBG), testosterone deficiency (TD), free testosterone, and the ratio of TT to E2. - Source: PubMed
Publication date: 2026/05/18
Tao KaiZhang WeiHuang WeichaoLu GuofaXu HangQiu ShiYang Lu - The dynamic interplay between body fat distribution and sex hormone metabolism has been drawing escalating interest, especially in light of the frequently observed fluctuations in these indicators among male obese patients. Furthermore, exploring this connection holds paramount importance for the effective treatment and prevention of male obesity-related diseases. This study examines the relationships between regional fat depots (visceral, subcutaneous, epicardial volumes) and tissue-specific fat content (liver, pancreas, vertebra, muscle) with circulating testosterone and sex hormone‑binding globulin (SHBG) levels in men. - Source: PubMed
Publication date: 2026/04/08
Huang MengyueLi WantingWu MengchenZhu ZhengheHan LiminZhang YongZhang HaohaoLiu Jingjing - Low plasma sex hormone-binding globulin (SHBG) levels are commonly observed in metabolic dysfunction-associated fatty liver disease (MASLD), a spectrum of disorders ranging from simple hepatocellular steatosis to steatohepatitis, fibrosis, and irreversible cirrhosis. We have previously demonstrated that SHBG overexpression reduces hepatic lipid accumulation by inhibiting lipogenesis both in vitro and in vivo. - Source: PubMed
Publication date: 2026/05/16
Alvarez-Guaita AnnaCabrera-Serra JuliaPerez-Gonzalez BeatrizSalcedo-Allende Maria TeresaFuertes-Rioja LidiaRamos-Perez LorenaHernandez CristinaSimó RafaelSelva David M - The extensive application of bisphenol A (BPA), an endocrine-disrupting substance in polymer-based products and consumer commodities, has sparked concerns over its carcinogenic potential. However, the molecular mechanisms underlying BPA-induced gastric carcinogenesis remain poorly understood. We used network toxicology and molecular docking analysis to uncover the pivotal targets and mechanisms underlying BPA-associated gastric carcinogenesis. Potential BPA-related targets and differentially expressed genes in gastric cancer (GC) were collected from publicly available databases to identify hub genes. A prognostic risk assessment model utilizing hub genes, with molecular docking simulations, was performed to confirm the binding interactions between BPA and target proteins. A total of 27 potential targets associated with both BPA exposure and GC were identified. The protein-protein interaction network analysis revealed 19 hub genes, with core targets including MMP9, ADRB2, PTGS1, SLC6A4, ERBB2, MAPT, AR, SLC6A3, CNR1, PDE5A, DRD2, KCNH2, MC4R, CALCR, CHRM1, ADRB3, CXCR2, MMP1, and SHBG. Enrichment analysis demonstrated these hub genes were significantly involved in neuroactive ligand-receptor interaction, calcium signaling pathway, cGMP-PKG signaling pathway, and chemical carcinogenesis-receptor activation pathways. Prognostic analysis identified six hub genes (CALCR, ADRB3, CNR1, HRH2, KCNH2, and AR) significantly associated with patient survival. Molecular docking simulations demonstrated robust interaction affinities of BPA with the identified core target proteins. This study reveals that BPA may influence GC development and progression through multiple targets and signaling pathways, particularly involving G protein-coupled receptor signaling, hormone regulation, and neurological pathways. - Source: PubMed
Publication date: 2026/05/14
Yu Wen-YanZhang Yue - Most studies on the impact of vitamin D on sex hormones focus on specific populations, such as older males, Asian males, or those with certain health conditions. Limited evidence exists on the relationship between vitamin D and sex hormones in American women. This cross-sectional analysis used National Health and Nutrition Examination Survey (NHANES) data to explore the association between serum vitamin D levels and sex hormones levels in women. Data from NHANES (2021-2023) were analyzed. Participants were categorized by serum vitamin D levels: Deficient (<50 nmol/L), Insufficient (50-74.99 nmol/L), and Adequate ( ≥ 75 nmol/L). One-way ANOVA and Chi-square tests were used for comparisons, and linear regression evaluated associations. Our analysis specifically focused on a subset of 3181 women aged 18 years and older (18-80 years). Women in the adequate vitamin D group had lower body mass index (BMI) (29.16 vs. 32.10 kg/m², p < 0.001), lower total testosterone (24.10 vs. 32.28 ng/dL, p < 0.001), progesterone (139.05 vs. 229.73 ng/dL, p < 0.001), estrone sulfate (687.10 vs. 1023.08 pg/mL, p < 0.001), and dehydroepiandrosterone sulfate (DHEAS) (66.41 vs. 100.56 µg/dL, p < 0.001) compared to the deficient vitamin D group. They also had higher sex hormone-binding globulin (SHBG) (70.37 vs. 58.55 nmol/L, p < 0.001), follicle-stimulating hormone (FSH) (50.30 vs. 23.99 mIU/mL, p < 0.001), and luteinizing hormone (LH) (26.39 vs. 16.64 mIU/mL, p < 0.001) compared to the deficient vitamin D group. Linear regression revealed that higher serum vitamin D was inversely associated with 17α-hydroxyprogesterone (Beta = -0.85, P = 0.023), androstenedione (Beta = -0.181, p < 0.001), anti-Müllerian hormone (Beta = -0.238, p < 0.001), DHEAS (Beta = -0.204, p < 0.001), total testosterone (Beta = -0.080, P = 0.042), while showing a positive association with follicle-stimulating hormone (Beta = 0.260, p < 0.001) and luteinizing hormone (Beta = 0.208, p < 0.001). Serum vitamin D levels were negatively associated with testosterone and estradiol in American women, particularly in older individuals. - Source: PubMed
Publication date: 2026/05/13
He YunanLi JinhongQiu JiahuiShi Qingquan